Tendon Healing
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| Author | : Parmis Blomgran |
| Publisher | : Linköping University Electronic Press |
| Total Pages | : 59 |
| Release | : 2017-10-30 |
| Genre | : |
| ISBN | : 917685471X |
Tendons heal through three different overlapping phases; the inflammatory, proliferative and remodeling phase. Many studies have investigated what factors influence healing of tendons. However, little was known about inflammation and the immune cells present during Achilles tendon healing by the time this thesis started. We developed a flow cytometry method for our rat model of tendon healing, which enabled us to study different leukocyte subpopulations during Achilles tendon healing. The general aim of this thesis was to understand more about inflammation and the immune cell populations present during tendon healing and how the immune cell composition changes during normal tendon healing. Moreover, we investigated how different factors that are known to influence tendon healing affected the composition of the immune cell population. First, we described the immune cells during the time course of tendon healing focusing on different subpopulations of macrophages and T cells. Then, we studied how these cells were influenced by reduced mechanical loading. Mechanical loading prolonged the presence of M1 macrophages and delayed the switch to regulatory T cells and M2 macrophages compared to reduced mechanical loading. Next, the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on the leukocyte composition revealed that, even though NSAIDs influence the mechanical properties of healing tendon, this effect was not mediated via changes in the leukocyte sub-populations during early and mid-time tendon healing. Further, the effect of corticosteroids during the inflammatory and remodeling phases of tendon healing was an improved healing of tendons and a reduction of CD8a T cells when corticosteroid was administered after the inflammatory phase. Lastly, we investigated if impairment of tendon healing by NSAIDs was related to mechanotransduction or microdamage during mechanical loading and showed that NSAIDs impair tendon healing by reducing the response to microdamage. In conclusion, these studies show that inflammation plays an important role during Achilles tendon healing, and factors that influence healing can also alter the presence or polarization of immune cell populations.
| Author | : William R. Walsh |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 332 |
| Release | : 2007-10-28 |
| Genre | : Medical |
| ISBN | : 1592599427 |
A comprehensive and authoritative review of the most important scientific and clinically relevant topics today in ligaments, tendons, and capsular biology, including their biomechanics and surgical reconstruction. The authors review the basic science of tendons in the hand and shoulder ligaments, the current clinical status of the shoulder and cruciate ligaments, and the latest advances in research on the healing of ligament and tendon to bone, artificial ligaments, and gene therapy. They also cover the major type 1 collagen soft tissues that are of particular interest to upper extremity surgeons and sports medicine specialists.
| Author | : Nicola Maffulli |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 374 |
| Release | : 2005-02-09 |
| Genre | : Medical |
| ISBN | : 9781852335038 |
Tendon ailments are a significant cause of morbidity among athletes of all levels and are increasing in prevalence. Their management is often empirical, and para-scientific, only looking at the biological aspects of tendon ailments. This book conveys a comprehensive and concise body of knowledge on the management of tendon problems in sportspeople with practical details of clinical protocols. Tendon Injuries: Basic Science and Clinical Medicine is specifically dedicated to the clinical aspects of tendinopathy and provides the required knowledge and scientific basis for the sports medicine practitioner, orthopedic specialist and student facing upper and lower limb tendon ailments in athletes. A comprehensive review of tendon disorders is given and modern criteria of management outlined to form the basis of effective clinical management of this group of patients.
| Author | : Manuela E. Gomes |
| Publisher | : Academic Press |
| Total Pages | : 471 |
| Release | : 2015-08-08 |
| Genre | : Science |
| ISBN | : 0128016000 |
Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes is the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies. Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices. Contributions from scientists, clinicians, and engineers who are the leading figures in their respective fields present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field. - Provides an overview of tendon biology, disease, and tissue engineering approaches - Presents modern, alternative approaches to developing functional tissue solutions discussed - Includes valuable information for those interested in tissue engineering, tissue regeneration, tissue physiology, and regenerative medicine - Explores physiology, pathology, and surgical reconstruction, building a natural progression that enhances tendon regeneration practices - Covers recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field
| Author | : William Weintraub |
| Publisher | : |
| Total Pages | : 206 |
| Release | : 1999 |
| Genre | : Health & Fitness |
| ISBN | : |
Tendon and Ligament Healing describes how manual therapy can heal tendon and ligament injuries non-surgically. Weintraub presents his own manual therapy model.
| Author | : Jin Bo Tang |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 545 |
| Release | : 2012-06-15 |
| Genre | : Medical |
| ISBN | : 1455737429 |
Get the best results from the latest procedures with Tendon Surgery of the Hand, the only reference that offers comprehensive coverage of this complex and challenging area. World-renowned experts guide you through all of the newest techniques and technologies, equipping you to restore optimal function in your patients. It's your one-stop source for mastering today's best approaches to treating tendon injuries and disorders of the hand. - Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. - Successfully implement hot new repair techniques involving new suture materials, tendon sheath and pulley treatments, vascularized tendon grafts, and recent postoperative rehabilitation methods. - Improve your primary flexor tendon repair and rehabilitation treatment planning based on surgical and post-surgical care principles that clearly describe successful global methods and protocols. - Benefit from the collective knowledge and experience of an international group of surgeons, investigators, and therapists who offer unique and insightful techniques and advice. - See how to perform key techniques with exclusive operative videos online. - Access the complete contents online at expertconsult.com.
| Author | : Hajo Thermann |
| Publisher | : Springer |
| Total Pages | : 143 |
| Release | : 2017-04-20 |
| Genre | : Medical |
| ISBN | : 3662540746 |
This book, written by leading experts in the field, is a comprehensive guide to the best available techniques in Achilles tendon surgery. Each surgical procedure is described step by step, covering all of the approaches employed for the most common and important Achilles tendon pathologies. The clear descriptions are complemented by superb drawings prepared by a medical artist on the basis of photographs supplied by the authors. Pearls and possible pitfalls are identified to ensure optimal outcomes for patients. The book is the outcome of a collaboration among international Achilles tendon experts – the Achilles Tendon Study Group – that has already resulted in four other books on current concepts relating to the Achilles tendon. Like these previous volumes, The Achilles Tendon – An Atlas of Surgical Procedures is based on the highest level of evidence and expertise. It will be invaluable for orthopaedic surgeons, trauma surgeons, and residents, assisting them in their daily clinical work.
| Author | : Jón Karlsson |
| Publisher | : |
| Total Pages | : 426 |
| Release | : 2014 |
| Genre | : Achilles tendon |
| ISBN | : 9780955887345 |
| Author | : Gian Luigi Canata |
| Publisher | : Springer |
| Total Pages | : 440 |
| Release | : 2017-05-10 |
| Genre | : Medical |
| ISBN | : 366254184X |
This book explores in a comprehensive manner the causes and symptoms of muscle and tendon pathologies, the available diagnostic procedures, and current treatment approaches. Specific aspects of the anatomy, biomechanics, and function of muscles and tendons are analyzed, and detailed guidance is provided on the most innovative methods – both conservative and surgical – for ensuring that the athlete can make a safe and quick return to sporting activity. Optimal care of tendon and muscle injuries in sportspeople requires effective cooperation of sports scientists and medical practitioners to identify the best ways of preserving muscle and tendon structures and to develop new strategies for their rehabilitation and regeneration. Muscle and Tendon Injuries is an excellent multidisciplinary reference written by the leading experts in the field and published in collaboration with ISAKOS. It will appeal to all specialists in sports medicine and sports traumatology who are seeking a state of the art update on the management of muscle and tendon disorders.
| Author | : Heinz Redl |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2017-02-16 |
| Genre | : Technology & Engineering |
| ISBN | : 9783319088303 |
This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.
