Statistical Physics Of Dna
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Author | : Nikos Theodorakopoulos |
Publisher | : World Scientific |
Total Pages | : 196 |
Release | : 2019-12-24 |
Genre | : Science |
ISBN | : 9811209553 |
The stability of the DNA double helix is contingent on fine-tuning a number of physicochemical control parameters. Varying any one of them leads to separation of the two strands, in what constitutes a rare physical example of a thermodynamic phase transition in a one-dimensional system. The present book aims at providing a self-contained account of the statistical physics of cooperative processes in DNA, e.g. thermal and mechanical dissociation, force-induced melting, equilibria of hairpin-like secondary structures. In addition, the book presents some fundamental aspects of DNA elasticity, as observed in key experiments, old and new. The latter include some recently published scattering data on apparently soft, short DNA chains and their interpretation in terms of local structural defects (permanent bends, 'kinky DNA', after the original Crick-Klug hypothesis).The development of mathematical models used (Kratky-Porod polymer chain, Poland-Scheraga and Peyrard-Bishop-Dauxois models of DNA melting) emphasizes the use of realistic parameters and the relevance of practical numerical methods for comparing with experimental data. Accordingly, a large number of specially produced figures has been included.The presentation is at the level of an advanced undergraduate or introductory graduate course. An extra chapter provides the necessary mathematical background on elasticity of model polymer chains.
Author | : |
Publisher | : |
Total Pages | : 20 |
Release | : 2015 |
Genre | : |
ISBN | : 9789176233153 |
Author | : Ivo Grosse |
Publisher | : |
Total Pages | : 710 |
Release | : 2000 |
Genre | : DNA |
ISBN | : |
Author | : |
Publisher | : Amer Inst of Physics |
Total Pages | : 350 |
Release | : 1994 |
Genre | : Science |
ISBN | : 1563960710 |
This text presents an introduction to the field of statistical physics of macromolecules, from the basic concepts to modern achievements. Applications in various fields of polymer physical chemistry and molecular biophysics are also covered, as are: the fundamentals of statistical theory of polymer solutions and melts; classical, sealing and renormalization group approaches; the main ideas of statistical theories of polymer liquid crystals, polymer networks and polyelectrolytes; dynamic viscoelastic behavior of polymer systems; models of house, Zimm and reptation concepts; and specific features of main biopolymers - DNA and proteins. This English edition also includes sections describing the most important recent advances such as: statistical theory of DNA gel-electrophoresis, polymers at interfaces, and dynamics of concentrated solutions of rigid polymers.
Author | : Stanislaw Cebrat |
Publisher | : |
Total Pages | : |
Release | : 1999 |
Genre | : |
ISBN | : |
Author | : A. Gadomski |
Publisher | : North Holland |
Total Pages | : 0 |
Release | : 2000-01-19 |
Genre | : Science |
ISBN | : 9780444504098 |
The field of statistical physics has undergone a spectacular development in recent years. The fundamentals of the subject have advanced dynamically with multidisciplinary approaches involving physicists, chemists and mathematicians. Equally spectacular has been the development of applications of statistical mechanics to shed light on a wide range of problems, many of them arising in fields quite distant from traditional physics disciplines. Recent applications range from such topics as oil recovery from porous rock to protein folding, DNA structure, morphogenesis and the cooperative behavior of living creatures. Concepts and methods of statistical physics have been applied successfully to "exotic" problems that seem to be far from physics, such as vehicular and pedestrial traffic, or economy and finance. This book presents not only the keynote invited talks, but a number of high quality, interesting, contributed communications from senior scientists and young students active in the field. Topics covered include DNA migration, wetting, chemical waves, granular media, molecular motors, biological pattern formation and motion, as well as practical problems such as heart diagnosis, internet traffic jamming, oil recovery and econophysics.
Author | : Kerson Huang |
Publisher | : World Scientific |
Total Pages | : 159 |
Release | : 2005-05-30 |
Genre | : Science |
ISBN | : 9814481068 |
This book introduces an approach to protein folding from the point of view of kinetic theory. There is an abundance of data on protein folding, but few proposals are available on the mechanism driving the process. Here, presented for the first time, are suggestions on possible research directions, as developed by the author in collaboration with C C Lin.The first half of this invaluable book contains a concise but relatively complete review of relevant topics in statistical mechanics and kinetic theory. It includes standard topics such as thermodynamics, the Maxwell-Boltzmann distribution, and ensemble theory. Special discussions include the dynamics of phase transitions, and Brownian motion as an illustration of stochastic processes.The second half develops topics in molecular biology and protein structure, with a view to discovering mechanisms underlying protein folding. Attention is focused on the energy flow through the protein in its folded state. A mathematical model, based on the Brownian motion of coupled harmonic oscillators, is worked out in the appendix.
Author | : Denis Wirtz |
Publisher | : |
Total Pages | : 360 |
Release | : 1997 |
Genre | : Science |
ISBN | : |
Since statistical physics is a tool for the study not only of disordered physical systems, but of biological systems as well, this book from MRS focuses on both. While including physical problems such as fractals, pattern formation at first-order phase transitions, and glassy dynamics, the book also focuses on problems such as the statistical mechanics of DNA and DNA replications, structuring in biological systems, and problems in 'biologically inspired physics'. Topics include: statistical mechanics of proteins; statistical mechanics of DNA; biologically inspired physics; statistical mechanics in biology; micromanipulation in physics and biology; friction and fracture; statistical mechanics in physics and granular media.
Author | : Stanisław Cebrat |
Publisher | : |
Total Pages | : 216 |
Release | : 1999 |
Genre | : |
ISBN | : |
Author | : Earl Prohofsky |
Publisher | : Cambridge University Press |
Total Pages | : 241 |
Release | : 1995-07-28 |
Genre | : Science |
ISBN | : 0521451841 |
This book develops a statistical, mechanical analysis of the stability of macromolecules when melting.