The Biology Of Heat Shock Proteins And Molecular Chaperones
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Regulation of Heat Shock Protein Responses
Author | : Alexzander A A Asea |
Publisher | : Springer |
Total Pages | : 471 |
Release | : 2018-05-01 |
Genre | : Medical |
ISBN | : 3319747150 |
This books provides the most up-to-date reviews on current advances in our understanding of the regulation of heat shock protein responses. Key basic scientists and clinical research laboratories from major universities, academic medical centers and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into four sections, including, Section I - HSP and Stress Responses; Section II - Chaperone Functions of HSP; Section III - HSP in Human Diseases; Section IV - Prognosis & Diagnosis of HSP. The book is a must read for researchers involved in biomedical research, drug discovery and design to improve human health.
Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks
Author | : Peter Csermely |
Publisher | : Springer Science & Business Media |
Total Pages | : 218 |
Release | : 2007-08-09 |
Genre | : Science |
ISBN | : 0387399755 |
This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.
Heat Shock Proteins and Stress
Author | : Alexzander A. A. Asea |
Publisher | : Springer |
Total Pages | : 317 |
Release | : 2018-10-24 |
Genre | : Science |
ISBN | : 3319907255 |
The book Heat Shock Proteins and Stress provides the most comprehensive review on contemporary knowledge on the role of HSP in Stress. Using an integrative approach to understanding the regulation of HSP responses, the contributors provide a synopsis of novel mechanisms by which HSP responses are regulated under normal physiological and pathophysiological conditions. Key basic and clinical research laboratories from major universities and academic medical hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychologists, Human Physiology, Zoologists, Botanists, Biotechnology, Molecular Medicine, Infectious Diseases Experts and Pathologists.
Guidebook to Molecular Chaperones and Protein-Folding Catalysts
Author | : Mary-Jane Gething |
Publisher | : OUP Oxford |
Total Pages | : 586 |
Release | : 1997-11-27 |
Genre | : Medical |
ISBN | : 0191547271 |
The precise shape of a protein is a crucial factor in its function. How do proteins become folded into the right conformation? Molecular chaperones and protein folding catalysts bind to developing polypeptides in the cytoplasm and ensure correct folding and transport. This Guidebook catalogues the latest information on nearly 200 of these molecules, including the important class of heat shock proteins; each entry is written by leading researchers in the field.
Heat Shock Response
Author | : Lutz Nover |
Publisher | : CRC Press |
Total Pages | : 532 |
Release | : 2022-09-09 |
Genre | : Science |
ISBN | : 1000714438 |
This book focuses on heat shock response-an active yet transient reprogramming of cellular activities to the needs of a stress protection mechanism designed to minimize heat damage and to optimize restoration of normal cellular activities after the stress period. This work places major emphasis on the structure and possible cellular functions of heat shock proteins as well as the analysis of heat shock protein-coding genes by transfection into homologous and heterologous expression systems. It also discusses heat shock effects on all levels of gene expression, on cell ultrastructure, and metabolic activities. This unique text is a must for all those who are involved with genetics, nucleic acids research, and cancer research.
Molecular Chaperones in Health and Disease
Author | : Matthias Gaestel |
Publisher | : Springer Science & Business Media |
Total Pages | : 464 |
Release | : 2005-09-27 |
Genre | : Science |
ISBN | : 9783540258759 |
Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.
Heat Shock Proteins in Cancer
Author | : Stuart K. Calderwood |
Publisher | : Springer Science & Business Media |
Total Pages | : 399 |
Release | : 2007-09-09 |
Genre | : Medical |
ISBN | : 1402064012 |
Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.