Strategies Of Quantification
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| Author | : Francois Ferre |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 379 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1461241642 |
Geneticists and molecular biologists have been interested in quantifying genes and their products for many years and for various reasons (Bishop, 1974). Early molecular methods were based on molecular hybridization, and were devised shortly after Marmur and Doty (1961) first showed that denaturation of the double helix could be reversed - that the process of molecular reassociation was exquisitely sequence dependent. Gillespie and Spiegelman (1965) developed a way of using the method to titrate the number of copies of a probe within a target sequence in which the target sequence was fixed to a membrane support prior to hybridization with the probe - typically a RNA. Thus, this was a precursor to many of the methods still in use, and indeed under development, today. Early examples of the application of these methods included the measurement of the copy numbers in gene families such as the ribosomal genes and the immunoglo bulin family. Amplification of genes in tumors and in response to drug treatment was discovered by this method. In the same period, methods were invented for estimating gene num bers based on the kinetics of the reassociation process - the so-called Cot analysis. This method, which exploits the dependence of the rate of reassociation on the concentration of the two strands, revealed the presence of repeated sequences in the DNA of higher eukaryotes (Britten and Kohne, 1968). An adaptation to RNA, Rot analysis (Melli and Bishop, 1969), was used to measure the abundance of RNAs in a mixed population.
| Author | : Social Science Research Council (U.S.). Committee on States and Social Structures |
| Publisher | : Cambridge University Press |
| Total Pages | : 406 |
| Release | : 1985-09-13 |
| Genre | : Political Science |
| ISBN | : 9780521313131 |
Papers from a conference held at Mount Kisco, N.Y., Feb. 1982, sponsored by the Committee on States and Social Structures, the Joint Committee on Latin American Studies, and the Joint Committee on Western European Studies of the Social Science Research Council. Includes bibliographies and index.
| Author | : Mizeck Chagunda |
| Publisher | : MDPI |
| Total Pages | : 168 |
| Release | : 2020-06-17 |
| Genre | : Science |
| ISBN | : 3039285300 |
Ruminants contribute significantly to human food security. However, the production of ruminants contributes to greenhouse gas (GHG) emissions that are responsible for climate change. GHGs such as methane, carbon dioxide, and nitrous oxide are produced from different processes of ruminant production. Ruminant enteric methane is a substantial component of methane produced by agriculture. This book presents novel and established methods in quantifying and reducing enteric methane emission from ruminants in different production systems. The book covers different types of ruminants including cattle, sheep, and goats. The chapters are contributed by scientists and authors from different parts of the world, demonstrating the importance of this problem and the universal drive for immediate and sustainable solutions. Although, biologically speaking, the production of enteric methane cannot be reduced to zero, high emissions are an indicator of inefficient digestion of feed in the rumen and low utilisation of feed energy. By presenting research that could lead to robust and yet practical quantification methods and mitigation strategies, this book not only contributes to the discourse and new knowledge on the magnitude of the problem but also brings forward potential solutions in different livestock production systems.
| Author | : Sally Engle Merry |
| Publisher | : University of Chicago Press |
| Total Pages | : 260 |
| Release | : 2016-06-10 |
| Genre | : Social Science |
| ISBN | : 022626131X |
We live in a world where seemingly everything can be measured. We rely on indicators to translate social phenomena into simple, quantified terms, which in turn can be used to guide individuals, organizations, and governments in establishing policy. Yet counting things requires finding a way to make them comparable. And in the process of translating the confusion of social life into neat categories, we inevitably strip it of context and meaning—and risk hiding or distorting as much as we reveal. With The Seductions of Quantification, leading legal anthropologist Sally Engle Merry investigates the techniques by which information is gathered and analyzed in the production of global indicators on human rights, gender violence, and sex trafficking. Although such numbers convey an aura of objective truth and scientific validity, Merry argues persuasively that measurement systems constitute a form of power by incorporating theories about social change in their design but rarely explicitly acknowledging them. For instance, the US State Department’s Trafficking in Persons Report, which ranks countries in terms of their compliance with antitrafficking activities, assumes that prosecuting traffickers as criminals is an effective corrective strategy—overlooking cultures where women and children are frequently sold by their own families. As Merry shows, indicators are indeed seductive in their promise of providing concrete knowledge about how the world works, but they are implemented most successfully when paired with context-rich qualitative accounts grounded in local knowledge.
| Author | : Yi Tang |
| Publisher | : World Scientific |
| Total Pages | : 523 |
| Release | : 2007 |
| Genre | : Business & Economics |
| ISBN | : 9812706658 |
This book addresses selected practical applications and recent developments in the areas of quantitative financial modeling in derivatives instruments, some of which are from the authorsOCO own research and practice. While the primary scope of this book is the fixed-income market (with further focus on the interest rate market), many of the methodologies presented also apply to other financial markets, such as the credit, equity, and foreign exchange markets. This book, which assumes that the reader is familiar with the basics of stochastic calculus and derivatives modeling, is written from the point of view of financial engineers or practitioners, and, as such, it puts more emphasis on the practical applications of financial mathematics in the real market than the mathematics itself with precise (and tedious) technical conditions. It attempts to combine economic insights with mathematics and modeling so as to help the reader develop intuitions. In addition, the book addresses the counterparty credit risk modeling, pricing, and arbitraging strategies, which are relatively recent developments and are of increasing importance. It also discusses various trading structuring strategies and touches upon some popular credit/IR/FX hybrid products, such as PRDC, TARN, Snowballs, Snowbears, CCDS, credit extinguishers."
| Author | : Laurent Condamin |
| Publisher | : John Wiley & Sons |
| Total Pages | : 286 |
| Release | : 2007-01-30 |
| Genre | : Business & Economics |
| ISBN | : 0470060433 |
This book offers a practical answer for the non-mathematician to all the questions any businessman always wanted to ask about risk quantification, and never dare to ask. Enterprise-wide risk management (ERM) is a key issue for board of directors worldwide. Its proper implementation ensures transparent governance with all stakeholders’ interests integrated into the strategic equation. Furthermore, Risk quantification is the cornerstone of effective risk management,at the strategic and tactical level, covering finance as well as ethics considerations. Both downside and upside risks (threats & opportunities) must be assessed to select the most efficient risk control measures and to set up efficient risk financing mechanisms. Only thus will an optimum return on capital and a reliable protection against bankruptcy be ensured, i.e. long term sustainable development. Within the ERM framework, each individual operational entity is called upon to control its own risks, within the guidelines set up by the board of directors, whereas the risk financing strategy is developed and implemented at the corporate level to optimise the balance between threats and opportunities, systematic and non systematic risks. This book is designed to equip each board member, each executives and each field manager, with the tool box enabling them to quantify the risks within his/her jurisdiction to all the extend possible and thus make sound, rational and justifiable decisions, while recognising the limits of the exercise. Beyond traditional probability analysis, used since the 18th Century by the insurance community, it offers insight into new developments like Bayesian expert networks, Monte-Carlo simulation, etc. with practical illustrations on how to implement them within the three steps of risk management, diagnostic, treatment and audit. With a foreword by Catherine Veret and an introduction by Kevin Knight.
| Author | : Allan Matte |
| Publisher | : Elsevier |
| Total Pages | : 222 |
| Release | : 2020-08-24 |
| Genre | : Medical |
| ISBN | : 0081030193 |
Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book.
| Author | : A. Szabolcsi |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 484 |
| Release | : 2012-12-06 |
| Genre | : Philosophy |
| ISBN | : 9401158142 |
The present volume is as much a book co-authored by all the contributors as it is an edited collection of their papers. Most of the contributors have been involved in regular discussions over the past years, often inspiring the questions, or some aspects of the proposals, in each other's papers or actually collaborating on co-authored papers. ! For this reason, the contributions make related assumptions and explore highly related issues. The organization of the volume reflects this unity of aims and interests. It starts out with an overview of some of the shared formal background, and the chapters are arranged in a sequence that is intended to invite the reader to proceed from one directly to the next. Nevertheless, there has been no attempt to eliminate individual differences in either assumptions or choice of topic. All the chapters are entirely self-contained, so the reader will find it equally possible to read any of them in isolation. Two members of the UCLA community do not appear in this volume but have been an important source of inspiration for this project: Ed Keenan and Feng-hsi Liu. Many of Keenan's works have drawn attention to the empirically diverse behavior of natural language determiners and developed theoretical tools for studying them. Liu's 1990 dissertation examined the abilities of a representative sample of noun phrases to participate in scopal dependencies and branching, coming up with provocative generalizations and pointing out their significance for then-standard theories in powerful terms.
| Author | : Denis Paperno |
| Publisher | : Springer |
| Total Pages | : 1012 |
| Release | : 2017-06-30 |
| Genre | : Language Arts & Disciplines |
| ISBN | : 3319443305 |
This work presents the structure, distribution and semantic interpretation of quantificational expressions in languages from diverse language families and typological profiles. The current volume pays special attention to underrepresented languages of different status and endangerment level. Languages covered include American and Russian Sign Languages, and sixteen spoken languages from Africa, Australia, Papua, the Americas, and different parts of Asia. The articles respond to a questionnaire the editors constructed to enable detailed crosslinguistic comparison of numerous features. They offer comparable information on semantic classes of quantifiers (generalized existential, generalized universal, proportional, partitive), syntactically complex quantifiers (intensive modification, Boolean compounds, exception phrases, etc.), and several more specific issues such as quantifier scope ambiguities, floating quantifiers, and binary (type 2) quantifiers. The book is intended for semanticists, logicians interested in quantification in natural language, and general linguists as articles are meant to be descriptive and theory independent. The book continues and expands the coverage of the Handbook of Quantifiers in Natural Language (2012) by the same editors, and extends the earlier work in Matthewson (2008), Gil et al. (2013) and Bach et al (1995).
| Author | : Harry R. Yarger |
| Publisher | : DIANE Publishing |
| Total Pages | : 93 |
| Release | : 2006 |
| Genre | : Military doctrine |
| ISBN | : 1428916229 |
