Stem Cells in Neurodegeneration: Disease Modeling and Therapeutics
| Author | : Kim A. Staats |
| Publisher | : Frontiers Media SA |
| Total Pages | : 183 |
| Release | : 2021-08-17 |
| Genre | : Science |
| ISBN | : 288971182X |
Stem Cells In Neurodegeneration Disease Modeling And Therapeutics
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Stem Cell-based Therapy for Neurodegenerative Diseases
| Author | : Fabin Han |
| Publisher | : Springer Nature |
| Total Pages | : 144 |
| Release | : 2020-10-26 |
| Genre | : Science |
| ISBN | : 9811543704 |
This book reviews the state-of-the-art in stem-cell-based therapies for neurodegenerative diseases, and highlights advances in both animal models and clinical trials. It comprehensively discusses most neurodegenerative diseases, including such as Parkinson's, Alzheimer's and Huntington’s diseases, amyotrophic sclerosis, multiple sclerosis, muscular dystrophy and retinal degeneration, in which stem cells could potentially be used for therapy in the future. It also addresses the challenges and problems relating to the translation of stem-cell-based therapies into treatments. As such, the book will appeal to research scientists, physicians, graduate students, and medical professionals in the field of stem cells, neuroscience, neurology, neurorestoratology and major neurological disorders.
Stem Cells in Modeling Human Genetic Diseases
| Author | : Mayana Zatz |
| Publisher | : Springer |
| Total Pages | : 157 |
| Release | : 2015-08-11 |
| Genre | : Science |
| ISBN | : 3319183141 |
While most stem cell books focus on basic aspects and/or cell therapy, this book emphasizes the relevance of stem cells obtained from patients, the so-called “patients in a petri dish” as tools to investigate human genetic diseases for which there are no available effective treatment. Chapters embrace several examples of the use of iPS cell technology, a recent Nobel Prize-winning scientific breakthrough, to obtain patient-specific pluripotent cells from which many types of specialized cells involved in a particular disease can be generated, including psychiatric and neurodegenerative disorders, muscular dystrophies, laminopathies, among others. The text is a current and timely resource for postgraduate students, scientists and clinicians, interested in applications of this rapidly developing field of research in disease modeling, drug development, and emerging issues that it brings to regenerative medicine.
Stem Cells and Neurodegenerative Diseases
| Author | : Laurent Lescaudron |
| Publisher | : CRC Press |
| Total Pages | : 246 |
| Release | : 2014-03-17 |
| Genre | : Medical |
| ISBN | : 1482210738 |
This book explores the potential of stem cells for ameliorating the quality of life of patients with neurological and neurodegenerative diseases. It discusses results of pre-clinical investigations and case studies on the effects of stem cell transplantation on cell death, as well as to promote/stimulate neuroprotection after brain and spinal cord injury through trophic support, cell replacement and remyelination. The book covers the maintenance of the balance between stem cells and their progenitors within their niche, both under normal and degenerative processes and with ischemic stroke, multiple sclerosis, and brain tumor.
Applications of Stem Cells and derived Exosomes in Neurodegenerative Disorders
| Author | : Sadaf Jahan |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2023-09-09 |
| Genre | : Medical |
| ISBN | : 9789819938476 |
This book explores the therapeutic approaches of stem cells and stem cell-derived exosomes against neurodegenerative disorders (NDDs). The initial chapters introduce different neurodegenerative diseases and discuss the mechanistic aspects of their progression. The subsequent chapters cover strategies for the isolation, characterization, and differentiation of stem cells. In turn, the book reviews the protective role of stem cells against neurological disorders and examines regenerative approaches to treat neurological diseases using mesenchymal stem cells. The book also presents induced pluripotent stem cell (iPSC) technology for cellular therapy, drug screening, and in-vitro modeling of neurodegenerative diseases. Lastly, the book discusses the role of stem cells and derived exosomes as a novel therapeutic agent against Alzheimer's and Parkinson's disease and in associated signaling molecules involved in neuroprotection. This book is an invaluable source for researchers working towards understanding the potential of stem cell therapy in neurodegenerative disorders.
Neural Stem Cells In Health And Disease
| Author | : Ashok K Shetty |
| Publisher | : World Scientific Publishing Company |
| Total Pages | : 573 |
| Release | : 2015-08-28 |
| Genre | : Science |
| ISBN | : 9814623199 |
This book is a comprehensive guide on neural stem cell behavior in health and disease. The book confers the altered behavior of endogenous neural stem cells in neurodegenerative disease conditions and the prospects of neural stem cell therapy for alleviating brain dysfunction in a variety of neurodegenerative disorders.Neural stem cell activity and neurogenesis in the adult brain is now confirmed in virtually all mammalian species including humans. Hence, a series of chapters in the first half of the book discusses the current knowledge on mechanisms of neural stem cell activity, the extent and functional significance of neurogenesis in the adult brain under normal, aged and disease environments, the susceptibility of neural stem cells and the plasticity of neurogenesis to alcohol, drugs of abuse and anesthetic agents, and advanced techniques that trigger neurogenesis in non-neurogenic regions.A second series of chapters in this book are focused on discussing the promise and efficacy of grafting of neural stem cells and/or other stem cells for treating neurological disorders such as Parkinson's disease, stroke, temporal lobe epilepsy, Alzheimer's disease and spinal cord injury. The final chapter confers on advances that are made in manufacturing a variety of neural cell types from human pluripotent stem cells that can be used as donor cells for cell transplantation.
Developing stem cell-based therapies for neural repair
| Author | : Clare Parish |
| Publisher | : Frontiers Media SA |
| Total Pages | : 115 |
| Release | : 2015-01-28 |
| Genre | : Neural stem cells |
| ISBN | : 2889194027 |
Current pharmacotherapies and surgical intervention provide limited benefit in the treatment of neural injuries or halting disease progression and has resulted in significant hope for the successes of stem cell research. The properties of stem cells render them appropriate for cell replacement therapy, endogenous repair, disease modeling as well as high-throughput drug screening and development. Such applications will aide in increasing our knowledge and developing treatments for neurodegenerative disorders such as Parkinson’s disease and Huntington’s diseases as well as neural traumas including ischemic brain damage and traumatic brain injury. This Frontiers Research topic encouraged contributions from the general field of stem cell biology, with a particular emphasis on utilizing these cells to develop new therapies for neural repair. Related articles deal with issues such as: breakthroughs in stem cell proliferation/differentiation methodologies, using pluripotent and neural stem cells for transplantation and endogenous repair, the use of patient derived stem cells for disease modeling, using stem cells for drug discovery as well as the ethical issues related to the use of stem cells.
Alzheimer’s and Parkinson’s Diseases
| Author | : Israel Hanin |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 690 |
| Release | : 2013-06-29 |
| Genre | : Medical |
| ISBN | : 1475791453 |
This book represents the third in a series of International Conferences related to Alzheimer's (AD) and Parkinson's (PD) diseases. The first one took place in Eilat, Israel, in 1985; and the second one in Kyoto, Japan, in 1989. This book contains the full text of oral and poster presentations from the Third International Conference on Alzheimer's and Parkinson's Diseases: Recent Developments, held in Chicago, Illinois, U.S.A. on November 1-6, 1993. The Chicago Conference was attended by 270 participants. The Scientific Program was divided into nine oral sessions, a keynote presentation, and a poster session. The conference culminated in a Round Table Discussion involving all of the participants in the conference. The four and one-half day meeting served as an excellent medium for surveying the current status of clinical and preclinical developments in AD and PD. There were 59 oral presentations and 93 posters. This book incorporates a majority of both.
Stem Cells and Regenerative Medicine
| Author | : Philippe Taupin |
| Publisher | : Nova Publishers |
| Total Pages | : 148 |
| Release | : 2008 |
| Genre | : Medical |
| ISBN | : 9781604564747 |
Annotation. Stem Cells and Regenerative Medicine, Volumes I, II, and III, present an overview and in-depth analysis of recent developments in stem cell research and therapy in a compilation of recently-published, peer-reviewed articles.
Pluripotent Stem Cells
| Author | : Minoru Tomizawa |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 534 |
| Release | : 2016-07-20 |
| Genre | : Science |
| ISBN | : 9535124714 |
Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.
