Structure And Intrinsic Disorder In Enzymology
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| Author | : Munishwar Nath Gupta |
| Publisher | : Elsevier |
| Total Pages | : 529 |
| Release | : 2022-11-17 |
| Genre | : Science |
| ISBN | : 0323995349 |
Structure and Intrinsic Disorder in Enzymology offers a direct, yet comprehensive presentation of the fundamental concepts, characteristics and functions of intrinsically disordered enzymes, along with valuable notes and technical insights powering new research in this emerging field. Here, more than twenty international experts examine protein flexibility and cryo-enzymology, hierarchies of intrinsic disorder, methods for measurement of disorder in proteins, bioinformatics tools for predictions of structure, disorder and function, protein promiscuity, protein moonlighting, globular enzymes, intrinsic disorder and allosteric regulation, protein crowding, intrinsic disorder in post-translational, and much more. Chapters also review methods for study, as well as evolving technology to support new research across academic, industrial and pharmaceutical labs. Unifies the roles of intrinsic disorder and structure in the functioning of enzymes and proteins Examines a range of enzyme and protein characteristics, their relationship to intrinsic disorder, and methods for study Features chapter contributions from international leaders in the field
| Author | : Monika Fuxreiter |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 210 |
| Release | : 2012-03-07 |
| Genre | : Medical |
| ISBN | : 1461406595 |
Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.
| Author | : Vladimir Uversky |
| Publisher | : John Wiley & Sons |
| Total Pages | : 532 |
| Release | : 2012-02-07 |
| Genre | : Science |
| ISBN | : 0470618310 |
This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 473 |
| Release | : 2012-10-22 |
| Genre | : Science |
| ISBN | : 0123983185 |
Both strategies for investigation (computational and experimental) in structural and mechanistic Enzymology have developed to some extent independently. However, over the last few years a trend has emerged for strengthening their integration. This combination not only brings together computations and experiments focused on the same enzymatic problems, but also provides complementary insights into the investigated properties and has a powerful synergy effect. This thematic volume of Advances in Protein Chemistry and Structural Biology focuses on the recent success in structural and mechanistic enzymology and has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches. The selected contributions demonstrate how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design. Focuses on the recent success in structural and mechanistic enzymology Has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches Demonstrates how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design
| Author | : Vladimir N. Uversky |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 538 |
| Release | : 2007-05-26 |
| Genre | : Medical |
| ISBN | : 0387365346 |
The second volume continues to fill the gap in protein review and protocol literature. It does this while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders.
| Author | : Peter Tompa |
| Publisher | : CRC Press |
| Total Pages | : 362 |
| Release | : 2009-11-18 |
| Genre | : Science |
| ISBN | : 1420078933 |
The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug dev
| Author | : Munishwar Nath Gupta |
| Publisher | : CRC Press |
| Total Pages | : 223 |
| Release | : 2023-08-04 |
| Genre | : Science |
| ISBN | : 100095465X |
The book is aimed at providing an exposure to some important topics which are generally not covered adequately in formal courses in biotechnology. It informs the readers about: How micro-fluidics are proving useful in enzyme kinetics. Chemi-proteomics; combinatorial chemistry and high-throughput screening in the context of drug discovery. How enzymes can be used with gaseous substrates? How to source more robust enzymes from marine resources for diverse applications? Why some nano-materials can be chiral? Synthesis of diverse quantum dots as powerful fluorescent probes in biology. How basics of surface chemistry and immunology are vital in dealing with endemics/pandemics like Covid-19.
| Author | : Sidney A. Bernhard |
| Publisher | : |
| Total Pages | : 340 |
| Release | : 1968 |
| Genre | : Enzymes |
| ISBN | : |
| Author | : Vladimir Uversky |
| Publisher | : Academic Press |
| Total Pages | : 426 |
| Release | : 2019-09-15 |
| Genre | : |
| ISBN | : 012816851X |
"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain. Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided Includes contributions from recognized experts in the field
| Author | : Young Je Yoo |
| Publisher | : Springer |
| Total Pages | : 208 |
| Release | : 2017-01-12 |
| Genre | : Technology & Engineering |
| ISBN | : 9402410260 |
This book provides a comprehensive introduction to all aspects of enzyme engineering, from fundamental principles through to the state-of-the-art in research and industrial applications. It begins with a brief history, describing the milestones of advancement in enzyme science and technology, before going on to cover the fundamentals of enzyme chemistry, the biosynthesis of enzymes and their production. Enzyme stability and the reaction kinetics during enzymatic reactions are presented to show how enzymes function during catalysis and the factors that affect their activity. Methods to improve enzyme performance are also presented, such as cofactor regeneration and enzyme immobilization. The book emphasizes and elaborates on the performance and characteristics of enzymes at the molecular level. Finally, the book presents recent advances in enzyme engineering and some key industrial application of enzymes addressing the present needs of society. This book presents essential information not only for undergraduate and graduate students, but also for researchers in academia and industry, providing a valuable reference for the development of commercial applications of enzyme technology.
