Neutrosophy as science has inclusive attributes that make possible to extract the contributions of neutral values in the analysis of data sets; it builds a unified field of logic for transdisciplinary studies that transcend the boundaries between natural and social sciences. Neutral philosophy seeks to solve the problems of indeterminacy that appear universally, to reform the current natural or social sciences, with an open methodology to promote innovation. The research products related in this special issue start from the premise that the difficulty is not the complexity of the social environment, but the instrumental obsolescence to observe, interpret and manage that complexity, there are bold approaches and proposals for valid solutions that come to enrich the universe of resolution through the use of neutral methods. In the last year, the use of tools related to neutrosophy and its application to the social sciences, modeling of social phenomena based on simulation agents, problems associated with health, psychology, education, environmental management and sustainability solutions and legal sciences has increased in the events organized by the Asociacion Latinoamericana de Ciencias Neutrosoficas (ALCN in Spanish). The methods of higher incidence are cognitive maps, neutral Iadovs, neutral Delphi, analytical hierarchy process methods, neutral statistics, neutral personality models, among the most significant. In this special issue, there is a predominance of research from Ecuadorian universities, demonstrating how neutrosophy and its methods are consolidated as instruments of analysis, inference and research validation.