Strategic Molecular Biomarkers and MicroRNAs in Cancer
| Author | : César López-Camarillo |
| Publisher | : Frontiers Media SA |
| Total Pages | : 127 |
| Release | : 2022-11-15 |
| Genre | : Medical |
| ISBN | : 2832506003 |
Strategic Molecular Biomarkers And Micrornas In Cancer
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Systems Biology of Cancer
| Author | : Sam Thiagalingam |
| Publisher | : Cambridge University Press |
| Total Pages | : 597 |
| Release | : 2015-04-09 |
| Genre | : Mathematics |
| ISBN | : 0521493390 |
An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
The origin, function and diagnostic potential of extracellular microRNA in human body fluids
| Author | : Andrey Turchinovich |
| Publisher | : Frontiers E-books |
| Total Pages | : 115 |
| Release | : 2014-07-28 |
| Genre | : Blood |
| ISBN | : 2889192423 |
Short non-coding RNA molecules, microRNAs (miRNAs), post-transcriptionally regulate gene expression in living cells. In recent years, miRNAs have been found in a wide spectrum of mammalian body fluids including blood plasma, saliva, urine, milk, seminal plasma, tears and amniotic fluid as extracellular circulating nuclease-resistant entities. The changes in miRNA spectra observed in certain fluids correlated with various pathological conditions suggesting that extracellular miRNAs can serve as informative biomarkers for certain diseases including cancer. However, the mechanism of generation and a biological role of extracellular miRNAs remain unclear. The current theories regarding extracellular miRNA origin and function suggest that these miRNAs can be either non-specific ‘by-products’ of cellular activity and cell death or specifically released cell-cell signaling messengers. The goal of this Research Topic is to bring together up-to-date knowledge about the extracellular miRNA and its role in disease diagnostics and, possibly, inter-cellular communication.
Precision Medicine in Oncology
| Author | : Bulent Aydogan |
| Publisher | : John Wiley & Sons |
| Total Pages | : 288 |
| Release | : 2020-11-02 |
| Genre | : Medical |
| ISBN | : 1119432448 |
A FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made. Topics covered include: Biologically-guided radiation therapy Informatics for precision medicine Molecular imaging Biomarkers for treatment assessment Big data Nanoplatforms Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.
MicroRNAs in Diseases and Disorders
| Author | : Philip V Peplow |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 500 |
| Release | : 2019-05-07 |
| Genre | : Science |
| ISBN | : 1788017811 |
From pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets in the treatment of these conditions. Providing a comprehensive account, this book also includes the identification of miRNAs as diagnostic and prognostic biomarkers for disease, as well as evaluates translational value from clinical trials using synthesized and functionalized miRNA mimics and inhibitors. With a global contribution list and chapters from leading experts across the field, MicroRNAs in Diseases and Disorders is an invaluable reference to miRNA researchers and health professionals in a variety of disease areas in government, academia and industry. The book will also appeal to pharmaceutical and medicinal chemists with an interest in miRNA targeting therapeutics, as well as to advanced students in chemical biology and drug discovery.
Cancer Drug Resistance
| Author | : Jose Rueff |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2016-02-25 |
| Genre | : Medical |
| ISBN | : 9781493933457 |
This volume discusses the latest advancements and technologies used in cancer drug resistance research. Cancer Drug Resistance: Overviews and Methods contains chapters that cover topics such as: studying the mechanics of resistance to DNA damaging therapeutic drugs; studies to delineate the role of efflux transporters; expression of drug transporters; resistance to targeted therapies in breast cancer; the role of microRNAs in current pancreatic cancer treatment; and cancer exosomes as mediators of drug resistance or clinical and molecular methods in drug development and the use of bioinformatics in the management of cancer drug resistance data. Written in the highly successful Methods in Molecular Biology series format, chapters include overviews of the main issues in cancer drug resistance and the respective mechanisms, as well as introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cancer Drug Resistance: Overviews and Methods, is a valuable resource to researchers, oncobiologists and clinical oncologists or anyone else who is interested in the study of cancer and its drug resistances.
MicroRNA Cancer Regulation
| Author | : Ulf Schmitz |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 352 |
| Release | : 2013-02-03 |
| Genre | : Medical |
| ISBN | : 9400755902 |
This edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and applications, together with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. We are sure that the emergence of high-throughput quantitative techniques will make this integrative approach absolutely necessary in the near future. This book will be a resource for researchers starting out with cancer microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology in cancer, and the state-of-the-art in computational microRNA biology.
MicroRNA in Cancer
| Author | : Suresh Alahari |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 149 |
| Release | : 2012-08-01 |
| Genre | : Medical |
| ISBN | : 9400746555 |
The field of microRNA biology is really emerging in the last couple of years. Several investigators highlighted the importance of miRNAs in cancer. Although there is so much literature on microRNAs exist, a comprehensive book is still not available. Thus this book will be a great use to the scientists in the field of cancer biology. In addition, this book will be a good source of information for undergraduate, graduate students who want to develop their research careers in cancer biology.
Regulation of microRNAs
| Author | : Helge Großhans |
| Publisher | : Springer |
| Total Pages | : 160 |
| Release | : 2011-08-25 |
| Genre | : Science |
| ISBN | : 9781441978240 |
Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book.
MicroRNA Technologies
| Author | : Min Jeong Kye |
| Publisher | : Humana Press |
| Total Pages | : 216 |
| Release | : 2017-07-26 |
| Genre | : Medical |
| ISBN | : 9781493971732 |
This volume examines different approaches toward understanding the function of microRNA (miRNA) and the tools used to regulate microRNA expression in nervous systems. MicroRNA Technologies also explores newly established techniques to study the role of miRNAs in the nervous system. The chapters in this book cover topics such as: high content screening for looking at the impact of overexpressed miRNAs on primary motor neurons; miRNA expression profiling by PCR array in 2D and 3D neural culture systems; analysis of cortical neuron migration using miRNA silencing; isolating and screening subcellular miRNAs in neurons; and measuring miRNA mediated translational regulation with live cell imaging. The Neuromethods series offers chapters with key advice and procedure specifics to empower the readers to successfully achieve their own scientific and experimental goals. Cutting-edge and practical, MicroRNA Technologies is a valuable resource for students and researchers who are interested about microRNAs in nervous systems.
