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| Author | : Jeffrey L. Benovic |
| Publisher | : |
| Total Pages | : 330 |
| Release | : 2000 |
| Genre | : Medical |
| ISBN | : |
This comprehensive text describes many techniques that are used to define the molecular mechanisms involved in receptor regulation. It covers a broad range of important concepts and methodologies in the study of G protein-coupled receptors.
| Author | : Jesús Giraldo |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 522 |
| Release | : 2011 |
| Genre | : Medical |
| ISBN | : 1849731837 |
G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. The book lies between the fields of chemical biology, molecular pharmacology, and medicinal chemistry.
| Author | : Gabriel Berstein |
| Publisher | : CRC Press |
| Total Pages | : 380 |
| Release | : 2019-04-24 |
| Genre | : Medical |
| ISBN | : 0429525265 |
Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function, knowledge of which is essential to the study of signal transduction. G Protein-Coupled Receptors has culled contributors from domestic and international sources, providing a broad base of knowledge. Some topics covered are the r
| Author | : Tatsuya Haga |
| Publisher | : CRC Press |
| Total Pages | : 336 |
| Release | : 2005-08-04 |
| Genre | : Medical |
| ISBN | : 1420038273 |
This book provides a broad base of knowledge of G-protein-coupled receptors. Useful at both the university and industrial levels, this book is of particular interest to those who are developing therapeutic approaches to diseases using drugs that influence receptor activation.
| Author | : Jürgen Wess |
| Publisher | : |
| Total Pages | : 412 |
| Release | : 1999 |
| Genre | : Cell receptors |
| ISBN | : 9780471252276 |
This is a study of the structure and function of G protein-coupled receptors (GPCRs) and provides an up-to-date presentation of methods, including molecular genetic, biochemical, and biophysical. It focuses on methodology, but also includes techniques that can be used by readers at the laboratory bench. Furthermore, each chapter provides background information and a discussion of key results.
| Author | : Lakshmi A. Devi |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 414 |
| Release | : 2008-03-01 |
| Genre | : Medical |
| ISBN | : 1592599192 |
A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as the detection of ligands for orphan GPCRs. Also discussed are the most recent developments that could lead to new drug discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.
| Author | : Marta Filizola |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2013-11-11 |
| Genre | : Science |
| ISBN | : 9789400774223 |
G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated over the years, discovering ligands of these receptors with optimal therapeutic properties is not straightforward and has certainly been hampered for years by the lack of high-resolution structural information about these receptors. Luckily, there has been a steady increase of high-resolution crystal structures of these receptors since 2007, and this information, integrated with dynamic inferences from computational and experimental methods, holds great potential for the discovery of new, improved drugs. This book, which provides, for the first time, state-of-the-art views on modeling and simulation of GPCRs, is divided into 4 parts. In the first part, the impact of currently available GPCR crystal structures on structural modeling is discussed extensively as are critical insights from simulations in the second part of the book. The third part reports recent progress in rational ligand discovery and mathematical modeling, whereas the fourth part provides an overview of bioinformatics tools and resources that are available for GPCRs.
| Author | : Sandra Siehler |
| Publisher | : Cambridge University Press |
| Total Pages | : 447 |
| Release | : 2010-09-30 |
| Genre | : Medical |
| ISBN | : 1139491741 |
Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field.
| Author | : Roland Seifert |
| Publisher | : John Wiley & Sons |
| Total Pages | : 304 |
| Release | : 2006-05-12 |
| Genre | : Science |
| ISBN | : 3527606955 |
With its particular emphasis on the constitutive activity of G-protein-coupled receptors (GPCRs)s, this book comprehensively discusses an important biological process that has not yet been covered in such depth in any other existing books on GPCRs. The international team of highly distinguished authors addresses in detail current models and concepts, to introduce medicinal chemists, physiologists, pharmacologists, and medical researchers into the advances in the understanding of GPCR activation and constitutive activity. In addition, the book provides an overview on methods of investigating constitutive GPCR activity. The text is well illustrated by selected experimental data and schemes._The chaptes are all cross-referenced with each other and cover general mechnisms, methodological approaches and cover selected important GPCR sysstems, the consequences for drug action, including, side effects, and rational drug design for GPCR targets. A highly recommended reference for researchers in academia and industry. authors addresses in detail current models and concepts, so as to introduce pharmaceutical chemists, physiologists and medical researchers to the advances in the understanding of GPCR activation and constitutive activity, and provides an overview of the methods of investigating GPCR activity. The text is backed by abundant case studies and methodological advice for analyzing GPCRs, covering selected pharmacologically relevant GPCR systems, the consequences for drug action, including unwanted side effects, and rational drug design for GPCR targets. A highly practical reference for researchers in academia and industry.
