T Box Genes In Limb Development And Disease
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| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 446 |
| Release | : 2017-01-02 |
| Genre | : Science |
| ISBN | : 0128016132 |
T-box Genes in Development and Disease looks at the genes encoding the T-box family of transcription factors function as key regulators of many important decision processes during embryonic and tissue development. The importance of these genes is further underlined by the fact that most members of this gene family have been conserved during evolution from worms to humans. This book brings together the current information on conserved aspects with the evolutionary innovations of the functions of these genes during developmental regulation in various animal species and then discusses their important roles in human disease. - Brings together current knowledge from a wide variety of animal species and humans - Presents commentary from authoritative experts, and includes many prominent scientists and their research - Illuminates the connections between developmental biology, evolution, and human disease - Allows researchers and newcomers to this research area to gain a thorough picture of the current knowledge
| Author | : Veronica van Heyningen |
| Publisher | : Academic Press |
| Total Pages | : 415 |
| Release | : 2011-09-02 |
| Genre | : Science |
| ISBN | : 0080877818 |
Long-Range Control of Gene Expression covers the current progress in understanding the mechanisms for genomic control of gene expression, which has grown considerably in the last few years as insight into genome organization and chromatin regulation has advanced. Discusses the evolution of cis-regulatory sequences in drosophila Includes information on genomic imprinting and imprinting defects in humans Includes a chapter on epigenetic gene regulation in cancer
| Author | : Sally A. Moody |
| Publisher | : Elsevier |
| Total Pages | : 1094 |
| Release | : 2007-07-19 |
| Genre | : Science |
| ISBN | : 0080550711 |
Unlike anything currently available in the market, Dr. Sally A. Moody and a team of world-renowned experts provide a groundbreaking view of developmental genetics that will influence scientific approaches in embryology, comparative biology, as well as the newly emerging fields of stem cell biology and regenerative medicine. Principles of Developmental Genetics highlights the intersection of developmental biology with new revolutionary genomic technologies, and details how these advances have accelerated our understanding of the molecular genetic processes that regulates development. This definitive resource provides researchers with the opportunity to gain important insights into the clinical applicability of emerging new technologies and animal model data. This book is a must-have for all researchers in genetics, developmental biology, regenerative medicine, and stem cell biology.• Includes new research not previously published in any other book on the molecular geneticprocesses that regulates development• Chapters present a broad understanding on the application of animal model systems, allowingresearchers to better treat clinical disorders and comprehend human development• Relates the application of new technologies to the manipulation of stem cells, causes ofhuman birth defects, and several human disease conditions• Each chapter includes a bulleted summary highlighting clinical aspects of animal models
| Author | : Toshio Nakanishi |
| Publisher | : Springer Nature |
| Total Pages | : 374 |
| Release | : 2020-02-28 |
| Genre | : Medical |
| ISBN | : 9811511853 |
This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.
| Author | : Matthew H. Kaufman |
| Publisher | : Academic Press |
| Total Pages | : 536 |
| Release | : 1992-09 |
| Genre | : Medical |
| ISBN | : |
Not since the early 1970s has there been an attempt to describe and illustrate the anatomy of the developing mouse embryo. More than ever such material is needed by biologists as they begin to unravel the molecular mechanisms underlying development and differentiation. After more than ten years of painstaking work, Matt Kaufman has completed The Atlas of Mouse Development--the definitive account of mouse embryology and development. For all those researching or studying mammalian development, The Atlas of Mouse Development will be the standard reference work for many years to come. Provides a comprehensive sequential account of the development of the mouse from pre-implantation to term Contains clear and concise descriptions of the anatomical features relevant to each stage of development Large format for easy use Contains explanatory notes and legends, and more than 180 meticulously labeled plates, 1,300 photographs of individual histological sections, and 200 electron micrographs, illustrating: Intermittent serial histological sections through embryos throughout embryogenesis and organogenesis Differentiation of specific organs and organ systems, including the spinal cord, eyes, gonads, kidneys, lungs and skeletal system External appearance of intact embryos throughout development
| Author | : Helen Sink |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 214 |
| Release | : 2007-02-26 |
| Genre | : Science |
| ISBN | : 0387329633 |
The different aspects of muscle development are considered from cellular, molecular and genetic viewpoints, and the text is supported by black/white and color illustrations. The book will appeal to those studying muscle development and muscle biology in any organism.
| Author | : Samia A. Temtamy |
| Publisher | : Alan R. Liss |
| Total Pages | : 596 |
| Release | : 1978 |
| Genre | : Medical |
| ISBN | : |
| Author | : Yamin Liu |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 166 |
| Release | : 2018-10-17 |
| Genre | : Medical |
| ISBN | : 1789842018 |
Polymorphism or variation in DNA sequence can affect individual phenotypes such as color of skin or eyes, susceptibility to diseases, and response to drugs, vaccines, chemicals, and pathogens. Especially, the interfaces between genetics, disease susceptibility, and pharmacogenomics have recently been the subject of intense research activity. This book is a self-contained collection of valuable scholarly papers related to genetic diversity and disease susceptibility, pharmacogenomics, ongoing advances in technology, and analytic methods in this field. The book contains nine chapters that cover the three main topics of genetic polymorphism, genetic diversity, and disease susceptibility and pharmacogenomics. Hence, this book is particularly useful to academics, scientists, physicians, pharmacists, practicing researchers, and postgraduate students whose work relates to genetic polymorphisms.
| Author | : Giacomina Brunetti |
| Publisher | : Frontiers Media SA |
| Total Pages | : 160 |
| Release | : 2020-03-24 |
| Genre | : |
| ISBN | : 2889636135 |
| Author | : Manzoor M. Khan |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 275 |
| Release | : 2008-12-19 |
| Genre | : Medical |
| ISBN | : 0387779760 |
During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.
