The Circadian Clock
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| Author | : Paolo Sassone-Corsi |
| Publisher | : Springer |
| Total Pages | : 141 |
| Release | : 2016-04-04 |
| Genre | : Medical |
| ISBN | : 3319270699 |
Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.
| Author | : Satchin Panda, PhD |
| Publisher | : Rodale Books |
| Total Pages | : 290 |
| Release | : 2018-06-12 |
| Genre | : Health & Fitness |
| ISBN | : 1635652448 |
When we eat may be as important as what we eat. Like most people, you probably wake up, get hungry for meals and doze off in bed around the same time every day. If you’ve ever experienced jet lag or pulled an all-nighter, you know that this schedule can easily be thrown off kilter. But for some people, that imbalance—difficulty sleeping at night, hunger at odd times, or sudden fatigue at noon—is a constant. If you're one of those people, Dr. Satchin Panda, one of the leading researchers on circadian rhythms, has a plan to reset your body clock. Beginning with an in-depth explanation of the circadian clock—why it’s important, how it works, and how to know it isn’t working—The Circadian Code outlines lifestyle changes to make to get back on track. It's a concrete plan to enhance weight loss, improve sleep, optimize exercise, and manage technology so that it doesn’t interfere with your body’s natural rhythm. Dr. Panda’s life-changing methods show you how to prevent and reverse ailments like diabetes, cancer, and dementia, as well as microbiome conditions like acid reflux, heartburn, and irritable bowel disease.
| Author | : Leon Kreitzman |
| Publisher | : Profile Books |
| Total Pages | : 288 |
| Release | : 2011-09-30 |
| Genre | : Science |
| ISBN | : 1847653723 |
Popular science at its most exciting: the breaking new world of chronobiology - understanding the rhythm of life in humans and all plants and animals. The entire natural world is full of rhythms. The early bird catches the worm -and migrates to an internal calendar. Dormice hibernate away the winter. Plants open and close their flowers at the same hour each day. Bees search out nectar-rich flowers day after day. There are cicadas that can breed for only two weeks every 17 years. And in humans: why are people who work anti-social shifts more illness prone and die younger? What is jet-lag and can anything help? Why do teenagers refuse to get up in the morning, and are the rest of us really 'larks' or 'owls'? Why are most people born (and die) between 3am-5am? And should patients be given medicines (and operations) at set times of day, because the body reacts so differently in the morning, evening and at night? The answers lie in our biological clocks the mechanisms which give order to all living things. They impose a structure that enables us to change our behaviour in relation to the time of day, month or year. They are reset at sunrise and sunset each day to link astronomical time with an organism's internal time.
| Author | : Michelle L. Gumz |
| Publisher | : Springer |
| Total Pages | : 382 |
| Release | : 2016-02-29 |
| Genre | : Medical |
| ISBN | : 1493934503 |
This book sheds new light on the molecular mechanisms that generate circadian rhythms. It examines how biological rhythms influence physiological processes such as sleep, hormone synthesis and secretion, immunity, kidney function, the cardiovascular system, blood pressure, and the digestive system. Clinical implications are considered while exploring the impact of rhythms on neuropsychiatric disorders and chronotherapy’s potential for reducing cardiovascular risk. Offering a cross-section of expertise in both basic and translational (bench-to-bedside) research, this book serves as a guide for physicians and scientists who wish to learn more about the impact of circadian rhythms on physiological processes in health and disease.
| Author | : Carl Hirschie Johnson |
| Publisher | : Springer Nature |
| Total Pages | : 424 |
| Release | : 2021-06-21 |
| Genre | : Science |
| ISBN | : 3030721582 |
This book addresses multiple aspects of biological clocks in prokaryotes. The first part of the book deals with the circadian clock system in cyanobacteria, i.e. the pioneer of bacterial clocks. Starting with the history and background of cyanobacteria and circadian rhythms in microorganisms, the topics range from the molecular basis, structure and evolution of the circadian clock to modelling approaches, Kai systems in cyanobacteria and biotechnological applications. In the second part, emergent timekeeping properties of bacteria in microbiomes and bacteria other than cyanobacteria are discussed. Since the discovery of circadian rhythms in cyanobacteria in the late 1980s, the field has exploded with new information. The cyanobacterial model system for studying circadian rhythms (Synechococcus elongatus), has allowed a detailed genetic dissection of the bacterial clock due to state-of-the-art methods in molecular, structural, and evolutionary biology. Cutting-edge research spanning from cyanobacteria and circadian phenomena in other kinds of bacteria, to microbiomes has now given the field another major boost. This book is aimed at junior and senior researchers alike. Students or researchers new to the field of biological clocks in prokaryotes will get a comprehensive overview, while more experienced researchers will get an update on the latest developments.
| Author | : Urs Albrecht |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 306 |
| Release | : 2010-01-23 |
| Genre | : Science |
| ISBN | : 1441912622 |
With the invitation to edit this volume, I wanted to take the opportunity to assemble reviews on different aspects of circadian clocks and rhythms. Although most c- tributions in this volume focus on mammalian circadian clocks, the historical int- duction and comparative clocks section illustrate the importance of various other organisms in deciphering the mechanisms and principles of circadian biology. Circadian rhythms have been studied for centuries, but only recently, a mole- lar understanding of this process has emerged. This has taken research on circadian clocks from mystic phenomenology to a mechanistic level; chains of molecular events can describe phenomena with remarkable accuracy. Nevertheless, current models of the functioning of circadian clocks are still rudimentary. This is not due to the faultiness of discovered mechanisms, but due to the lack of undiscovered processes involved in contributing to circadian rhythmicity. We know for example, that the general circadian mechanism is not regulated equally in all tissues of m- mals. Hence, a lot still needs to be discovered to get a full understanding of cir- dian rhythms at the systems level. In this respect, technology has advanced at high speed in the last years and provided us with data illustrating the sheer complexity of regulation of physiological processes in organisms. To handle this information, computer aided integration of the results is of utmost importance in order to d- cover novel concepts that ultimately need to be tested experimentally.
| Author | : Olivia Engmann |
| Publisher | : Springer Nature |
| Total Pages | : 193 |
| Release | : 2021-11-13 |
| Genre | : Medical |
| ISBN | : 3030811476 |
In this book, leading experts in the field review how circadian rhythms impact the brain. An essential function of mammalian life is the exploitation of the regularities provided by the 24-hour cycle of day and night. The development and evolution of circadian clock mechanisms have allowed us to optimally adapt our behavior and physiology to the external world. Not surprisingly, a growing body of evidence links the disruption of circadian rhythms by genetic, lifestyle and environmental factors to illnesses of the brain. In the first section of the book, readers will learn about the molecular and anatomic architecture of circadian function in mammals. The ways in which environmental disruptions and misalignments can influence such mechanisms and therefore impair brain function and health status are also addressed. In the second part, the focus shifts to those brain regions responsible for brain function and the body-wide regulation of circadian function. Amongst others, special attention is paid to the role of astrocytes and the brain’s reward and hyprocretin / orexin systems. The book concludes with an extensive discussion on the consequences of circadian rhythm dysfunction. Several chapters present the latest findings on Attention Deficit Hyperactivity Disorder, schizophrenia, autism spectrum disorder, drug abuse and mood disorders. Written by auhorities in the field, the book provides a state-of-the-art review of the latest findings on circadian clocks in the brain and highlights their potentially far-reaching impacts on our health and well-being. As such, it is essential reading for all neuroscientists and clinicians seeking to understand the intricate connections between circadian rhythms and brain health and illness.
| Author | : Charles A. Czeisler |
| Publisher | : |
| Total Pages | : 692 |
| Release | : 1978 |
| Genre | : Human physiology |
| ISBN | : |
| Author | : Daniel B. Forger |
| Publisher | : MIT Press |
| Total Pages | : 369 |
| Release | : 2024-08-06 |
| Genre | : Science |
| ISBN | : 0262552817 |
An introduction to the mathematical, computational, and analytical techniques used for modeling biological rhythms, presenting tools from many disciplines and example applications. All areas of biology and medicine contain rhythms, and these behaviors are best understood through mathematical tools and techniques. This book offers a survey of mathematical, computational, and analytical techniques used for modeling biological rhythms, gathering these methods for the first time in one volume. Drawing on material from such disciplines as mathematical biology, nonlinear dynamics, physics, statistics, and engineering, it presents practical advice and techniques for studying biological rhythms, with a common language. The chapters proceed with increasing mathematical abstraction. Part I, on models, highlights the implicit assumptions and common pitfalls of modeling, and is accessible to readers with basic knowledge of differential equations and linear algebra. Part II, on behaviors, focuses on simpler models, describing common properties of biological rhythms that range from the firing properties of squid giant axon to human circadian rhythms. Part III, on mathematical techniques, guides readers who have specific models or goals in mind. Sections on “frontiers” present the latest research; “theory” sections present interesting mathematical results using more accessible approaches than can be found elsewhere. Each chapter offers exercises. Commented MATLAB code is provided to help readers get practical experience. The book, by an expert in the field, can be used as a textbook for undergraduate courses in mathematical biology or graduate courses in modeling biological rhythms and as a reference for researchers.
| Author | : Kasia Kozlowska |
| Publisher | : Springer Nature |
| Total Pages | : 397 |
| Release | : 2020-09-30 |
| Genre | : Psychology |
| ISBN | : 303046184X |
This open access book sets out the stress-system model for functional somatic symptoms in children and adolescents. The book begins by exploring the initial encounter between the paediatrician, child, and family, moves through the assessment process, including the formulation and the treatment contract, and then describes the various forms of treatment that are designed to settle the child’s dysregulated stress system. This approach both provides a new understanding of how such symptoms emerge – typically, through a history of recurrent or chronic stress, either physical or psychological – and points the way to effective assessment, management, and treatment that put the child (and family) back on the road to health and well-being.
