Test No. 478: Genetic Toxicology: Rodent Dominant Lethal Test

Test No. 478: Genetic Toxicology: Rodent Dominant Lethal Test
Author: OECD
Publisher: OECD Publishing
Total Pages: 6
Release: 1984-04-04
Genre:
ISBN: 9264071369

Dominant lethal (DL) effects cause embryonic or foetal death. Induction of a dominant lethal event after exposure to a test substance (liquid, solid, vapour or gas, ...) indicates that the substance has affected germinal tissue of the test species ...

Test No. 478: Rodent Dominant Lethal Test

Test No. 478: Rodent Dominant Lethal Test
Author: OECD
Publisher: OECD Publishing
Total Pages: 15
Release: 2015-07-28
Genre:
ISBN: 9264243119

The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl ...

OECD Series on Testing and Assessment Overview on genetic toxicology TGs

OECD Series on Testing and Assessment Overview on genetic toxicology TGs
Author: OECD
Publisher: OECD Publishing
Total Pages: 60
Release: 2017-04-13
Genre:
ISBN: 9264274766

Following a general update of the Genetic Toxicology TGs in 2015, the present Document was written to provide succinct and useful information to individuals unfamiliar with genetic toxicology testing, as well as experienced individuals wishing to obtain an overview of the recent changes that ...

Alternative Methodologies for the Safety Evaluation of Chemicals in the Cosmetic Industry

Alternative Methodologies for the Safety Evaluation of Chemicals in the Cosmetic Industry
Author: Nicola Loprieno
Publisher: CRC Press
Total Pages: 272
Release: 2019-08-15
Genre: Medical
ISBN: 1000693708

First published in 1995: Alternative Methodologies for the Safety Evaluation of Chemicals in the Cosmetic Industry presents a categorization and collection of information available for the evaluation of safety using in vitro techniques. It offers a comprehensive and complete look at the entire field. In doing so, the author provides the foundation for the next phase of significant growth for this discipline.

Principles of Toxicology Testing

Principles of Toxicology Testing
Author: Frank A. Barile
Publisher: CRC Press
Total Pages: 338
Release: 2007-07-23
Genre: Medical
ISBN: 1420008323

The evolution of toxicology testing finds its impetus in the continuing growth of the chemical and pharmaceutical industries, as well as the awareness of public health initiatives, needs, and responses that demand faster, more accurate, more economical methods for screening potential toxicity. Concurrent advances in biotechnology enable viable in v

Hamilton and Hardy's Industrial Toxicology

Hamilton and Hardy's Industrial Toxicology
Author: Raymond D. Harbison
Publisher: John Wiley & Sons
Total Pages: 1364
Release: 2015-04-13
Genre: Science
ISBN: 0470929731

Providing a concise, yet comprehensive, reference on all aspects of industrial exposures and toxicants; this book aids toxicologists, industrial hygienists, and occupational physicians to investigate workplace health problems. • Updates and expands coverage with new chapters covering regulatory toxicology, toxicity testing, physical hazards, high production volume (HPV) chemicals, and workplace drug use • Includes information on occupational and environmental sources of exposure, mammalian toxicology, industrial hygiene, medical management and ecotoxicology • Retains a succinct chapter format that has become the hallmark for the previous editions • Distils a vast amount of information into one resource for both academics and professionals

Translational Toxicology and Therapeutics

Translational Toxicology and Therapeutics
Author: Michael D. Waters
Publisher: John Wiley & Sons
Total Pages: 790
Release: 2018-01-04
Genre: Medical
ISBN: 1119023602

Written by leading research scientists, this book integrates current knowledge of toxicology and human health through coverage of environmental toxicants, genetic / epigenetic mechanisms, and carcinogenicity. Provides information on lifestyle choices that can reduce cancer risk Offers a systematic approach to identify mutagenic, developmental and reproductive toxicants Helps readers develop new animal models and tests to assess toxic impacts of mutation and cancer on human health Explains specific cellular and molecular targets of known toxicants operating through genetic and epigenetic mechanisms

Ullmann's Industrial Toxicology

Ullmann's Industrial Toxicology
Author: Wiley-VCH
Publisher: John Wiley & Sons
Total Pages: 1193
Release: 2005-10-28
Genre: Science
ISBN: 3527312471

The one-stop resource for health protection professionals, environmental scientists and safety engineers. Since the entire 40-volume Ullmann's Encyclopedia is inaccessible to many readers - particularly individuals, smaller companies or institutes - all the information on industrial toxicology, ecotoxicology, process safety as well as occupational health and safety has been condensed into this convenient 2-volume set. Based on the latest online edition of Ullmann's containing articles never been before in print, this ready reference provides practical information on applying the science of toxicology in both the occupational and environmental setting, and explains the fundamentals necessary for an understanding of the effects of chemical hazards on humans and ecosystems. The detailed and meticulously edited articles have been written by renowned experts from industry and academia, and much of the information has been thoroughly revised. Alongside explanations of safety regulations and legal aspects, this set covers food additives, toxic agents as well as medical and therapeutical issues. Top-quality illustrations, clear diagrams and charts combined with an extensive use of tables enhance the presentation and provide a unique level of detail. Deeper insights into any given area of interest is offered by referenced contributions, while rapid access to a particular subject is enhanced by both a keyword and author index.