Hospital infection is one of the major causes of morbidity and mortality following any procedure on the human body in the hospital. Infection arises primarily because of lack of knowledge by the hospital staff about sterilization. Today, majority of super-specialty hospitals import very expensive sterilizing equipment. However, very little effort is made to train the people who run these machines. We must understand that the machine is as clever or as dumb as the person behind it. Unfortunately, in spite of so many advances in health care and so many advances in medical education, many countries do not have a single recognized training program to train sterilization technicians. This is our effort in that direction to come up with a formal training program to train technicians in this vital area of health care delivery system. This book shall benefit technologists and Central Sterile Supplies Department (CSSD) staff as well as medical students and hospital administrators to understand the intricacies and workings of a successful CSSD unit and contribute to hospital infection control in a large way.