Structure Function And Biomedical Inhibition Of Two Alzheimers Disease Related Acetyltransferases Atase1 And Atase2
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The Pancreas
| Author | : John A. Williams |
| Publisher | : Michigan Publishing Services |
| Total Pages | : 0 |
| Release | : 2021 |
| Genre | : Medical |
| ISBN | : 9781607857167 |
This book provides comprehensive and definitive coverage of the current understanding of the structure and function of the exocrine pancreas. While emphasis is on normal physiology, the relevant cell biological, developmental and biochemical information is also provided. Where appropriate, chapters also include material on functional changes in pancreatitis. All chapters are fully referenced and provide up to date information. The book has been overseen and published by the American Pancreatic Association with Fred S. Gorelick and John A. Williams as Editors. It includes 26 chapters written by an international group of authorities; completed chapters are also presented in open access format on the Pancreapedia (www.pancreapedia.org). The book contains full-color images and summary diagrams that enhance readability and extend the detail provided in the text. The Pancreas: Biology and Physiology is divided into four sections: Pancreatic Exocrine Structure and Function Anatomy, Bioenergetics, Cytoskeleton, Intracellular Signaling Acinar Cells Digestive enzyme synthesis, intracellular transport, Zymogen granules, Exocytosis Exocrine Pancreas Integrative Responses Hormonal and Neural Control of Protein and Fluid Secretion, Molecular mechanisms of fluid and bicarbonate secretion, regulation of growth and regeneration Pancreatic Islet and Stellate Cell Structure and Function Structure and vasculature of islets, regulation of islet secretion, Stellate Cells in health and disease The book is designed to be a reference book for pancreas researchers but its clear and readable text will appeal to teachers, students and all individuals interested in the exocrine pancreas.
Reversible Protein Acetylation
| Author | : Gregory R. Bock |
| Publisher | : John Wiley & Sons |
| Total Pages | : 310 |
| Release | : 2004-07-16 |
| Genre | : Science |
| ISBN | : 0470862629 |
A comprehensive review of recent work on chromatin and non-histone proteins, this book arises from the interactions of a multidisciplinary group of scientists involved in the study of acetylation. This area of research opens up new and exciting possibilities for drug design, and so the final chapters in the book examine some of the potential applications in the treatment of various diseases.
Plasticity in the Adult Brain: From Genes to Neurotherapy
| Author | : M.A. Hofman |
| Publisher | : Elsevier |
| Total Pages | : 497 |
| Release | : 2002-10-23 |
| Genre | : Medical |
| ISBN | : 008049773X |
In the past decade neuronal plasticity has become a major theme of modern neurobiology, from cellular and molecular mechanisms of synapse formation in worms and insects to behavioural recovery from strokes in elderly humans. For this reason the focus of interest in the present volume of Progress in Brain Research is on the topic of neuroplasticity in mature organisms, including humans. Contributions range from neurogenesis and synaptic plasticity in the adult primate brain, to neural mechanisms of learning and memory, and the influence of environmental factors and aging on the functional potential of the central nervous system. Several contributions focus on recent developments in neural regeneration and brain repair, providing challenging evidence that the use of stem cell neurotherapy may be beneficial to humans suffering from various neurological and psychiatric diseases. This volume integrates new information on the cellular and molecular mechanisms of neuroplasticity and highlights challenging future questions in this exciting and topical area of neuroscience.
Methionine Dependence of Cancer and Aging
| Author | : Robert M. Hoffman |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2019-02-07 |
| Genre | : Medical |
| ISBN | : 9781493987955 |
This book explores the methionine dependence of cancer and its effects on aging, a great story of science that is not widely known. The chapters in this book describe the discovery of methionine dependence of cancer; the molecular basis for the increased methionine demand of cancer cells and tumors; the clinical application of methionine dependence of cancer in PET imaging with [11C]methionine; the development of methioninases as cancer drugs; the anti-aging and anti-diabetes effects of methionine restriction; and the future of targeting methionine in the body for the elimination of cancer and for the extension of a healthy life-span. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Methionine Dependence of Cancer and Aging: Methods and Protocols is an important resource for researchers and scientists wishing to pursue this exciting and vital area of study."
Hazzard's Geriatric Medicine and Gerontology, Eighth Edition
| Author | : Jeffrey B. Halter |
| Publisher | : McGraw Hill Professional |
| Total Pages | : 1823 |
| Release | : 2022-06-06 |
| Genre | : Medical |
| ISBN | : 1260464466 |
The undisputed leader on the subject of geriatrics—updated to reflect the most recent advances in the field A Doody's Core Title for 2023! The leading text on the subject of geriatrics, this comprehensive guide combines gerontology principles with clinical geriatrics, offering unmatched coverage of this area of medicine. Anchored in evidence-based medicine and patient-centered practice, Hazzard's Geriatric Medicine and Gerontology presents the most up-to-date, medical information available. This updated eighth edition reflects the continued growth and increasing sophistication of geriatrics as a defined medical discipline. The book focuses on the implementation of key concepts and covers the foundation for geriatrics, as well as frequently encountered syndromes found in older adults. In addition, it provides valuable insights into the simultaneous management of multiple conditions, including psychological and social issues and their interactions, an intrinsic aspect of geriatric patient care. Features: A greater emphasize on the growing knowledge base for key topics in the field, including gerontology, geriatrics, geriatric conditions, and palliative medicine NEW chapters on: Social Determinants of Health, Health Disparities and Health Equity Age Friendly Care Geriatrics Around the World The Patient Perspective Substance Use and Disorders Applied Clinical Geroscience Managing the Care of Patients with Multiple Chronic Conditions UPDATED contributions from a respected and diverse team of geriatricians and subspecialists to reflect clinical breakthroughs and advances NEW: Extensive coverage of the COVID-19 pandemic and its impact on vulnerable older adults Updated Learning Objectives and Key Clinical Points Hundreds of full-color images
Fragile-X Syndrome
| Author | : Dalit Ben-Yosef |
| Publisher | : Humana Press |
| Total Pages | : 192 |
| Release | : 2019-03-08 |
| Genre | : Science |
| ISBN | : 9781493990795 |
This volume discusses the latest technologies used to study all aspects of Fragile-X Syndrome (FXS). The chapters in this book cover topics such as monitoring for epigenetic modifications at the FMR1 locus; modeling FXS with human pluripotent stem cells, mouse neural progenitors; mouse versus human-based models for FXS pre-clinical research; and Fragile-X associated with Tremor/Ataxia Syndrome (FXTAS). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Fragile-X Syndrome: Methods and Protocols is a valuable tool to help scientists working towards one day developing a therapeutic solution to improve the symptoms of FXS. Chapter "Induced Neurons for the Study of Neurodegenerative and Neurodevelopmental Disorders" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
The Exocrine Pancreas
| Author | : Stephen Pandol |
| Publisher | : Morgan & Claypool Publishers |
| Total Pages | : 66 |
| Release | : 2011 |
| Genre | : Medical |
| ISBN | : 1615041389 |
The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and fluid secretion, respectively, of the exocrine pancreas. This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems. Examples of pancreatic diseases resulting from dysfunction in cellular mechanisms provide emphasis of the importance of the normal physiologic mechanisms.
Stellate Cells in Health and Disease
| Author | : Chandrashekhar Gandhi |
| Publisher | : Academic Press |
| Total Pages | : 335 |
| Release | : 2015-04-10 |
| Genre | : Science |
| ISBN | : 0128005440 |
Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer. Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology. - Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy. - Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology. - Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.
