Statistical Methods And Reasoning For The Clinical Sciences
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| Author | : Thomas D. Cook |
| Publisher | : CRC Press |
| Total Pages | : 465 |
| Release | : 2007-11-19 |
| Genre | : Mathematics |
| ISBN | : 1584880279 |
Clinical trials have become essential research tools for evaluating the benefits and risks of new interventions for the treatment and prevention of diseases, from cardiovascular disease to cancer to AIDS. Based on the authors’ collective experiences in this field, Introduction to Statistical Methods for Clinical Trials presents various statistical topics relevant to the design, monitoring, and analysis of a clinical trial. After reviewing the history, ethics, protocol, and regulatory issues of clinical trials, the book provides guidelines for formulating primary and secondary questions and translating clinical questions into statistical ones. It examines designs used in clinical trials, presents methods for determining sample size, and introduces constrained randomization procedures. The authors also discuss how various types of data must be collected to answer key questions in a trial. In addition, they explore common analysis methods, describe statistical methods that determine what an emerging trend represents, and present issues that arise in the analysis of data. The book concludes with suggestions for reporting trial results that are consistent with universal guidelines recommended by medical journals. Developed from a course taught at the University of Wisconsin for the past 25 years, this textbook provides a solid understanding of the statistical approaches used in the design, conduct, and analysis of clinical trials.
| Author | : Eiki Satake |
| Publisher | : Plural Publishing |
| Total Pages | : 593 |
| Release | : 2014-08-01 |
| Genre | : Medical |
| ISBN | : 1597566578 |
| Author | : Glenn Walker |
| Publisher | : SAS Institute |
| Total Pages | : 553 |
| Release | : 2010-02-15 |
| Genre | : Mathematics |
| ISBN | : 1607644258 |
Glenn Walker and Jack Shostak's Common Statistical Methods for Clinical Research with SAS Examples, Third Edition, is a thoroughly updated edition of the popular introductory statistics book for clinical researchers. This new edition has been extensively updated to include the use of ODS graphics in numerous examples as well as a new emphasis on PROC MIXED. Straightforward and easy to use as either a text or a reference, the book is full of practical examples from clinical research to illustrate both statistical and SAS methodology. Each example is worked out completely, step by step, from the raw data. Common Statistical Methods for Clinical Research with SAS Examples, Third Edition, is an applications book with minimal theory. Each section begins with an overview helpful to nonstatisticians and then drills down into details that will be valuable to statistical analysts and programmers. Further details, as well as bonus information and a guide to further reading, are presented in the extensive appendices. This text is a one-source guide for statisticians that documents the use of the tests used most often in clinical research, with assumptions, details, and some tricks--all in one place. This book is part of the SAS Press program.
| Author | : Charan Singh Rayat |
| Publisher | : Springer |
| Total Pages | : 165 |
| Release | : 2018-08-23 |
| Genre | : Medical |
| ISBN | : 9811308276 |
This book covers all aspects of statistical methods in detail with applications. It presents solutions to the needs of post-graduate medical students, doctors and basic medical scientists for statistical evaluation of data. In present era, dependency on softwares for statistical analysis is eroding the basic understanding of the statistical methods and their applications. As a result, there are very few basic medical scientists capable of analyzing their research data due to lack of knowledge and ability. This book has been written in systematic way supported by figures and tables for basic understanding of various terms, definitions, formulae and applications of statistical methods with solved examples and graphic presentation of data to create interest in this mathematical science.
| Author | : J. Philip Miller |
| Publisher | : Elsevier |
| Total Pages | : 363 |
| Release | : 2010-11-08 |
| Genre | : Mathematics |
| ISBN | : 0444537384 |
Essential Statistical Methods for Medical Statistics presents only key contributions which have been selected from the volume in the Handbook of Statistics: Medical Statistics, Volume 27 (2009). While the use of statistics in these fields has a long and rich history, the explosive growth of science in general, and of clinical and epidemiological sciences in particular, has led to the development of new methods and innovative adaptations of standard methods. This volume is appropriately focused for individuals working in these fields. Contributors are internationally renowned experts in their respective areas. - Contributors are internationally renowned experts in their respective areas - Addresses emerging statistical challenges in epidemiological, biomedical, and pharmaceutical research - Methods for assessing Biomarkers, analysis of competing risks - Clinical trials including sequential and group sequential, crossover designs, cluster randomized, and adaptive designs - Structural equations modelling and longitudinal data analysis
| Author | : Basavarajaiah D. M. |
| Publisher | : Springer Nature |
| Total Pages | : 380 |
| Release | : 2020-11-05 |
| Genre | : Medical |
| ISBN | : 9811582106 |
Recent Statistical techniques are one of the basal evidence for clinical research, a pivotal in handling new clinical research and in evaluating and applying prior research. This book explores various choices of statistical tools and mechanisms, analyses of the associations among different clinical attributes. It uses advanced statistical methods to describe real clinical data sets, when the clinical processes being examined are still in the process. This book also discusses distinct methods for building predictive and probability distribution models in clinical situations and ways to assess the stability of these models and other quantitative conclusions drawn by realistic experimental data sets. Design of experiments and recent posthoc tests have been used in comparing treatment effects and precision of the experimentation. This book also facilitates clinicians towards understanding statistics and enabling them to follow and evaluate the real empirical studies (formulation of randomized control trial) that pledge insight evidence base for clinical practices. This book will be a useful resource for clinicians, postgraduates scholars in medicines, clinical research beginners and academicians to nurture high-level statistical tools with extensive scope.
| Author | : Lauren K. Nelson |
| Publisher | : Plural Publishing |
| Total Pages | : 294 |
| Release | : 2020-08-26 |
| Genre | : Medical |
| ISBN | : 163550211X |
Research in Communication Sciences and Disorders: Methods for Systematic Inquiry, Fourth Edition is a comprehensive yet comprehendible text meant for instructors and students of research methods in the field of communication sciences and disorders. This forward-thinking book reflects the movement toward evidence-based practice in speech-language pathology and audiology. The authors ensure that the concepts associated with evidence-based practice are integrated throughout the chapters. Rather than treating empirical research and searching for clinical evidence as separate topics, this text presents both as different applications of a process of scientific inquiry. The order of the chapters reflects the steps a researcher or clinician might complete when conducting an investigation. Also included are features that help students be more active in learning the material. Each chapter has a set of review questions or case scenarios that can be used as homework, as probe questions in class, or as a basis for group activities. In addition, the authors provide lists of supplemental readings from the research literature in the field. New to the Fourth Edition: * New author: Jaimie L. Gilbert for an enhanced audiology perspective * New chapter: Writing a Literature Review * Reorganized for better flow of information * Various new and updated references to reflect the current state of research * Additional illustrations and tables * Expanded material on critical appraisal Disclaimer: Please note that ancillary content (such as documents, audio, and video, etc.) may not be included as published in the original print version of this book.
| Author | : Frederick W. Faltin |
| Publisher | : John Wiley & Sons |
| Total Pages | : 533 |
| Release | : 2012-07-24 |
| Genre | : Medical |
| ISBN | : 1119942047 |
Statistical Methods in Healthcare In recent years the number of innovative medicinal products and devices submitted and approved by regulatory bodies has declined dramatically. The medical product development process is no longer able to keep pace with increasing technologies, science and innovations and the goal is to develop new scientific and technical tools and to make product development processes more efficient and effective. Statistical Methods in Healthcare focuses on the application of statistical methodologies to evaluate promising alternatives and to optimize the performance and demonstrate the effectiveness of those that warrant pursuit is critical to success. Statistical methods used in planning, delivering and monitoring health care, as well as selected statistical aspects of the development and/or production of pharmaceuticals and medical devices are also addressed. With a focus on finding solutions to these challenges, this book: Provides a comprehensive, in-depth treatment of statistical methods in healthcare, along with a reference source for practitioners and specialists in health care and drug development. Offers a broad coverage of standards and established methods through leading edge techniques. Uses an integrated case study based approach, with focus on applications. Looks at the use of analytical and monitoring schemes to evaluate therapeutic performance. Features the application of modern quality management systems to clinical practice, and to pharmaceutical development and production processes. Addresses the use of modern statistical methods such as Adaptive Design, Seamless Design, Data Mining, Bayesian networks and Bootstrapping that can be applied to support the challenging new vision. Practitioners in healthcare-related professions, ranging from clinical trials to care delivery to medical device design, as well as statistical researchers in the field, will benefit from this book.
| Author | : P. Nagarajan |
| Publisher | : Springer Nature |
| Total Pages | : 797 |
| Release | : 2021-07-23 |
| Genre | : Science |
| ISBN | : 981160987X |
This book comprehensively reviews the anatomy, physiology, genetics and pathology of laboratory animals as well as the principles and practices of using laboratory animals for biomedical research.It covers the design of buildings used for laboratory animals, quality control of laboratory animals, and toxicology, and discusses various animal models used for human diseases. It also highlights aspects, such as handling and restraint and administration of drugs, as well as breeding and feeding of laboratory animals, and provides guidelines for developing meaningful experiments using laboratory animals.Further, the book discusses various alternatives to animal experiments for drug and chemical testing, including their advantages over the current approaches. Lastly, it examines the potential effect of harmful pathogens on the physiology of laboratory animals and discusses the state of art in in vivo imaging techniques.The book is a useful resource for research scientists, laboratory animal veterinarians, and students of laboratory animal medicine.
| Author | : Ying Lu |
| Publisher | : World Scientific |
| Total Pages | : 1471 |
| Release | : 2015-06-29 |
| Genre | : Medical |
| ISBN | : 9814583324 |
The book aims to provide both comprehensive reviews of the classical methods and an introduction to new developments in medical statistics. The topics range from meta analysis, clinical trial design, causal inference, personalized medicine to machine learning and next generation sequence analysis. Since the publication of the first edition, there have been tremendous advances in biostatistics and bioinformatics. The new edition tries to cover as many important emerging areas and reflect as much progress as possible. Many distinguished scholars, who greatly advanced their research areas in statistical methodology as well as practical applications, also have revised several chapters with relevant updates and written new ones from scratch.The new edition has been divided into four sections, including, Statistical Methods in Medicine and Epidemiology, Statistical Methods in Clinical Trials, Statistical Genetics, and General Methods. To reflect the rise of modern statistical genetics as one of the most fertile research areas since the publication of the first edition, the brand new section on Statistical Genetics includes entirely new chapters reflecting the state of the art in the field.Although tightly related, all the book chapters are self-contained and can be read independently. The book chapters intend to provide a convenient launch pad for readers interested in learning a specific topic, applying the related statistical methods in their scientific research and seeking the newest references for in-depth research.
