Studies Towards The Synthesis Of Potential Serine Protease Inhibitors
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Design, Synthesis, and Structure-activity Relationships Analysis of Potential Inhibitors of the Serine Protease Thrombin and the Malarial Aspartic Proteases Plasmepsin I and II
Author | : Anders Dahlgren |
Publisher | : |
Total Pages | : 58 |
Release | : 2002 |
Genre | : |
ISBN | : 9789173734486 |
Design and Synthesis of Serine and Aspartic Protease Inhibitors
Author | : Fredrik Wångsell |
Publisher | : |
Total Pages | : 66 |
Release | : 2006 |
Genre | : |
ISBN | : 9789185523214 |
Serpin Structure and Evolution
Author | : James Whisstock |
Publisher | : Academic Press |
Total Pages | : 562 |
Release | : 2011-11-16 |
Genre | : Medical |
ISBN | : 0123859506 |
Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. This volume in the Methods in Enzymology series comprehensively covers this topic. With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems. This volume in the Methods in Enzymology series comprehensively covers the topic of serpins With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems
Activation of Viruses by Host Proteases
Author | : Eva Böttcher-Friebertshäuser |
Publisher | : Springer |
Total Pages | : 337 |
Release | : 2018-05-22 |
Genre | : Medical |
ISBN | : 3319754742 |
This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.
Extracellular Targeting of Cell Signaling in Cancer
Author | : James W. Janetka |
Publisher | : John Wiley & Sons |
Total Pages | : 482 |
Release | : 2018-07-23 |
Genre | : Science |
ISBN | : 1119300185 |
International experts present innovative therapeutic strategies to treat cancer patients and prevent disease progression Extracellular Targeting of Cell Signaling in Cancer highlights innovative therapeutic strategies to treat cancer metastasis and prevent tumor progression. Currently, there are no drugs available to treat or prevent metastatic cancer other than non-selective, toxic chemotherapy. With contributions from an international panel of experts in the field, the book integrates diverse aspects of biochemistry, molecular biology, protein engineering, proteomics, cell biology, pharmacology, biophysics, structural biology, medicinal chemistry and drug development. A large class of proteins called kinases are enzymes required by cancer cells to grow, proliferate, and survive apoptosis (death) by the immune system. Two important kinases are MET and RON which are receptor tyrosine kinases (RTKs) that initiate cell signaling pathways outside the cell surface in response to extracellular ligands (growth factors.) Both kinases are oncogenes which are required by cancer cells to migrate away from the primary tumor, invade surrounding tissue and metastasize. MET and RON reside on both cancer cells and the support cells surrounding the tumor, called the microenvironment. MET and RON are activated by their particular ligands, the growth factors HGF and MSP, respectively. Blocking MET and RON kinase activation and downstream signaling is a promising therapeutic strategy for preventing tumor progression and metastasis. Written for cancer physicians and biologists as well as drug discovery and development teams in both industry and academia, this is the first book of its kind which explores novel approaches to inhibit MET and RON kinases other than traditional small molecule kinase inhibitors. These new strategies target key tumorigenic processes on the outside of the cell, such as growth factor activation by proteases. These unique strategies have promising potential as an improved alternative to kinase inhibitors, chemotherapy, or radiation treatment.