Creep and Creep-rupture Behavior of Wood-based Structural Panels

Creep and Creep-rupture Behavior of Wood-based Structural Panels
Author: Theodore Laufenberg
Publisher:
Total Pages: 24
Release: 1999
Genre: Paneling
ISBN:

This paper summarizes a cooperative research program between the USDA Forest Service, Forest Products Laboratory (FPL), in Madison, Wisconsin, and Forintek Canada Corp. in Vancouver, British Columbia, Canada. This research program provided detailed creep--rupture and some creep information for composite panel products. Commercially produced plywood, oriented strandboard (OSB), and minimally aligned waferboard were tested to identify nine mills (three for each product) that produced panels with a range of flexural creep performance. The three plywood, three OSB, and three waferboard products (nine products total, one from each mill) were then tested to provide information on their duration of load (DOL) and creep performance. Large panel specimens were subjected to both rampload and constant-load tests under one environmental condition. The constant-load results provided conventional or deterministic DOL factors that compared favorably with National Design Specifications recommended for adjusting lumber design strength properties under dry service conditions. Ramp-load specimen data generally indicated a lower rate of damage accumulation than did data for constant-load specimens. Creep tests at two low constant-load levels were also performed on large specimens under three environmental conditions for a 6-month period. Those results suggested that present deterministic creep factors in panel design practice might be acceptable for plywood under the influence of relatively severe conditions, for OSB in moderate conditions, and for waferboard in dry service environmental conditions.

Clinical and Statistical Considerations in Personalized Medicine

Clinical and Statistical Considerations in Personalized Medicine
Author: Claudio Carini
Publisher: CRC Press
Total Pages: 368
Release: 2014-03-27
Genre: Mathematics
ISBN: 1466593873

Clinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development. Robust Biomarkers for Drug Development and Disease Treatment The first four chapters discuss biomarker development from a clinical perspective. Coverage ranges from an introduction to biomarkers to advances in RNAi screens, epigenetics, and rare diseases as targets for personalized medicine approaches. Subsequent chapters examine the statistical considerations in applying a personalized medicine approach, including multiplicity in pharmacogenomics. The last chapter assesses the regulatory issues involved in using biomarkers. Improve Patient Care and Reduce Costs and Side Effects Despite the vast amount of literature on biomarkers, there is no comprehensive book that integrates the clinical and statistical components. This book is one of the first to incorporate both the clinical and statistical aspects of biomarkers in the personalized medicine paradigm. Covering a wide spectrum of personalized medicine-related topics, it presents state-of-the-art techniques for advancing the application of biomarkers in drug discovery and development.

Scientific and Technical Aerospace Reports

Scientific and Technical Aerospace Reports
Author:
Publisher:
Total Pages: 1390
Release: 1987
Genre: Aeronautics
ISBN:

Lists citations with abstracts for aerospace related reports obtained from world wide sources and announces documents that have recently been entered into the NASA Scientific and Technical Information Database.