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| Author | : J. Allen |
| Publisher | : Wiley |
| Total Pages | : 990 |
| Release | : 1995-08-15 |
| Genre | : Science |
| ISBN | : 9780471951438 |
This work provides a forum for the exchange of information between leading scientists and manufacturers involved in the synthesis and applications of compounds labelled with radioactive and stable isotopes. Contains a general overview of the latest work in the field and its future significance.
| Author | : J. Allen |
| Publisher | : Wiley |
| Total Pages | : 956 |
| Release | : 1995-08-15 |
| Genre | : Science |
| ISBN | : 9780471951438 |
This work provides a forum for the exchange of information between leading scientists and manufacturers involved in the synthesis and applications of compounds labelled with radioactive and stable isotopes. Contains a general overview of the latest work in the field and its future significance.
| Author | : H.Gerhard Vogel |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 576 |
| Release | : 2010-12-15 |
| Genre | : Medical |
| ISBN | : 3540898905 |
Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".
| Author | : J. R. Heys |
| Publisher | : |
| Total Pages | : 776 |
| Release | : 1998-06-11 |
| Genre | : Reference |
| ISBN | : |
Synthesis and Applications of Isotopically Labelled Compounds provides a wide-ranging, authoritative and comprehensive coverage of the most recent advances in the synthesis, production and applications of stable and radioactive isotopes. This volume focuses on significant growth areas including applications of isotopes in clinical research and medicine, advances in the analysis of isotopically labelled compounds, novel approaches to compounds labelled with isotopes of hydrogen, applications of isotopes in organic and bio-organic reaction mechanisms, isotopes in macro-molecules, applications of isotopes in metabolism and toxicology, production of stable isotopes and radioisotopes and applications of isotopes in pharmaceutical and agricultural research. Contributions are drawn from major research groups around the world providing an invaluable information and reference source to anyone involved in the production of isotopes, the synthesis and analysis of stable or radioactive isotopically labelled compounds, the applications of short-lived isotopes, drug metabolism and pharmacokinetics, pharmaceutical research and development, clinical research, biosynthesis, handling radioisotopes, laboratory design and other related areas.
| Author | : D. C. Dean |
| Publisher | : |
| Total Pages | : 542 |
| Release | : 2004-08-27 |
| Genre | : Science |
| ISBN | : |
This volume provides an authoritative and comprehensive coverage of the most recent advances in the production, synthesis, analysis and applications of isotopically labelled compounds. It focuses especially on areas of significant growth since the immediately preceding Seventh International Isotope Society Meeting held in Dresden, Germany in June 2000. Contributions are drawn from major research groups around the world, providing valuable information to research community with interests in the following areas: New methodologies in the production of isotopes Novel synthetic and biosynthetic approaches to isotopically labelled compounds Analysis of isotopically labeled compounds Application of isotopically labelled compounds in medical, agricultural, nutritional and environmental research and development Investigation and elucidation or organic and bioorganic mechanisms and pathways Regulatory and safety perspectives The next Symposium in this series will be held at Edinburgh, Scotland in the summer of 2006.
| Author | : John Christopher Cornell |
| Publisher | : World Scientific |
| Total Pages | : 894 |
| Release | : 1996-06-12 |
| Genre | : |
| ISBN | : 9814547972 |
These conference proceedings will be of interest to all accelerator scientists and engineers, as well as those concerned with the application of cyclotrons in various fields. The conference covers the latest developments in the science, technology and use of cyclotrons, and includes more than 25 invited talks by specialists in their respective fields. Contributions include papers on newly operating cyclotrons and facilities under construction, compact cyclotrons, cooler rings and post-accelerators, ion sources, beam dynamics, beam diagnostics, cyclotron components, systems and technologies, as well as medical applications — including radiotherapy and radioisotope production — non-medical applications, radioactive beam facilities and new projects and proposals.
| Author | : Ulrich Pleiss |
| Publisher | : |
| Total Pages | : 736 |
| Release | : 2001-03-28 |
| Genre | : Science |
| ISBN | : |
This outstanding book covers the most recent advances in the production of stable and radioactive isotopes as well as in the synthesis, analysis and applications of isotopically labelled compounds. Written by internationally renowned contributors, it provides authoritative and wide-ranging coverage of significant growth areas including: * new methodologies in the production of isotopes * novel approaches to compounds labelled with isotopes of hydrogen, carbon and other stable, long-lived and short-lived radioactive isotopes * advances in the analysis of istopically labelled compounds * recent and future applications of isotopes in pharmaceutical research and development, in pharmacological and clinical sutdies and nuclear medicine, as well as in agricultural, nutritional and environmental research * recent applications of isotopes in investigating organic and bioorganic mechanisms and pathways * safety and regulations of handling isotopes This will be an invaluable information and reference source to anyone involved in the production of isotopes, the synthesis and analysis of compounds labelled with stable, long-lived or short-lived radioactive isotopes, in drug research and development, in clinical investigations and nuclear medicine, in agricultural research and development and environmental investigations, in the elucidation of biological and chemical pathways, handling radioisotopes, laboratory design and other areas.
| Author | : Rolf Voges |
| Publisher | : John Wiley & Sons |
| Total Pages | : 682 |
| Release | : 2009-03-12 |
| Genre | : Science |
| ISBN | : 9780470743430 |
Compounds labeled with carbon-14 and tritium are indispensable tools for research in biomedical sciences, discovery and development of pharmaceuticals and agrochemicals. Preparation of Compounds Labeled with Tritium and Carbon-14 is a comprehensive, authoritative and up-to-date discussion of the strategies, synthetic approaches, reactions techniques, and resources for the preparation of compounds labeled with either of these isotopes. A large number of examples are presented for the use of isotopic sources and building blocks in the preparation of labeled target compounds, illustrating the range of possibilities for embedding isotopic labels in selected moieties of complex structures. Topics include: Formulation of synthetic strategies for preparing labeled compounds Isotope exchange methods and synthetic alternatives for preparing tritiated compounds In-depth discussion of carbon-14 building blocks and their utility in synthesis Preparation of enantiomerically pure isotopically labeled compounds Applications of biotransformations Preparation of Compounds Labeled with Tritium and Carbon-14 is an essential guide to the specialist strategies and tactics used by chemists to prepare compounds tagged with theradioactive atoms carbon-14 and tritium.
| Author | : Atta-ur Rahman |
| Publisher | : Elsevier |
| Total Pages | : 1365 |
| Release | : 1998-12-03 |
| Genre | : Science |
| ISBN | : 0080541992 |
Natural Products Chemistry continues to grow at an increasing pace and this growth is reflected in the present volume of Studies in Natural Products Chemistry, which is the 20th of this series. The first 20 volumes were largely devoted to structure and synthesis of various classes of natural products, irrespective of their bioactivity. Subsequent volumes of this series will however be devoted to the chemistry of bioactive natural products and will therefore a departure from the earlier volumes.The present volume contains contributions from a number of eminent scientists and covers interesting reviews on terpenes, alkaloids and other types of natural products reported from terrestrial and marine sources. Comprehensive indexes covering all the 20 volumes have been prepared which include a Cumulative General Subject Index along with more focused Cumulative Indices on Organic Synthesis, Pharmacological Activity and Biological Source. This comprehensive indexing of the volumes should make the entire series much more valuable and user-friendly.
| Author | : John Christopher Cornell |
| Publisher | : World Scientific |
| Total Pages | : 894 |
| Release | : 1996 |
| Genre | : Cyclotrons |
| ISBN | : 9814531308 |
