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| Author | : Xinyi Zhang |
| Publisher | : |
| Total Pages | : 526 |
| Release | : 2018 |
| Genre | : Synchrotron radiation |
| ISBN | : 9789813227668 |
"The book contains the latest synchrotron-based techniques and research results. All contributors are specialists or leading scientists in their fields. The book includes new techniques and methods that will potentially get wider applications in various disciplines"--
| Author | : R. Sweet |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 354 |
| Release | : 2013-03-09 |
| Genre | : Technology & Engineering |
| ISBN | : 1468480413 |
The development of synchrotron radiation (SR) as a research tool was driven largely by the needs of materials scientists and solid-state physi cists. However, the availability of SR has extended significantly the capa bility of scientists who study biological structure with radiation. This volume contains some of the results reported at a symposium held at Brookhaven National Laboratory in May 1988 to discuss the application of synchrotron radiation to structural biology. We are grateful for financial support from the u. s. Department of Energy, the National Institutes of Health, Genentech, Inc., Blake Indus tries, Inc., Evans and Sutherland Co., The Upjohn Company, Eli Lilly and Company, Enraf-Nonius Service Corp., and Associated Universities, Inc. We warmly thank Ms. Nancy Siemon for her tireless efforts with correspondence and the manuscripts for this symposium volume. Symposium Committee: Robert M. Sweet, Chair Malcolm S. Capel Benno P. Schoenborn John C. Sutherland Elizabeth C. Theil Stephen W. White Avril D. Woodhead Helen Z. Kondratuk, Coordinator v CONTENTS An Introduction to the Symposium . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 R. M. Sweet SYMPOSIUM LECTURE Developments in X-ray Technology and Their Contribution to Structural Biology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 H. E. Huxley SOME OF THE SYNCHROTRON FACILITIES FOR BIOLOGICAL STRUCTURAL STUDIES MacChess - A Macromolecular Diffraction Resource at the Cornell High Energy Synchrotron Source . . . . . . . . . . . . . . . . . . . 15 W. Schi1dkamp, K. Moffat, B. Batterman, D. Bilderback, T-Y. Teng, A. LeGrand and D. Szebenyi Facilities Available for Biophysics Research at the Stanford Synchrotron Radiation Laboratory. . . . . . . . . . . . . . . . . . . . . 19 R. P."
| Author | : Bonnie Ann Wallace |
| Publisher | : IOS Press |
| Total Pages | : 244 |
| Release | : 2009 |
| Genre | : Medical |
| ISBN | : 1607500000 |
Presents an account of circular dichroism (CD) spectroscopy and its application to structural biology. This book covers the methods of synchrotron radiation circular dichroism (SRCD) and linear dichroism (LD).
| Author | : Dava Sobel |
| Publisher | : Bloomsbury Publishing USA |
| Total Pages | : 209 |
| Release | : 2010-07-05 |
| Genre | : Biography & Autobiography |
| ISBN | : 0802779433 |
The dramatic human story of an epic scientific quest and of one man's forty-year obsession to find a solution to the thorniest scientific dilemma of the day--"the longitude problem." Anyone alive in the eighteenth century would have known that "the longitude problem" was the thorniest scientific dilemma of the day-and had been for centuries. Lacking the ability to measure their longitude, sailors throughout the great ages of exploration had been literally lost at sea as soon as they lost sight of land. Thousands of lives and the increasing fortunes of nations hung on a resolution. One man, John Harrison, in complete opposition to the scientific community, dared to imagine a mechanical solution-a clock that would keep precise time at sea, something no clock had ever been able to do on land. Longitude is the dramatic human story of an epic scientific quest and of Harrison's forty-year obsession with building his perfect timekeeper, known today as the chronometer. Full of heroism and chicanery, it is also a fascinating brief history of astronomy, navigation, and clockmaking, and opens a new window on our world.
| Author | : Chunhai Fan |
| Publisher | : John Wiley & Sons |
| Total Pages | : 846 |
| Release | : 2018-05-29 |
| Genre | : Technology & Engineering |
| ISBN | : 3527339868 |
Meeting the long-felt need for in-depth information on one of the most advanced material characterization methods, a top team of editors and authors from highly prestigious facilities and institutions covers a range of synchrotron techniques that have proven useful for materials research. Following an introduction to synchrotron radiation and its sources, the second part goes on to describe the various techniques that benefit from this especially bright light, including X-ray absorption, diffraction, scattering, imaging, and lithography. The thrid and final part provides an overview of the applications of synchrotron radiation in materials science. bridging the gap between specialists in synchrotron research and material scientists, this is a unique and indispensable resource for academic and industrial researchers alike.
| Author | : Jean-Paul Renaud |
| Publisher | : John Wiley & Sons |
| Total Pages | : 1437 |
| Release | : 2020-01-09 |
| Genre | : Medical |
| ISBN | : 1118900502 |
With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins
| Author | : H. Saisho |
| Publisher | : Elsevier |
| Total Pages | : 511 |
| Release | : 1996-08-02 |
| Genre | : Science |
| ISBN | : 0080527418 |
Synchroton radiation (SR) is utilized in most scientific fields. This book will therefore be useful not only for researchers engaged in analytical chemistry, and those studying the basic fields such as physics, chemistry, biology, as well as earth science, medicine, and life science but also for those engaged in research for elucidating structure of material and its function in the application fields including applied physics, semiconductor engineering, and metal engineering. The book has a highly interdisciplinary character. The outstanding characteristics of SR have also contributed to the rapid development of new fields and applications in analytical chemistry.Features of this book:• Explains the basics of SR• Facilities and instrumentation are covered to facilitate the planning of experiments using SR.• Aspects for the future development of SR are included together with an introduction to the latest techniques which are expected to find increasing use in the coming years.This book should stimulate students specializing in analytical chemistry and materials science to have an interest in SR. In addition, it will provide scientists who are beginning analytical chemistry research using SR with instructive and illustrative descriptions. The book can also be used as an explanatory text for advanced research on the application of SR.
| Author | : Herman Winick |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 767 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1461579988 |
This book has grown out of our shared experience in the development of the Stanford Synchrotron Radiation Laboratory (SSRL), based on the electron-positron storage ring SPEAR at the Stanford Linear Accelerator Center (SLAC) starting in Summer, 1973. The immense potential of the photon beam from SPEAR became obvious as soon as experiments using the beam started to run in May, 1974. The rapid growth of interest in using the beam since that time and the growth of other facilities using high-energy storage rings (see Chapters 1 and 3) demonstrates how the users of this source of radiation are finding applications in an increasingly wide variety of fields of science and technology. In assembling the list of authors for this book, we have tried to cover as many of the applications of synchrotron radiation, both realized already or in the process of realization, as we can. Inevitably, there are omissions both through lack of space and because many projects are at an early stage. We thank the authors for their efforts and cooperation in producing what we believe is the most comprehensive treatment of synchrotron radiation research to date.
| Author | : Keith Moffat |
| Publisher | : John Wiley & Sons |
| Total Pages | : 292 |
| Release | : 2023-10-19 |
| Genre | : Science |
| ISBN | : 1119696305 |
Dynamics and Kinetics in Structural Biology Understand the latest experimental tools in structural biology with this pioneering work Structural biology seeks to understand the chemical mechanisms and functions of biological molecules, such as proteins, based on their atomic structures. Until recently, these structures have been studied only statically, using procedures which deliberately freeze atomic motion. However, freezing eliminates the rapid structural motions so essential to biological activity and function; the molecules are inactive. But with the recent development of X-ray free electron laser (XFEL) sources, efforts to conduct dynamic experiments have expanded using the principles of dynamics and kinetics to capture active biological molecules as they function. Dynamics and Kinetics in Structural Biology promotes the development of these experiments and their successful application. It grounds readers in the foundational principles of dynamics and kinetics; proceeds through extended discussions of experimental procedures and data analysis techniques; and explores experimental frontiers in structural dynamics. The book will aid researchers to gather and interpret cutting-edge data on the dynamic structure of biological molecules, under conditions where they retain their biological functions. Dynamics and Kinetics in Structural Biology offers readers: Authorship by founding figures in the field In-depth presentation of time-resolved X-ray crystallography, solution scattering, and more A pioneering contribution to a rapidly developing field of study Dynamics and Kinetics in Structural Biology is essential reading for graduate students, scientists, researchers and industry professionals engaged in structural studies of biological systems. Industry professionals considering dynamic studies in the development of new product lines will also benefit.
| Author | : John R. Helliwell |
| Publisher | : Cambridge University Press |
| Total Pages | : 620 |
| Release | : 1992 |
| Genre | : Science |
| ISBN | : 0521544041 |
This highly illustrated monograph provides a comprehensive treatment of the study of the structure and function of the molecules of life--proteins, nucleic acids, and viruses--using synchrotron radiation and crystallography. Beginning with chapters on the fundamentals of macromolecular crystallography and macromolecular structure, the book goes on to review the sources and properties of synchrotron radiation, instrumentation, and monochromatic data collection. There are also chapters on the Laue method, on diffuse X-ray scattering, and on variable wavelength anomalous dispersion methods. The book concludes with a description and survey of applications including studies at high resolution, the use of small crystals, the study of large unit cells, and time-resolved crystallography (particularly of enzymes). Appendices are provided that present essential information for the synchrotron user as well as information about synchrotron facilities currently available.
