Stem Cells And Breast Cancer
Download Stem Cells And Breast Cancer full books in PDF, epub, and Kindle. Read online free Stem Cells And Breast Cancer ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
| Author | : Maria del Mar Vivanco |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2015-06-04 |
| Genre | : Science |
| ISBN | : 9781493925186 |
The identification of normal and breast cancer stem cells has offered a new vision of this heterogeneous disease and new hopes for its prognosis and treatment. This volume provides an overview of recent developments in mammary stem cell research and discusses the many varieties of approaches used by researchers to investigate the properties and functions of mammary stem cells. The beginning chapters provide readers with an introduction to mammary stem cells, and the processes used to characterize stem cells and isolate them via fluorescent activated cell sorting. The next few chapters discuss DNA and mRNA sequencing, proteomic techniques to help profile cells, lentiviral cell transduction for gene expression, and in vivo lineage tracing. The final few chapters are dedicated to following stem cells from their initial niche to the new microenvironment at their metastasis site, and to studying these cells using physical and mathematical approaches. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Authoritative and cutting-edge, Mammary Stem Cells: Methods and Protocols aims to help members of the scientific community explore the behavior of stem cells and how to work with them in order to guide the design of new and complimentary strategies to be applied in the clinic with the ultimate end goal of fighting breast cancer.
| Author | : Anne Le |
| Publisher | : Springer |
| Total Pages | : 186 |
| Release | : 2018-06-26 |
| Genre | : Medical |
| ISBN | : 331977736X |
Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
| Author | : Helmuth Vorherr |
| Publisher | : Elsevier |
| Total Pages | : 295 |
| Release | : 2012-12-02 |
| Genre | : Science |
| ISBN | : 0323157262 |
The Breast: Morphology, Physiology, and Lactation covers the mammary morphology and function related to endocrine physiology, as well as the pathophysiologic disorders, such as galactorrhea. Knowledge of the many hormones influencing the structure and function of the breast enables one to relate cyclic endocrine ovarian changes to symptoms of premenstrual mammary tension, parenchymal alterations, and breast neoplasia. This book is divided into nine chapters and begins with a description of the female breast development. This topic is followed by a discussion on the morphological aspects of the mature female breast, including the anatomy of the mammary gland, breast changes during pregnancy, and milk synthesis. The next chapters focus on the process of lactation and the hormonal mechanisms involved in lactation maintenance. Other chapters consider the techniques, principles, and advantages of breast feeding, as well as the concept of lactation suppression. The final chapters examine the syndromes, potential causes, and management galactorrhea, which is associated with increased pituitary prolactin secretion and deficient gonadotropin production. This book is of value to medical students, physiologists, endocrinologists, pharmacologists, basic and clinical investigators, physicians, and clinicians.
| Author | : Phuc Van Pham |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 570 |
| Release | : 2017-04-05 |
| Genre | : Medical |
| ISBN | : 9535129996 |
Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.
| Author | : Surajit Pathak |
| Publisher | : Springer Nature |
| Total Pages | : 369 |
| Release | : 2020-10-17 |
| Genre | : Medical |
| ISBN | : 9811551200 |
This book discusses the recent developments in the therapeutic implications of cancer stem cells for the effective diagnosis, prognosis, and treatment of cancer. It summarizes the various stem cells of common cancers including colon, pancreas, lungs, prostate, melanoma, and glioblastoma, and reviews the potential role of cancer stem cells in tissue aggressiveness, examining the functional contribution of cancer stem cells in the establishment and recurrence of cancerous tumors. Further, it explores the potential of cancer stem cells as novel therapeutic targets for the treatment and prevention of tumor progression. The book also discusses the various approaches for detecting, isolating, and characterizing different cancer stem cells and signaling pathways that control their replication, survival, and differentiation. Lastly, it explores the key features and mechanisms of drug resistance, chemo-resistance, and radio-resistance in cancer stem cells to improve therapeutic rationale.
| Author | : Dong-Young Noh |
| Publisher | : Springer Nature |
| Total Pages | : 630 |
| Release | : 2021-05-13 |
| Genre | : Medical |
| ISBN | : 9813296208 |
This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.
| Author | : Tarik Regad |
| Publisher | : John Wiley & Sons |
| Total Pages | : 378 |
| Release | : 2015-05-06 |
| Genre | : Science |
| ISBN | : 1118670620 |
Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics Tarik Regad, The John van Geest Cancer Research Centre, Nottingham Trent University, UK, Thomas J. Sayers, Centre for Cancer Research, National Cancer Institute, Frederick, USA and Robert Rees The John van Geest Cancer Research Centre, Nottingham Trent University, UK The field of cancer stem cells is expanding rapidly, with many groups focusing on isolating and identifying cancer stem cell populations. Although some progress has been made developing efficient cancer therapies, targeting cancer stem cells remains one of the important challenges facing the growing stem cell research community. Principles of Stem Cell Biology and Cancer brings together original contributions from international experts in the field to present the very latest information linking stem cell biology and cancer. Divided into two parts, the book begins with a detailed introduction to stem cell biology with a focus on the characterization of these cells, progress that has been made in their identification, as well as future therapeutic applications of stem cells. The second part focuses on cancer stem cells and their role in cancer development, progression and chemo-resistance. This section of the book includes an overview of recent progress concerning therapies targeting cancer stem cells. Features: An authoritative introduction to the link between stem cell biology and cancer. Includes contributions from leading international experts in the field. Well-illustrated with full colour figures throughout. This book will prove an invaluable resource for basic and applied researchers and clinicians working on the development of new cancer treatments and therapies, providing a timely publication of high quality reviews outlining the current progress and exciting future possibilities for stem cell research.
| Author | : Phuc Van Pham |
| Publisher | : |
| Total Pages | : |
| Release | : 2015 |
| Genre | : |
| ISBN | : 9783319220215 |
This volume thoroughly examines breast cancer stem cells (BCSCs), from basic definitions to techniques for identifying, isolating, culturing, and targeting BCSCs for therapy; there is additional focus on pre-clinical and clinical results. The text begins with a discussion of breast cancer, focusing especially on the limitations of current therapies in its treatment. The subsequent chapters introduce and compare stem cells and cancer stem cells, describe properties and isolation techniques of BCSCs, and examine BCSC-targeting approaches. The text concludes with a discussion of controversy surrounding the BCSC hypothesis and of future research directions. Breast Cancer Stem Cells & Therapy Resistance, part of the SpringerBriefs in Stem Cells series, provides a succinct yet comprehensive overview of BCSCs for advanced students, graduate students and researchers as well as those working with breast cancer or stem cells in a clinical setting.
| Author | : Rebecca G. Bagley |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 765 |
| Release | : 2010-09-02 |
| Genre | : Medical |
| ISBN | : 1441966153 |
The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include vascular endothelial cells and pe- cytes, as well as inflammatory cells such as neutrophils, monocytes, macrophages, mast cells and eosinophils, and lymphocytes. The tumor cells also interact with stromal cells and with elements of the tissue extracellular matrix. What has been less appreciated is the role that these cells could have in modulating the growth, invasion, and metastasis of the tumor. Early on, the elements of what we now call the tumor microenvironment were considered to be more or less innocent bysta- ers to the role of the tumor cells as they grew and invaded local sites. Today, there is an increased understanding of the critical role of the tumor microenvironment as dramatically influencing the course of tumor development and dissemination. This volume represents a superb compilation of the latest thoughts and data regarding the role of each essential component of the tumor microenvironment in cancer development and progression. Perhaps, the earliest recognition of the role of nonmalignant cells as cancer re- lators was the recognition that lymphocytes can participate in what was termed “immune surveillance” in the 1960s. Our understanding of tumor immunity has improved markedly since then, and there are now successful clinical studies sh- ing the potential use of immune-based therapies in cancer treatment.
| Author | : Jamie A. Goode |
| Publisher | : John Wiley & Sons |
| Total Pages | : 322 |
| Release | : 2001-11-28 |
| Genre | : Science |
| ISBN | : 9780471499596 |
Several fundamentally important questions form the basis for this book. What are the relationships between tumour formation and tumour pH? What are the effects of tumour pH and hypoxia on carcinogenesis or tumorigenesis? What are the therapeutic consequences of tumour pH? It is hypothesised that low extracellular pH is not only an important consequence of tumour growth but may also promote further tumorigenic transformation. Furthermore, in vitro studies suggest that low pH strongly affects the efficacy of chemo- and radiotherapy. Better understanding of the influence of pH on tumour growth, coupled with manipulation of the pH of the tumour microenvironment, may lead to the development of more effective therapies.
