The Clearance Of Soluble And Particulate Aerosols Deposited In The Human Lung
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Author | : Sponsored by The Health Effects Institute |
Publisher | : National Academies Press |
Total Pages | : 703 |
Release | : 1988-01-01 |
Genre | : Science |
ISBN | : 0309037263 |
"The combination of scientific and institutional integrity represented by this book is unusual. It should be a model for future endeavors to help quantify environmental risk as a basis for good decisionmaking." â€"William D. Ruckelshaus, from the foreword. This volume, prepared under the auspices of the Health Effects Institute, an independent research organization created and funded jointly by the Environmental Protection Agency and the automobile industry, brings together experts on atmospheric exposure and on the biological effects of toxic substances to examine what is knownâ€"and not knownâ€"about the human health risks of automotive emissions.
Author | : National Research Council (U.S.). Subcommittee on Airborne Particles |
Publisher | : |
Total Pages | : 376 |
Release | : 1979 |
Genre | : Science |
ISBN | : |
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 351 |
Release | : 1986-02-01 |
Genre | : Medical |
ISBN | : 0309074568 |
This comprehensive book examines the recent research investigating the characteristics and composition of different types of environmental tobacco smoke (ETS) and discusses possible health effects of ETS. The volume presents an overview of methods used to determine exposures to environmental smoke and reviews both chronic and acute health effects. Many recommendations are made for areas of further research, including the differences between smokers and nonsmokers in absorbing, metabolizing, and excreting the components of ETS, and the possible effects of ETS exposure during childhood and fetal life.
Author | : Chantal J Darquenne |
Publisher | : World Scientific |
Total Pages | : 222 |
Release | : 2020-03-10 |
Genre | : Medical |
ISBN | : 9811212198 |
This book provides a comprehensive overview of the field of aerosol science related to particle inhalation and its effect on the lung, predominately in humans. It covers the basics of aerosol behavior, transport, deposition, clearance, and effects of aerosols, both environmental and therapeutic. Aimed at the researcher entering the field of aerosol inhalation it provides a valuable introductory resource in an accessible format.
Author | : United States. Public Health Service. Office of the Surgeon General |
Publisher | : |
Total Pages | : 728 |
Release | : 2010 |
Genre | : Government publications |
ISBN | : |
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 204 |
Release | : 1989-02-01 |
Genre | : Science |
ISBN | : 9780309039901 |
Biologic markersâ€"indicators of biological exposure or changeâ€"offer the promise of early detection of disease caused by environmental exposure. Researchers have used these markers to discover indications of pulmonary damage from low-level ozone, a finding with serious implications for health professionals and environmental regulators. Biologic Markers in Pulmonary Toxicology is a comprehensive study of this use of biologic markers. Focusing on the respiratory tract as an entryway for airborne pollutants, this volume reviews new ways of measuring markers, the need for markers to indicate dose or exposure levels, noninvasive respiratory function tests for use with healthy humans to detect sensitivity to inhaled pollutants, approaches to evaluating markers down to the cellular and biochemical levels, and more.
Author | : Ali Nokhodchi |
Publisher | : John Wiley & Sons |
Total Pages | : 392 |
Release | : 2015-08-03 |
Genre | : Science |
ISBN | : 1118799542 |
Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation design, including the interaction between the active pharmaceutical ingredient(s) (APIs), excipients and devices. This book seeks to cover some of the most pertinent issues and challenges of such formulation design associated with industrial production and desirable clinical outcome. The chapter topics have been selected with a view to integrating the factors that require consideration in the selection and design of device and formulation components which impact upon patient usability and clinical effectiveness. The challenges involved with the delivery of macromolecules by inhalation to both adult and pediatric patients are also covered. Written by leading international experts from both academia and industry, the book will help readers (formulation design scientists, researchers and post-graduate and specialized undergraduate students) develop a deep understanding of key aspects of inhalation formulations as well as detail ongoing challenges and advances associated with their development.
Author | : Lidia Morawska |
Publisher | : John Wiley & Sons |
Total Pages | : 467 |
Release | : 2006-12-13 |
Genre | : Science |
ISBN | : 3527609202 |
Covering the fundamentals of air-borne particles and settled dust in the indoor environment, this handy reference investigates: * relevant definitions and terminology, * characteristics, * sources, * sampling techniques and instrumentation, * exposure assessment, * monitoring methods. The result is a useful and comprehensive overview for chemists, physicists and biologists, postgraduate students, medical practitioners, occupational health professionals, building owners and managers, building, construction and air-conditioning engineers, architects, environmental lawyers, government and regulatory professionals.
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 623 |
Release | : 1988-02-01 |
Genre | : Science |
ISBN | : 0309037891 |
This book describes hazards from radon progeny and other alpha-emitters that humans may inhale or ingest from their environment. In their analysis, the authors summarize in one document clinical and epidemiological evidence, the results of animal studies, research on alpha-particle damage at the cellular level, metabolic pathways for internal alpha-emitters, dosimetry and microdosimetry of radionuclides deposited in specific tissues, and the chemical toxicity of some low-specific-activity alpha-emitters. Techniques for estimating the risks to humans posed by radon and other internally deposited alpha-emitters are offered, along with a discussion of formulas, models, methods, and the level of uncertainty inherent in the risk estimates.
Author | : Bryan Corrin |
Publisher | : Elsevier Health Sciences |
Total Pages | : 785 |
Release | : 2011-02-25 |
Genre | : Medical |
ISBN | : 0702046221 |
With an emphasis on practical diagnostic problem solving, Pathology of the Lungs, 3rd Edition provides the pulmonary pathologist and the general surgical pathologist with an accessible, comprehensive guide to the recognition and interpretation of common and rare neoplastic and non-neoplastic lung conditions. The text is written by two authors and covers all topics in a consistent manner without the redundancies or lapses that are common in multi-authored texts. The text is lavishly illustrated with the highest quality illustrations which accurately depict the histologic, immunohistochemical and cytologic findings under consideration and it is supplemented throughout with practical tips and advice from two internationally respected experts. The user-friendly design and format allows rapid access to essential information and the incorporation throughout of relevant clinical and radiographic information makes it a complete diagnostic resource inside the reporting room. Approximately 1,000 high quality full color illustrations.Provides the user with a complete visual guide to each specimen and assists in the recognition and diagnosis of any slide looked at under the microscope. Comprehensive coverage of both common and rare lung diseases and disorders. One stop consultation resource for the reporting room or study, no need to go further to get questions answered. Clinical background and ancillary radiographs incorporated throughout.Provides the user with all of the necessary diagnostic tools to make a complete and accurate pathologic report. Practical advice and tips from two of the world’s recognized experts. Provides the trainee and general surgical pathologist with time saving diagnostic clues when dealing with difficult specimens. Consistent and uniform approach incorporated for each disease and disorder (Etiology, pathogenesis, clinical features, pathologic features, differential diagnosis) User-friendly format enables quick and easy navigation to the key information required. Extensive use of summary tables, charts and graphs throughout the text. Helps simplify and clarify complex concepts and facilitates “at a glance comparisons between entities. Extensive reference list highlights landmark articles as well as including most up-to-date citations. Directs the trainee and practitioner to the most recent and authoritative sources for further reading and investigation