Strategies Of Quantification
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| Author | : Kook-Hee Gil |
| Publisher | : OUP Oxford |
| Total Pages | : 337 |
| Release | : 2013-02-21 |
| Genre | : Language Arts & Disciplines |
| ISBN | : 0191643637 |
Quantification has been at the heart of research in the syntax and semantics of natural language since Aristotle. The last few decades have seen an explosion of detailed studies of the syntax and semantics of quantification and its relation to the rest of the theory of grammar, resulting in a highly sophisticated understanding of the mechanisms of quantification. This book considers the ways natural languages vary with respect to their realisation of quantificational notions. Drawing on data from English, German, Japanese, Korean, Mandarin, Hausa and others, the authors also link the variation in the expression of quantification to the notions of polarity sensitivity, free-choice and indefiniteness.
| Author | : Mizeck Chagunda |
| Publisher | : MDPI |
| Total Pages | : 168 |
| Release | : 2020-06-17 |
| Genre | : Science |
| ISBN | : 3039285300 |
Ruminants contribute significantly to human food security. However, the production of ruminants contributes to greenhouse gas (GHG) emissions that are responsible for climate change. GHGs such as methane, carbon dioxide, and nitrous oxide are produced from different processes of ruminant production. Ruminant enteric methane is a substantial component of methane produced by agriculture. This book presents novel and established methods in quantifying and reducing enteric methane emission from ruminants in different production systems. The book covers different types of ruminants including cattle, sheep, and goats. The chapters are contributed by scientists and authors from different parts of the world, demonstrating the importance of this problem and the universal drive for immediate and sustainable solutions. Although, biologically speaking, the production of enteric methane cannot be reduced to zero, high emissions are an indicator of inefficient digestion of feed in the rumen and low utilisation of feed energy. By presenting research that could lead to robust and yet practical quantification methods and mitigation strategies, this book not only contributes to the discourse and new knowledge on the magnitude of the problem but also brings forward potential solutions in different livestock production systems.
| Author | : Francois Ferre |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 379 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1461241642 |
Geneticists and molecular biologists have been interested in quantifying genes and their products for many years and for various reasons (Bishop, 1974). Early molecular methods were based on molecular hybridization, and were devised shortly after Marmur and Doty (1961) first showed that denaturation of the double helix could be reversed - that the process of molecular reassociation was exquisitely sequence dependent. Gillespie and Spiegelman (1965) developed a way of using the method to titrate the number of copies of a probe within a target sequence in which the target sequence was fixed to a membrane support prior to hybridization with the probe - typically a RNA. Thus, this was a precursor to many of the methods still in use, and indeed under development, today. Early examples of the application of these methods included the measurement of the copy numbers in gene families such as the ribosomal genes and the immunoglo bulin family. Amplification of genes in tumors and in response to drug treatment was discovered by this method. In the same period, methods were invented for estimating gene num bers based on the kinetics of the reassociation process - the so-called Cot analysis. This method, which exploits the dependence of the rate of reassociation on the concentration of the two strands, revealed the presence of repeated sequences in the DNA of higher eukaryotes (Britten and Kohne, 1968). An adaptation to RNA, Rot analysis (Melli and Bishop, 1969), was used to measure the abundance of RNAs in a mixed population.
| Author | : Social Science Research Council (U.S.). Committee on States and Social Structures |
| Publisher | : Cambridge University Press |
| Total Pages | : 406 |
| Release | : 1985-09-13 |
| Genre | : Political Science |
| ISBN | : 9780521313131 |
Papers from a conference held at Mount Kisco, N.Y., Feb. 1982, sponsored by the Committee on States and Social Structures, the Joint Committee on Latin American Studies, and the Joint Committee on Western European Studies of the Social Science Research Council. Includes bibliographies and index.
| Author | : Honghui Zhou |
| Publisher | : John Wiley & Sons |
| Total Pages | : 512 |
| Release | : 2019-03-19 |
| Genre | : Medical |
| ISBN | : 111928919X |
Thorough Overview Identifies and Addresses Critical Gaps in the Treatment of Several Chronic Diseases With increasing numbers of patients suffering from Immune-Mediated Inflammatory Diseases (IMIDs), and with the increasing reliance on biopharmaceuticals to treat them, it is imperative that researchers and medical practitioners have a thorough understanding of the absorption, distribution, metabolism and excretion (ADME) of therapeutic proteins as well as translational pharmacokinetic/pharmacodynamic (PK/PD) modeling for them. This comprehensive volume answers that need to be addressed. Featuring eighteen chapters from world-renowned experts and opinion leaders in pharmacology, translational medicine and immunology, editors Honghui Zhou and Diane Mould have curated a much-needed collection of research on the advanced applications of pharmacometrics and systems pharmacology to the development of biotherapeutics and individualized treatment strategies for the treatment of IMIDs. Authors discuss the pathophysiology of autoimmune diseases in addition to both theoretical and practical aspects of quantitative pharmacology for therapeutic proteins, current translational medicine research methodologies and novel thinking in treatment paradigm strategies for IMIDs. Other notable features include: • Contributions from well-known authors representing leading academic research centers, specialized contract research organizations and pharmaceutical industries whose pipelines include therapeutic proteins • Chapters on a wide range of topics (e.g., pathophysiology of autoimmune diseases, biomarkers in ulcerative colitis, model-based meta-analysis use in the development of therapeutic proteins) • Case studies of applying quantitative pharmacology approaches to guiding therapeutic protein drug development in IMIDs such as psoriasis, inflammatory bowel disease, multiple sclerosis and lupus Zhou and Mould’s timely contribution to the critical study of biopharmaceuticals is a valuable resource for any academic and industry researcher working in pharmacokinetics, pharmacology, biochemistry, or biotechnology as well as the many clinicians seeking the safest and most effective treatments for patients dealing with chronic immune disorders.
| Author | : Shuguang Ma |
| Publisher | : Elsevier Science |
| Total Pages | : 708 |
| Release | : 2020-07-10 |
| Genre | : Science |
| ISBN | : 0128200189 |
Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade's numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism.
| Author | : Geoff Payne |
| Publisher | : SAGE |
| Total Pages | : 201 |
| Release | : 2011-03-04 |
| Genre | : Social Science |
| ISBN | : 1446209814 |
This exciting collection is both useful and timely. It clearly lays out the problems, strategies and resources associated with the teaching of quantitative methods in modern universities. Addressing the perceived ′crisis of number′ in a practical and fresh way the book sets out dynamic new approaches to teaching quantitative methods. It offers historical, comparative, analytical reflection and empirical evidence concerning the crisis in contemporary social sciences. Experts from across the social sciences provide a wide range of authoritative insights as well as a number of useful illustrations of strategies and resources designed to help overcome this ′crisis of number′. Each chapter reflects the diversity of backgrounds and approaches within the social sciences making this an interdisciplinary, relevant addition to the subject. The book also: o focuses on innovations in how to teach quantitative research methods o reports on the latest ESRC research projects on teaching quantitative methods o locates itself within current debates about skills for employment. Clear, engaging and original this book will be essential reading for those interested in learning and teaching quantitative methods.
| Author | : Sally Engle Merry |
| Publisher | : University of Chicago Press |
| Total Pages | : 260 |
| Release | : 2016-06-10 |
| Genre | : Social Science |
| ISBN | : 022626131X |
We live in a world where seemingly everything can be measured. We rely on indicators to translate social phenomena into simple, quantified terms, which in turn can be used to guide individuals, organizations, and governments in establishing policy. Yet counting things requires finding a way to make them comparable. And in the process of translating the confusion of social life into neat categories, we inevitably strip it of context and meaning—and risk hiding or distorting as much as we reveal. With The Seductions of Quantification, leading legal anthropologist Sally Engle Merry investigates the techniques by which information is gathered and analyzed in the production of global indicators on human rights, gender violence, and sex trafficking. Although such numbers convey an aura of objective truth and scientific validity, Merry argues persuasively that measurement systems constitute a form of power by incorporating theories about social change in their design but rarely explicitly acknowledging them. For instance, the US State Department’s Trafficking in Persons Report, which ranks countries in terms of their compliance with antitrafficking activities, assumes that prosecuting traffickers as criminals is an effective corrective strategy—overlooking cultures where women and children are frequently sold by their own families. As Merry shows, indicators are indeed seductive in their promise of providing concrete knowledge about how the world works, but they are implemented most successfully when paired with context-rich qualitative accounts grounded in local knowledge.
| Author | : Harry R. Yarger |
| Publisher | : DIANE Publishing |
| Total Pages | : 93 |
| Release | : 2006 |
| Genre | : Military doctrine |
| ISBN | : 1428916229 |
| Author | : Ángel García-Alonso |
| Publisher | : John Wiley & Sons |
| Total Pages | : 432 |
| Release | : 2011-04-27 |
| Genre | : Science |
| ISBN | : 1118002075 |
The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics. This chapter shows potential applications for platelet proteomics not yet carried out. It includes examples of post-translational modifications (PTMs) analysis in platelets. The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease. This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, systems biology, and their applications to platelet-related diseases.
