In an age where we are inundated with information, the ability to discern verifiable information to make proper decisions and solve problems is ever more critical. Modern science, which espouses a systematic approach to making “inferences,” requires a certain mindset that allows for a degree of comfort with uncertainty. This book offers inspirations and ideas for cultivating the proper mindset for the studying, teaching, and practicing of science that will be useful for those new to as well as familiar with the field. Although a paradigm shift from traditional instruction is suggested in the National Framework for K-12 science, this volume is intended to help educators develop a personal mental framework in which to transition from a teacher-centered, didactical approach to a student-centered, evidence-guided curriculum. While the topics of the book derive from currently published literature on STEM education as they relate to the National Framework for K-12 Science and the Three-Dimensional science instruction embedded in the Next Generation Science Standards, this book also examines these topics in the context of a new societal age posited as the “Age of Inference” and addresses how to make sense of the ever-increasing deluge of information that we are experiencing by having a scientific and properly discerning mindset. ENDORSEMENTS: "This volume takes on one of the thorniest existential problems of our time, the contradiction between the exponentially growing amount of information that individuals have access to, and the diminished capacity of those individuals to understand it. Its chapters provide the reader with an introduction to the relationship between knowledge, science, and inference; needed new approaches to learning science in our new data rich world; and a discussion of what we can and must do to reduce or eliminate the growing gap between the inference have’s and have nots. It is not too much to say that how we resolve the issues outlined in this volume will determine the future of our species on this planet." — Joseph L. Graves Jr., Professor of Biological Sciences North Carolina A&T State University, Fellow, American Association for the Advancement of Science: Biological Sciences, Author of: The Emperor’s New Clothes: Biological Theories of Race at the Millennium "Big data is not enough for addressing dangers to the environment or tackling threats to democracy; we need the ability to draw sound inferences from the data. Cultivating a scientific mindset requires fundamental changes to the way we teach and learn. This important and well -written volume shows how." — Ashok Goel, Professor of Computer Science and Human Centered Computing, Georgia Institute of Technology. Editor of AI Magazine Founding Editor of AAAI’s Interactive AI Magazine "If you are a science teacher concerned about the implications of information overload, analysis paralysis, and intellectual complacency on our health, economic future, and democracy, then I recommend this book." — Michael Svec, Professor for Physics and Astronomy Education, Furman University, Fulbright Scholar to Czech Republic