This paper examines the potency Technical Vocational Education and Training (TVET) as a Panacea to Solving Nigeria's Youths' Problem of Unemployment. Nigeria, an emerging economy with an estimated population of about 200 million is battling with poverty and unemployment problems consequently the country's quest for technological progress, industrialization and economic development is 'snail-speeding' and very unimpressive. TVET has been recognized worldwide as a tool for empowering people, especially the youth, for sustainable livelihood and social-economic development. This paper adopted a conceptual approach to explore how Technical Vocational Education and Training as a Panacea to Solving Nigeria's Youths' Problem of Unemployment. Materials were generated via internet, textbooks and other documents relevant to the study. The Nigerian government had initiated several youth empowerment programmes through TVET, but a lot of these programmes lack structure and their impact not felt by the nation's youths. This is evident in the substantial number of youth that still lack work skills - which often results to unemployment, insecurity, loss of lives and properties and chaos. The findings based on the literature reviewed showed TVET is backed up with the availability of materials, infrastructure, hard and soft skills coupled with good will on the part of government could be the vitally needed solution to the problem of graduates' employability in Nigeria. Truly, the battle against youth unemployment cannot be won without tertiary institutions collaborating with the private sector of the economy. This forms the thrust of this paper. It was recommended among others that educational institutions offering technical education programmes should tap the dynamisms and synergies of the 21st century workplace to the full to produce technical education graduates who can fit in and succeed in the 21st century world of work.