Structural Biology For Virus Research
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| Author | : Akio Adachi |
| Publisher | : Frontiers Media SA |
| Total Pages | : 104 |
| Release | : |
| Genre | : |
| ISBN | : 2889190242 |
Viruses are absolutely and strictly dependent on target host cells for their replication. However, they have their own unique strategies at each replication step from the entry into cells, transcription, translation, assembly of viral genome/proteins, and up to the release of progeny virions from cells. We virologists have to understand these complex biological interactions between viruses and host cells. Importantly, extensive studies based on bio-structural technology have revealed in succession the detailed and bottom line mechanisms of viral replication processes otherwise impossible. We now know the highly dynamic nature of viral genome/proteins, and are impressed by their ingeniously organized functionality in hostile host environments. For characterization of viruses as a unique genetic entity and pathogenic agent, it has been critical to investigate thoroughly the individual viral components and host factors involved in the virus replication cycle. Because many viral and cellular factors essential for viral replication and pathogenicity have been newly discovered through the efforts of virologists, the necessity of contribution to the progress of virology by the structural biology is now greatly increasing. To fully understand precise mechanisms underlying the functional interaction of viral and host molecules, needless to say, it is crucially required to have their structural information. We need to know molecular details of the nucleic acids, proteins, and interacting molecules. The information indispensable for understanding certain biological phenomena may only be provided by high-resolution three-dimensional structures. Of note, a number of anti-viral drugs have been generated based on the structural information. The interacting interfaces between virus and host components, which are important for viral replication, can be potent targets for anti-viral drugs. Their structural characterization would lead to designing rigid anti-viral drugs and/or vaccines. In this Research Topic, we wish to summarize and review what the structural biology has accomplished so far to resolve the important virological issues. We also wish to describe the perspective of the structural biology for the future virology. Finally, the presentation of ongoing original works is greatly encouraged.
| Author | : Mauricio G. Mateu |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 734 |
| Release | : 2013-06-04 |
| Genre | : Medical |
| ISBN | : 9400765525 |
This book contemplates the structure, dynamics and physics of virus particles: From the moment they come into existence by self-assembly from viral components produced in the infected cell, through their extracellular stage, until they recognise and infect a new host cell and cease to exist by losing their physical integrity to start a new infectious cycle. (Bio)physical techniques used to study the structure of virus particles and components, and some applications of structure-based studies of viruses are also contemplated. This book is aimed first at M.Sc. students, Ph.D. students and postdoctoral researchers with a university degree in biology, chemistry, physics or related scientific disciplines who share an interest or are actually working on viruses. We have aimed also at providing an updated account of many important concepts, techniques, studies and applications in structural and physical virology for established scientists working on viruses, irrespective of their physical, chemical or biological background and their field of expertise. We have not attempted to provide a collection of for-experts-only reviews focused mainly on the latest research in specific topics; we have not generally assumed that the reader knows all of the jargon and all but the most recent and advanced results in each topic dealt with in this book. In short, we have attempted to write a book basic enough to be useful to M.Sc and Ph.D. students, as well as advanced and current enough to be useful to senior scientists with an interest in Structural and/or Physical Virology.
| Author | : Wah Chiu |
| Publisher | : |
| Total Pages | : 532 |
| Release | : 1997 |
| Genre | : Science |
| ISBN | : |
Historically, structural biology and virology have been separate disciplines, with the field of virology developing around particular virus families. However, recent advances in the techniques of structural biology, including high-performance computing and graphics visualization, X-ray crystallography, and electron microscopy, coupled with continued progress in molecular biology and virology have caused a major convergence of interests. "Structural virology" now provides some of the most outstanding examples of structure-function relationships in biology. Viruses encounter many common problems in their life cycles, and so the solutions that they have evolved provide instructive contrasts between different biological strategies for survival. These ideas are illustrated by each of the different chapters, most of which cover a viral system that well illustrates a particular biological function. The goal of this book is to unite the structural and biological aspects of virus function. With this in mind, each chapter has been written explicitly by experts to address a broad audience ranging from graduate students to researchers in structural biology, virology, molecular biology, and biochemistry.
| Author | : Mavis Agbandje-McKenna |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 389 |
| Release | : 2010-11-11 |
| Genre | : Medical |
| ISBN | : 184973223X |
Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development. With contributions from experts in the field of structural biology and virology this exceptional monograph will appeal to biomedical scientists involved in basic and /or applied research on viruses. It also provides up-to-date reference material for students entering the field of structural virology as well as scientists already familiar with the area.
| Author | : Michael G Rossmann |
| Publisher | : World Scientific |
| Total Pages | : 304 |
| Release | : 2021-11-10 |
| Genre | : Science |
| ISBN | : 9811246211 |
The current book attempts to give a glimpse of the scientific life of Michael Rossmann. The book begins with his very interesting and moving autobiography. His enormous energy must have been evident already from early childhood when he and his mother had to emigrate from Nazi-Germany to England, via The Netherlands. Starting school with a new language was a challenge that he managed well with the assistance of understanding teachers. Crystallography soon became the tool to explore new worlds, unknown to everybody. With a skill for mathematics, he realized that the transform of a molecular structure in the diffraction pattern could be used for analysis of both symmetry and structural relationships. This method, molecular replacement (MR, also the initials of his name) became one of his great successes of his career. The previous book by him in this series (Selected Papers by Michael G Rossmann with Commentaries) covers his main contributions in this area.With an interest in symmetry, viruses became obvious objects to study. Rossmann attacked these monstrously large molecular assemblies with his unfailing energy and his appetite for real challenges. The amazing variation of molecular arrangements with icosahedral symmetry is truly amazing. This book includes a selection of reports of the structures of some giant viruses. As always, knowing the structure enhances the understanding of function greatly, in the case of viruses the mechanism of infection is a key problem. Rossmann has contributed many central insights in this area.Thus, this book is of interest both as an interesting personal story but also for research into viruses that repeatedly plague all living organisms on the planet, right now in the form of the corona virus pandemic.
| Author | : J. Robin Harris |
| Publisher | : Springer |
| Total Pages | : 443 |
| Release | : 2018-06-13 |
| Genre | : Science |
| ISBN | : 9811084564 |
The Subcellular Biochemistry series has recently embarked upon an almost encyclopaedic coverage of topics relating to the structure and function of macromolecular complexes (Volumes 82, 83 and 87). The present multi-author text covers numerous aspects of current research into molecular virology, with emphasis upon viral protein and nucleoprotein structure and function. Structural data from cryo-electron microscopy and X-ray crystallography is displayed throughout the book. The 17 chapters in the book cover diverse interesting topics, all currently under investigation, contributed by authors who are active actively involved in present-day research. Whilst structural aspects predominate, there is much consideration of the structure-function relationship. In addition, the book correlates with and extends from Volume 68 of the series “Structure and Physics of Viruses: An Integrated Textbook”. This book is directed primarily at professionals that work in the broad field of Structural Biology and will be of particular interest to Structural Virologists. The editors, David Bhella and Robin Harris, have much experience in virology and protein structure, respectively. Dr Bhella is Director of the Scottish Macromolecular Imaging Centre. Professor Robin Harris is the long-standing Series Editor of the Subcellular Biochemistry series. He has edited and contributed to several books in the series.
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 610 |
| Release | : 2003-10-02 |
| Genre | : Science |
| ISBN | : 0080493777 |
Virus Structure covers the full spectrum of modern structural virology. Its goal is to describe the means for defining moderate to high resolution structures and the basic principles that have emerged from these studies. Among the topics covered are Hybrid Vigor, Structural Folds of Viral Proteins, Virus Particle Dynamics, Viral Gemone Organization, Enveloped Viruses and Large Viruses. Covers viral assembly using heterologous expression systems and cell extracts Discusses molecular mechanisms in bacteriophage T7 procapsid assembly, maturation and DNA containment Includes information on structural studies on antibody/virus complexes
| Author | : Phoebe Lostroh |
| Publisher | : Garland Science |
| Total Pages | : 971 |
| Release | : 2019-05-06 |
| Genre | : Science |
| ISBN | : 0429664303 |
Viruses interact with host cells in ways that uniquely reveal a great deal about general aspects of molecular and cellular structure and function. Molecular and Cellular Biology of Viruses leads students on an exploration of viruses by supporting engaging and interactive learning. All the major classes of viruses are covered, with separate chapters for their replication and expression strategies, and chapters for mechanisms such as attachment that are independent of the virus genome type. Specific cases drawn from primary literature foster student engagement. End-of-chapter questions focus on analysis and interpretation with answers being given at the back of the book. Examples come from the most-studied and medically important viruses such as HIV, influenza, and poliovirus. Plant viruses and bacteriophages are also included. There are chapters on the overall effect of viral infection on the host cell. Coverage of the immune system is focused on the interplay between host defenses and viruses, with a separate chapter on medical applications such as anti-viral drugs and vaccine development. The final chapter is on virus diversity and evolution, incorporating contemporary insights from metagenomic research. Key selling feature: Readable but rigorous coverage of the molecular and cellular biology of viruses Molecular mechanisms of all major groups, including plant viruses and bacteriophages, illustrated by example Host-pathogen interactions at the cellular and molecular level emphasized throughout Medical implications and consequences included Quality illustrations available to instructors Extensive questions and answers for each chapter
| Author | : Mauricio Comas-Garcia |
| Publisher | : Springer Nature |
| Total Pages | : 348 |
| Release | : 2023-11-01 |
| Genre | : Medical |
| ISBN | : 3031368150 |
This book highlights key findings generated during the past years from the main disciplines that constitute Physical Virology, from theoretical physics and simulations to material sciences and vaccines development to structural biology. Each chapter is written by world-class scientists from these areas and is a comprehensive review of where this field stands, as well as the future of Physical Virology. The diversity in the formal training of these scientists results in solving common problems using very distinct approaches, which can produce surprising findings. The multi- and interdisciplinary nature of this field has created a remarkable community that aims at understanding how viruses work and how they can be used in material sciences, chemistry, and biomedicine. Furthermore, the development of Physical Virology has resulted in technological advances that have shaped other fields; for example, it would be impossible to think about the development of Cryo-EM to solve the structure of complex viruses with atomic resolution without the contribution of scientists that created the field of Physical Virology. In the past decade, there has been a great success in the generation of viral systems that can encapsulate drugs, non-viral genetic material, or nanoparticles, as well as in the chemical and genetical modification of virions. Without any doubt in the immediate future, some of these technologies will jump from the bench to the market, creating a revolution in translational and biomedical sciences. The book provides key perspectives for the field, derived from expert ́s opinions.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 349 |
| Release | : 2019-09-13 |
| Genre | : Science |
| ISBN | : 0128184574 |
Complementary Strategies to Study Virus Structure and Function, Volume 104, the latest release in the Advances in Virus Research series, highlights new advances in the field, with this new volume presenting interesting chapters on X-ray structures from crystals of viral proteins grown in cellula, NMR and SAXS to study protein dynamics and natively disordered viral proteins, Mass spectrometry to study virus particle assembly, Atomic force microscopy to study virus particles, Non-enveloped viruses and interactions with antibodies, Non-enveloped viruses and their mechanism of entry into cells, Structures of enveloped virions by electron cryo-microscopy and cryo-tomography, and many other interesting topics. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Virus Research series Includes the latest information on virus structure and function
