System And Methodology For Receptor Level Fluorescence Imaging During Surgery
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| Author | : Kristian J. Sexton |
| Publisher | : |
| Total Pages | : 400 |
| Release | : 2014 |
| Genre | : |
| ISBN | : |
e"Fluorescence molecular imaging will have an important clinical impact in the area of guided oncology surgery, where emerging technologies are poised to provide the surgeon with real-time molecular information to guide resection, using targeted molecular probes. The development of advanced surgical systems has gone hand in hand with probe development, and both aspects are analyzed in this work. A pulsed-light fluorescence guided surgical (FGS) system has been introduced to enable video rate visible light molecular imaging under normal room light conditions. The concepts behind this system design are presented and performance is compared with a commercial system in both phantom and in vivo animal studies using PpIX fluorescence. The second critical advance in the emergence of these technologies has been the development of targeted near infrared (NIR) probes. A small, engineered three-helix protein was analyzed for imaging of glioma tumors. The blood brain barrier affects delivery of probes and the superior delivery of a smaller targeted protein (anti-EGFR Affibody) as compared to a full sized antibody is shown using a murine model, ex vivo tissue slices and a commercial imaging system. This small targeted probe is examined further for its possible application in FGS using the pulsed light imaging system. A concentration sensitivity analysis to determine the lower bounds on concentration needed for effective imaging is performed with this culminating analysis carried out in a murine orthotopic glioma tumor model."
| Author | : Fernando D. Dip |
| Publisher | : Springer |
| Total Pages | : 357 |
| Release | : 2015-07-21 |
| Genre | : Medical |
| ISBN | : 3319156780 |
This text presents the experiences of leading researchers and surgeons with different fluorescence methods. Chapters range from basic science of fluorescence to current clinical applications and new horizons. The first few chapters describe the historical evolution and physical principles of fluorescence and provide the foundation for the reader to understand the current scope and limits of its use in surgery. The second section focuses on the clinical applications of intraoperative fluorescence imaging including subsections on fluorescence cholangiography, applications to hepatectomy, lymph node navigation, applications to GI tract and pelvic surgery and identification of cancer tissues. The third section focuses on new frontiers including fluorescence probes, imaging systems and applications to photodynamic therapy. Authored by leaders in the development of fluorescent methods worldwide, Fluorescence Imaging for Surgeons: Concepts and Applications will have an impact on numerous medical specialists including general surgeons, colorectal and minimally-invasive surgeons and surgical oncologists. Researchers will find the book to be an invaluable resource on the latest advances in the utilization of nanoparticles and fluorescent probes.
| Author | : WHO Classification of Tumours Editorial Board |
| Publisher | : International Agency for Research on Cancer |
| Total Pages | : 0 |
| Release | : 2019-11-21 |
| Genre | : Medical |
| ISBN | : 9789283245001 |
Table of contents : - TNM staging of carcinomas of the breast - 1. Introduction to tumours of the breast - 2. Epithelial tumours of the breast - 3. Fibroepithelial tumours and hamartomas of the breast - 4. Tumours of the nipple - 5. Mesenchymal tumours of the breast - 6. Haematolymphoid tumours of the breast - 7. Tumours of the male breast - 8. Metastases to the breast - 9. Genetic tumours syndromes of the breast.
| Author | : N. Kokudo |
| Publisher | : Karger Medical and Scientific Publishers |
| Total Pages | : 134 |
| Release | : 2013-09-10 |
| Genre | : Medical |
| ISBN | : 3318022934 |
Indocyanine green (ICG) fluorescence has been used for imaging purposes for more than half a century; First employed by ophthalmologists for visualizing the retinal artery in the late 1960s, the application of ICG fluorescence imaging has since been continuously expanded. Recently, advances in imaging technologies have led to renewed attention regarding the use of ICG in the field of hepatobiliary surgery, as a new tool for visualizing the biliary tree and liver tumors.
| Author | : Martin Zinkernagel |
| Publisher | : Springer |
| Total Pages | : 123 |
| Release | : 2019-07-29 |
| Genre | : Medical |
| ISBN | : 3030228789 |
This book focuses on the emerging non-invasive imaging technique of Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO). FLIO reveals unique information on retinal diseases, ranging from age-related macular degeneration and vascular diseases to hereditary retinal dystrophies. Fluorescence lifetimes enable the evaluation of disease progression before irreversible structural changes occur. The image acquisition is suitable for diagnostic purposes and follow-up examinations to investigate the natural course of disease, and to monitor the effects of possible therapies. This book fills the gap between available literature and gives state-of-the-art guidance on the principles of the FLIO technique, image acquisition, and data analysis. Written by a team of expert leaders within this field, this book will be relevant for scientists and clinicians with an interest in ophthalmoscopy.
| Author | : Robert Hoffman |
| Publisher | : Academic Press |
| Total Pages | : 296 |
| Release | : 2020-05-27 |
| Genre | : Medical |
| ISBN | : 0128126779 |
Strategies for Curative Fluorescence-Guided Surgery of Cancer is the first book to discuss how fluorescence-guided surgery can be successfully used during surgeries with several tumor types. FGS is one of the most exciting emerging modalities of surgery, especially cancer surgery, as it potentially allows the surgeon to visualize the actual margin of the tumor, thus greatly increasing the possibility of curative resection. The book discusses the applicability of FGS for several types of cancer, such as pancreatic cancer, liver metastasis, soft-tissue sarcoma, glioma, melanoma, and breast and lung cancer. This book is a valuable resource for cancer surgeons, cancer researchers and members of several other areas in the biomedical field who are interested in understanding this powerful technique. Presents an overview of fluorescence-guided surgery Explains general strategies for curative fluorescence-guided surgery and their applicability for each major tumor type Discusses the current and future achievements of FGS as a precise technique for cancer surgeries
| Author | : D. J. Terris |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2008-11-04 |
| Genre | : |
| ISBN | : 9783805589819 |
Thyroid surgery has undergone tremendous transformation in recent years, much of which has been technologically driven. Also the approach to the patient with hyperparathyroidism has similarly evolved to an operation that has little in common with the conventional neck exploration of just a decade ago. Highlights of this issue are contributions by leading experts in the field of thyroid surgery. State-of-the-art reviews on minimally invasive thyroid and parathyroid surgery as well as articles on novel approaches to the management of thyroid cancer are included. Further, new technology in thyroid surgery, the management of the central compartment in thyroid cancer, and intraoperative parathyroid hormone monitoring are discussed. Otolaryngologists and surgeons as well as endocrinologists, pediatric endocrinologists, and oncologists managing thyroid diseases will appreciate this comprehensive and timely update.
| Author | : |
| Publisher | : Newnes |
| Total Pages | : 4052 |
| Release | : 2014-07-25 |
| Genre | : Science |
| ISBN | : 0444536337 |
Comprehensive Biomedical Physics, Ten Volume Set is a new reference work that provides the first point of entry to the literature for all scientists interested in biomedical physics. It is of particularly use for graduate and postgraduate students in the areas of medical biophysics. This Work is indispensable to all serious readers in this interdisciplinary area where physics is applied in medicine and biology. Written by leading scientists who have evaluated and summarized the most important methods, principles, technologies and data within the field, Comprehensive Biomedical Physics is a vital addition to the reference libraries of those working within the areas of medical imaging, radiation sources, detectors, biology, safety and therapy, physiology, and pharmacology as well as in the treatment of different clinical conditions and bioinformatics. This Work will be valuable to students working in all aspect of medical biophysics, including medical imaging and biomedical radiation science and therapy, physiology, pharmacology and treatment of clinical conditions and bioinformatics. The most comprehensive work on biomedical physics ever published Covers one of the fastest growing areas in the physical sciences, including interdisciplinary areas ranging from advanced nuclear physics and quantum mechanics through mathematics to molecular biology and medicine Contains 1800 illustrations, all in full color
| Author | : Giuliano Mariani |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 319 |
| Release | : 2010-05-10 |
| Genre | : Medical |
| ISBN | : 0387383271 |
This multidisciplinary textbook is designed to be the standard on the subject and is geared for use by physicians who are involved in the care and/or diagnosis of cancer patients. Comprehensive coverage is provided on all aspects of radioguided surgery. Practical information is readily accessible and throughout there is an emphasis on improved decision making. Tables present the indications, performance, and interpretation of procedures at a glance. A wealth of illustrations, including a full-color insert, enhances the application of new concepts.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 222 |
| Release | : 2006-06-01 |
| Genre | : Science |
| ISBN | : 030916463X |
Scientists and engineers have long relied on the power of imaging techniques to help see objects invisible to the naked eye, and thus, to advance scientific knowledge. These experts are constantly pushing the limits of technology in pursuit of chemical imagingâ€"the ability to visualize molecular structures and chemical composition in time and space as actual events unfoldâ€"from the smallest dimension of a biological system to the widest expanse of a distant galaxy. Chemical imaging has a variety of applications for almost every facet of our daily lives, ranging from medical diagnosis and treatment to the study and design of material properties in new products. In addition to highlighting advances in chemical imaging that could have the greatest impact on critical problems in science and technology, Visualizing Chemistry reviews the current state of chemical imaging technology, identifies promising future developments and their applications, and suggests a research and educational agenda to enable breakthrough improvements.
