The Biosynthesis Of Biotin In Microorganisms Ii Mechanism Of The Regulation Of Biotin Synthesis In Escherichia Coli
Download The Biosynthesis Of Biotin In Microorganisms Ii Mechanism Of The Regulation Of Biotin Synthesis In Escherichia Coli full books in PDF, epub, and Kindle. Read online free The Biosynthesis Of Biotin In Microorganisms Ii Mechanism Of The Regulation Of Biotin Synthesis In Escherichia Coli ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author | : Chik H. Pai |
Publisher | : |
Total Pages | : 7 |
Release | : 1964 |
Genre | : |
ISBN | : |
The mechanism of the physiological control of biotin synthesis in Escherichia coli by exogenous biotin has been studied under conditions where enzyme synthesis was inhibited by chloramphenicol or ultraviolet irradiation. The results of such studies suggest that the regulation of biotin synthesis occurs via repression rather than feedback. The experimental findings are discussed in relation to the control of vitamin and amino acid biosynthesis. (Author).
Author | : Chik H. Pai |
Publisher | : |
Total Pages | : 8 |
Release | : 1964 |
Genre | : |
ISBN | : |
The time course of biotin synthesis and the distribution of the vitamin were studied in Escherichia coli growing in biotin-free and biotin-supplemented media. In biotin-free media, biotin synthesis occurred at a maximum rate just prior to the onset of the logarithmic phase of growth with continuous excretion of the vitamin into the growth medium. The bound biotin levels of the cells varied depending on cultural conditions, but the content of intracellular free biotin was always the highest at an early incubation time. At the end of the logarithmic phase the majority of 'total' biotin synthesized was found extracellularly. However, the extent of overproduction of 'true' biotin, particularly in an enriched medium, was very small. In biotin-supplemented media, the time course of synthesis was completely different and the total amount of biotin synthesized varied inversely with the concentration of (+)-biotin present prior to the inoculation of bacteria . The inhibition of biotin synthesis was achieved only by (+)-biotin; other biotin vitamers had no effect. The results suggest that biotin synthesis is controlled by (+)-biotin. (Author).
Author | : Chik H. Pai |
Publisher | : |
Total Pages | : 7 |
Release | : 1964 |
Genre | : |
ISBN | : |
The conversion of desthiobiotin to (+)-biotin by Escherichia coli has been studied. Desthiobiotin is converted to (+)-biotin, as identified by bioautography by both growing and resting cells of a biotinless mutant strain of E. coli. The conversion is also demonstrable in resting cells of a wild-type strain of E. coli. No converting activity was found in either the mutant or wild-type strains which had been grown in the presence of exogenous (+)-biotin. Oxybiotin and desthiobiotin did not cause such repression. The results are in agreement with previous findings that biotin synthesis from glucose is repressed by (+)-biotin, and supports the role of this converting step as the functioning biosynthetic route to the vitamin. (Author).
Author | : F. L. Billings |
Publisher | : Vaudreuil, Que. : Hoffmann-La Roche |
Total Pages | : 318 |
Release | : 1975 |
Genre | : Biotin |
ISBN | : |
Author | : Volker F. Wendisch |
Publisher | : Springer Science & Business Media |
Total Pages | : 418 |
Release | : 2007-03-24 |
Genre | : Science |
ISBN | : 3540485961 |
This book presents the current knowledge of fundamental as well as applied microbiology of amino acids. Coverage details the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The book also examines the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and as food and feed additives.
Author | : |
Publisher | : |
Total Pages | : 780 |
Release | : |
Genre | : Science |
ISBN | : |
Author | : Erick J. Vandamme |
Publisher | : Springer Science & Business Media |
Total Pages | : 440 |
Release | : 2012-12-06 |
Genre | : Science |
ISBN | : 9400911114 |
Vitamins and related growth factors belong to the few chemicals with a positive appeal to most people; the name evokes health, vitality, fitness, strength . . . . each one of us indeed needs his daily intake of vitamins, which should normally be provided via a balanced and varied diet. However, current food habits or preferences, or food processing and preservation methods do not always assure a sufficient natural daily vitamin supply, even for a healthy human being; this is all the more true for stressed or sick individuals. Although modern society is seldom confronted with the notorious avitaminoses of the past, they do still occur frequently in overpopulated and poverty- and famine-struck regions in many parts of the world. Apart from their in-vivo nutritional-physiological roles as growth factors for man, animals, plants and micro-organisms, vitamin compounds are now being introduced increasingly as food/feed additives, as medical-therapeutical agents, as health-aids, and also as technical aids. Indeed, today an impressive number of processed foods, feeds, cosmetics, pharmaceuticals and chemicals contain extra added vitamins or vitamin-related compounds, and single or multivitamin preparations are commonly taken or prescribed. These reflections do indicate that there is an extra need for vitamin supply, other than that provided from plant and animal food resources. Most added vitamins are indeed now prepared chemically and/or biotechnologically via fermentation/bioconversion processes. Similarly, other related growth factors, provitamins, vitamin-like com pounds, i. e.
Author | : Katharine Leigh Armstrong |
Publisher | : |
Total Pages | : 152 |
Release | : 1949 |
Genre | : |
ISBN | : |
Author | : |
Publisher | : |
Total Pages | : 1066 |
Release | : 1973 |
Genre | : Bacteriology |
ISBN | : |
Author | : L Ornston |
Publisher | : Elsevier |
Total Pages | : 403 |
Release | : 2012-12-02 |
Genre | : Science |
ISBN | : 0323152031 |
Experiences in Biochemical Perception discusses the breadth of contributions of I. C. Gunsalus, a versatile biochemist, in the field of biochemistry. This book explores the mechanism of electron transport to protein structure and documents the interface between the Gunsalus laboratory and the physicists. Organized into five parts encompassing 27 chapters, this book starts with a description of metabolic processes and the study of pyruvate oxidation. This text then illustrates how studies of microbial respiration led to the discovery of pyridoxl phosphate. Other chapters review dehydrogenases that participate in the dissimilation of branch-chain aromatic acids. This book further discusses the phosphorus–nitrogen bond in phosphorylated proteins and the inactivation of glutamine synthetase. The final chapter describes the elucidation of the function of the coenzyme biotin and generalizes about the use of bacteria in nutritional studies. This book is a valuable resource for readers and researchers engaged in the study of genetics, enzymology, microbiology, chemistry, and spectroscopy.