This book entitled as Practical Manual of Gunapadam Marunthiyal (Purification of Herbal, Mineral and Animal Origin Drugs) deals with various aspects of practical guidelines for purification of raw materials from medicinally useful herbs, minerals and animal products. It covers the procedure for the individual raw materials which are already mentioned in the Siddha ancient classical literatures. It dealt with the method of purification, required raw drugs and equipment used in the process and with medicinal uses, references at the end. By knowing purification methods well, we are able to remove the various toxic compounds from Scheduled E drugs like Cherankottai, Nervalam and to potentiate as well as enhance the therapeutic properties of the other raw drugs. As Gunapadam Marunthiyal is a compulsory subject for the Second year B.S.M.S students, we covered all the possible topics which will help the students in their exam point of view as well as in medicine preparation of their own clinical practice in future. As Siddhar Agathiyar said “Marunthu suddhi gunam nigandu kanngal moondram", Medicines prepared from purified raw materials should be safe for the usage in treating the diseases.