Synthesis and Application of Targeted Molecular Imaging Agents for Enhanced Disease Imaging and Therapy
| Author | : Mingfeng Bai |
| Publisher | : |
| Total Pages | : 162 |
| Release | : 2007 |
| Genre | : Antineoplastic agents |
| ISBN | : |
Synthesis And Application Of Targeted Molecular Imaging Agents For Enhanced Disease Imaging And Therapy
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Handbook of Targeted Delivery of Imaging Agents
| Author | : Vladimir P. Torchilin |
| Publisher | : CRC Press |
| Total Pages | : 762 |
| Release | : 1995-08-23 |
| Genre | : Medical |
| ISBN | : 9780849383083 |
This is the first time detailed and updated information on the targeted delivery of imaging agents has been collected into a single handbook. This comprehensive volume presents the scientific background together with the latest experimental and clinical data in this fast-growing area. The Handbook of Targeted Delivery of Imaging Agents meets the requirements of the broadest audience including researchers, practitioners, and students. The basic principles of targeted delivery of imaging are presented and discussed together with various imaging agents and different imaging modalities such as gamma-imaging, MR-imaging, and CT, PET, and SPECT imaging. The book consists of eight parts and 39 chapters covering all aspects of targeted drug delivery-from the imaging theory and chemistry of imaging agents to their experimental and clinical use for targeted visualization of cancer, including ovarian, prostate, colorectal, and thyroid cancer, cardiovascular (atherosclerosis, myocardial infarction, and thromboses) and neurological diseases, infection, and inflammation sites. A special section discusses the targeted delivery of imaging agents into lymph nodes, which are often sites of metasteses during different malignant diseases. Monoclonal antibody-based targeted imaging agents are considered together with new approaches involving the use of labeled micelles, liposomes, and polymer-coated particles. The book describes the possible application of designer antibodies for the delivery of diagnostic agents, including the preparation, properties, labeling, and experimental use of multifunctional antibodies. The alternative improvement of antibody-directed targeting describes the application of avidin-biotin system for the delivery of imaging agents. Long circulating blood pool imaging agents are considered as a special group of organ-specific pharmaceuticals. The latest trends in the synthesis of immunoscintigraphic, MR, and CT agents are presented. This Handbook of Targeted Delivery of Imaging Agents is a must-have reference for all those who need to stay abreast of the latest developments in this hot field.
Modular Synthesis of Dual- and Tri-modal Targeted Molecular Imaging Agents
| Author | : Nicholas C. Schug |
| Publisher | : |
| Total Pages | : 105 |
| Release | : 2020 |
| Genre | : Cancer |
| ISBN | : |
"There are few reported methods for combining two or three different imaging dyes, metals, or dye-metal combinations, followed by the conjugation of a disease- targeting group to enable the use a given imaging system for multiple imaging applications. Previously, peptides have been used as scaffolds for dyes and metals used in diagnostic techniques such as optical molecular imaging (OMI), positron emission tomography (PET), and magnetic resonance imaging (MRI). The aim of this project was to reassemble peptide-based imaging agents through a modular method by coupling together modules comprised of amino acids with imaging agents attached to their side chains to form “imaging peptides,” followed by attaching a cancer-targeting group in the final step. This new modular approach for the synthesis of a diverse set of targeted molecular imaging agents (TMIAs) was optimized and exemplified by the synthesis of dual modal PET-MRI, dual OMI-MRI and dual metal (di-gadolinium for MRI), and the partial synthesis of a tri-modal OMI-PET-MRI agent. The dual modal imaging peptides were conjugated through a linker to targeting groups for lung cancer (A549 cells) and prostate cancer (PSMA positive C4-2) cells. In addition to imaging applications for early detection, active surveillance, image guided biopsies and surgery, this modular approach could potentially be used for creating therapeutic agents to treat cancer patients."--Abstract.
Molecular Imaging in Oncology
| Author | : Otmar Schober |
| Publisher | : Springer Nature |
| Total Pages | : 911 |
| Release | : 2020-06-27 |
| Genre | : Medical |
| ISBN | : 3030426181 |
This book discusses the most significant recent advances in oncological molecular imaging, covering the full spectrum from basic and preclinical research to clinical practice. The content is divided into five sections, the first of which is devoted to standardized and emerging technologies and probe designs for different modalities, such as PET, SPECT, optical and optoacoustic imaging, ultrasound, CT, and MRI. The second section focuses on multiscale preclinical applications ranging from advanced microscopy and mass spectroscopy to whole-body imaging. In the third section, various clinical applications are presented, including image-guided surgery and the radiomic analysis of multiple imaging features. The final two sections are dedicated to the emerging, crucial role that molecular imaging can play in the planning and monitoring of external and internal radiotherapy, and to future challenges and prospects in multimodality imaging. Given its scope, the handbook will benefit all readers who are interested in the revolution in diagnostic and therapeutic oncology that is now being brought about by molecular imaging.
The Chemistry of Molecular Imaging
| Author | : Nicholas Long |
| Publisher | : John Wiley & Sons |
| Total Pages | : 431 |
| Release | : 2014-11-24 |
| Genre | : Technology & Engineering |
| ISBN | : 1118854810 |
Molecular imaging is primarily about the chemistry of novel biological probes, yet the vast majority of practitioners are not chemists or biochemists. This is the first book, written from a chemist's point of view, to address the nature of the chemical interaction between probe and environment to help elucidate biochemical detail instead of bulk anatomy. Covers all of the fundamentals of modern imaging methodologies, including their techniques and application within medicine and industry Focuses primarily on the chemistry of probes and imaging agents, and chemical methodology for labelling and bioconjugation First book to investigate the chemistry of molecular imaging Aimed at students as well as researchers involved in the area of molecular imaging
Molecular Imaging: Basic Principles And Applications In Biomedical Research
| Author | : Markus Rudin |
| Publisher | : World Scientific |
| Total Pages | : 564 |
| Release | : 2005-09-29 |
| Genre | : Science |
| ISBN | : 1783260378 |
Molecular imaging is a rapidly emerging field that translates many concepts developed for molecular biology and cellular imaging to the in vivo imaging of intact organisms. The technique allows the study of molecular biological events in their full context and will therefore become an indispensable tool for biomedical research and drug discovery and development.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities and the design of target reporter constructs are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events: the biodistribution of drugs/ligands, the expression of drug targets (receptors, enzymes), and the consequences of the molecular drug-target interactions (pathway activations, system responses). A final chapter deals with visualization of cell migration (cell therapies).
Molecular Imaging Probes for Cancer Research
| Author | : Xiaoyuan Chen |
| Publisher | : World Scientific |
| Total Pages | : 1102 |
| Release | : 2012 |
| Genre | : Medical |
| ISBN | : 9814293679 |
This review volume integrates the advances in cancer biology, molecular imaging techniques and imaging probes for visualization and quantitative measurement of anatomical, functional, and molecular profiles of cancer. The volume also presents a comprehensive summary of the state-of-the-art technology in molecular imaging probe design and applications in radionuclide (PET and SPECT), magnetic resonance (MR), optical (fluorescence, Raman, photoacoustic), ultrasound, CT, and multimodality imaging. Bringing together the fundamentals of molecular imaging, and the basic principles of each molecular imaging modality in this volume, readers' understanding in this field is further enhanced. With a strong emphasis on the chemistry of the design of appropriate molecular imaging probes for early cancer detection, therapy-response monitoring, and anti-cancer drug development, the process of translating novel cancer imaging probes from bench to bedside is extensively discussed.
Nanoplatform-Based Molecular Imaging
| Author | : Xiaoyuan Chen |
| Publisher | : John Wiley & Sons |
| Total Pages | : 848 |
| Release | : 2011-04-20 |
| Genre | : Technology & Engineering |
| ISBN | : 1118110021 |
The cutting-edge guide on advancing the science of molecular imaging using nanoparticles Nanoplathform-Based Molecular Imaging provides rationale for using nanoparticle-based probes for molecular imaging, then discusses general strategies for this underutilized, yet promising, technology. It addresses general strategies of particle synthesis and surface chemistry, applications in computed tomography optical imaging, magnetic resonance imaging, ultrasound, multimodality imaging, theranostics, and finally, the clinical perspectives of nanoimaging. This comprehensive volume summarizes the opinions of those in the forefront of research and describes the latest developments by emphasizing fundamentals and initiating hands-on application.
The Chemistry of Imaging Probes
| Author | : Lorenzo Tei |
| Publisher | : Frontiers Media SA |
| Total Pages | : 129 |
| Release | : 2018-10-19 |
| Genre | : |
| ISBN | : 288945598X |
Over the past decades, the field of molecular imaging has been rapidly growing involving multiple disciplines such as medicine, biology, chemistry, pharmacology and biomedical engineering. Any molecular imaging procedure requires an imaging probe that is an agent used to visualize, characterize and quantify biological processes in living systems. Such a probe typically consists of an agent that usually produces signal for imaging purpose, a targeting moiety, and a linker connecting the targeting moiety and the signaling agent. Many challenging problems of molecular imaging can be addressed by exploiting the great possibilities offered by modern synthetic organic and coordination chemistry and the powerful procedures provided by conjugation chemistry. Thus, chemistry plays a decisive role in the development of this cutting-edge methodology. Currently, the diagnostic imaging modalities include Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Ultrasound (US), Nuclear Imaging (PET, SPECT), Optical Imaging (OI) and Photoacoustic Imaging (PAI). Each of these imaging modalities has its own advantages and disadvantages, and therefore, a multimodal approach combining two techniques is often adopted to generate complementary anatomical and functional information of the disease. The basis for designing imaging probes for a given application is dictated by the chosen imaging modality, which in turn is dependent upon the concentration and localization profile (vascular, extracellular matrix, cell membrane, intracellular, near or at the cell nucleus) of the target molecule. The development of high-affinity ligands and their conjugation to the targeting vector is also one of the key steps for pursuing efficient molecular imaging probes. Other excellent reviews, text and monographs describe the principles of biomedical imaging, focusing on molecular biology or on the physics behind the techniques. This Research Topic aims to show how chemistry can offer molecular imaging the opportunity to express all its potential.
