Single Biomolecule Detection And Analysis
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| Author | : Tuhin Subhra Santra |
| Publisher | : CRC Press |
| Total Pages | : 355 |
| Release | : 2023-08-15 |
| Genre | : Technology & Engineering |
| ISBN | : 1000916650 |
This collection discusses various micro/nanodevice design and fabrication for single-biomolecules detection. It will be an ideal reference text for graduate students and professionals in diverse subject areas including materials science, biomedical engineering, chemical engineering, mechanical engineering, and nanoscience. This book- Discusses techniques of single-biomolecule detection, their advantages, limitations, and applications. Covers comprehensively several electrochemical detection techniques. Provides single-molecule separation, sensing, imaging, sequencing, and analysis in detail. Examines different types of cantilever-based biomolecule sensing, and its limitations. Single Biomolecule Detection and Analysis covers single-biomolecule detection and characterization using micro/nanotechnologies and micro/nanofluidic devices, electrical and magnetic detection technologies, microscopy and spectroscopy techniques, single biomolecule optical, and nanopore devices. The text covers key important biosensors-based detection, stochastic optical reconstruction microscopy-based detection, electrochemical detection, metabolic engineering of animal cells, single-molecule intracellular delivery and tracking, terahertz spectroscopy-based detection, total internal reflection fluorescence (TIFR) detection, and Fluorescence Correlation Spectroscopy (FCS) detection. The text will be useful for graduate students and professionals in diverse subject areas including materials science, biomedical engineering, chemical engineering, mechanical engineering, and nanoscience. Discussing chemical process, physical process, separation, sensing, imaging, sequencing, and analysis of single-molecule detection, this text will be useful for graduate students and professionals in diverse subject areas including materials science, biomedical engineering, chemical engineering, mechanical engineering, and nanoscience. It covers microscopy and spectroscopy techniques for single-biomolecule detection, analysis, and their biomedical engineering applications.
| Author | : Tuhin Subhra Santra |
| Publisher | : MDPI |
| Total Pages | : 254 |
| Release | : 2021-06-02 |
| Genre | : Science |
| ISBN | : 3036506284 |
Cells are the most fundamental building block of all living organisms. The investigation of any type of disease mechanism and its progression still remains challenging due to cellular heterogeneity characteristics and physiological state of cells in a given population. The bulk measurement of millions of cells together can provide some general information on cells, but it cannot evolve the cellular heterogeneity and molecular dynamics in a certain cell population. Compared to this bulk or the average measurement of a large number of cells together, single-cell analysis can provide detailed information on each cell, which could assist in developing an understanding of the specific biological context of cells, such as tumor progression or issues around stem cells. Single-cell omics can provide valuable information about functional mutation and a copy number of variations of cells. Information from single-cell investigations can help to produce a better understanding of intracellular interactions and environmental responses of cellular organelles, which can be beneficial for therapeutics development and diagnostics purposes. This Special Issue is inviting articles related to single-cell analysis and its advantages, limitations, and future prospects regarding health benefits.
| Author | : Jeong-Yeol Yoon |
| Publisher | : Elsevier |
| Total Pages | : 409 |
| Release | : 2024-07-07 |
| Genre | : Science |
| ISBN | : 044322000X |
Machine learning (ML) has recently become popular in chemical and biological sensing applications. ML is a subset of artificial intelligence (AI) and other AI techniques have been used in various chemical and biological sensing. Machine Learning and Artificial Intelligence in Chemical and Biological Sensing covers the theoretical background and practical applications of various ML/AI methods toward chemical and biological sensing. No comprehensive reference text has been available previously to cover the wide breadth of this topic. The Editors have written the first three chapters to firmly introduce the reader to fundamental ML theories that can be used for chemical/biosensing. The subsequent chapters then cover the practical applications with contributions by various experts in the field. They show how ML and AI-based techniques can provide solutions for: 1) identifying and quantifying target molecules when specific receptors are unavailable 2) analyzing complex mixtures of target molecules, such as gut microbiome and soil microbiome 3) analyzing high-throughput and high-dimensional data, such as drug screening, molecular interaction, and environmental toxicant analysis, 4) analyzing complex data sets where fingerprinting approach is needed This book is written primarily for upper undergraduate students, graduate students, research staff, and faculty members at teaching and research universities and colleges who are working on chemical sensing, biosensing, analytical chemistry, analytical biochemistry, biomedical imaging, medical diagnostics, environmental monitoring, and agricultural applications. - Presents the first comprehensive reference text on the use of ML and AI for chemical and biological sensing - Provides a firm grounding in the fundamental theories on ML and AI before covering the practical applications with contributions by various experts in the field - Includes a wide array of practical applications covered, including: E-nose, Raman, SERS, lens-free imaging, multi/hyperspectral imaging, NIR/optical imaging, receptor-free biosensing, paper microfluidics, single molecule analysis in biomedicine, in situ protein characterization, microbial population dynamics, and all-in-one sensor systems
| Author | : Peter Jomo Walla |
| Publisher | : John Wiley & Sons |
| Total Pages | : 358 |
| Release | : 2015-09-10 |
| Genre | : Science |
| ISBN | : 3527683550 |
This updated and up-to-date version of the first edition continues with the really interesting stuff to spice up a standard biophysics and biophysical chemistry course. All relevant methods used in current cutting edge research including such recent developments as super-resolution microscopy and next-generation DNA sequencing techniques, as well as industrial applications, are explained. The text has been developed from a graduate course taught by the author for several years, and by presenting a mix of basic theory and real-life examples, he closes the gap between theory and experiment. The first part, on basic biophysical chemistry, surveys fundamental and spectroscopic techniques as well as biomolecular properties that represent the modern standard and are also the basis for the more sophisticated technologies discussed later in the book. The second part covers the latest bioanalytical techniques such as the mentioned super-resolution and next generation sequencing methods, confocal fluorescence microscopy, light sheet microscopy, two-photon microscopy and ultrafast spectroscopy, single molecule optical, electrical and force measurements, fluorescence correlation spectroscopy, optical tweezers, quantum dots and DNA origami techniques. Both the text and illustrations have been prepared in a clear and accessible style, with extended and updated exercises (and their solutions) accompanying each chapter. Readers with a basic understanding of biochemistry and/or biophysics will quickly gain an overview of cutting edge technology for the biophysical analysis of proteins, nucleic acids and other biomolecules and their interactions. Equally, any student contemplating a career in the chemical, pharmaceutical or bio-industry will greatly benefit from the technological knowledge presented. Questions of differing complexity testing the reader's understanding can be found at the end of each chapter with clearly described solutions available on the Wiley-VCH textbook homepage under: www.wiley-vch.de/textbooks
| Author | : Wolfgang Becker |
| Publisher | : Springer |
| Total Pages | : 642 |
| Release | : 2015-04-13 |
| Genre | : Science |
| ISBN | : 3319149296 |
This book is an attempt to bridge the gap between the instrumental principles of multi-dimensional time-correlated single photon counting (TCSPC) and typical applications of the technique. Written by an originator of the technique and by sucessful users, it covers the basic principles of the technique, its interaction with optical imaging methods and its application to a wide range of experimental tasks in life sciences and clinical research. The book is recommended for all users of time-resolved detection techniques in biology, bio-chemistry, spectroscopy of live systems, live cell microscopy, clinical imaging, spectroscopy of single molecules, and other applications that require the detection of low-level light signals at single-photon sensitivity and picosecond time resolution.
| Author | : Juliusz Ashot Kozak |
| Publisher | : CRC Press |
| Total Pages | : 343 |
| Release | : 2017-07-14 |
| Genre | : Science |
| ISBN | : 149875273X |
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
| Author | : Robin Liu |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 216 |
| Release | : 2008-12-03 |
| Genre | : Medical |
| ISBN | : 0387767592 |
The objective of this book is to provide up-to-date coverage of some of the emerging developments in the field of integrated DNA biochips. It will prove a useful source of information for researchers in the field and for those who are just entering the field of biochip research.
| Author | : Nelu Grinberg |
| Publisher | : CRC Press |
| Total Pages | : 975 |
| Release | : 2019-02-21 |
| Genre | : Medical |
| ISBN | : 1482218682 |
This handbook is a guide for workers in analytical chemistry who need a starting place for information about a specific instrumental technique. It gives a basic introduction to the techniques and provides leading references on the theory and methodology for an instrumental technique. This edition thoroughly expands and updates the chapters to include concepts, applications, and key references from recent literature. It also contains a new chapter on process analytical technology.
| Author | : Bindesh Shrestha |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2019-09-30 |
| Genre | : Science |
| ISBN | : 9781493998296 |
This volume explores the latest techniques and workflow for the analysis of single cells metabolism. The chapters in this book cover topics such as the development of mass spectrometry-based single cell approaches, Pico-ESI-MS for single-cell metabolomics analysis; laser capture microdissection; ambient single cell metabolite profile (DESI and LAESI); and MALDI-MS methodology, quantum dots for quantitative cytology to study metabolic heterogeneity of single cells. Written in the highly successful Methods in Molecular Biology series format, the chapters consist of introductions to the topic, lists of the necessary materials and reagents, step-by-step guidelines, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Single Cell Metabolism: Methods and Protocols is a valuable resource for any researcher and scientist interested in learning more about this field.
| Author | : Li Kai |
| Publisher | : World Scientific |
| Total Pages | : 546 |
| Release | : 2010 |
| Genre | : Technology & Engineering |
| ISBN | : 9814295043 |
Held in Singapore from 9 to 11 October 2009, the 2009 International Conference on Chemical, Biological and Environmental Engineering (CBEE 2009) aims to provide a platform for researchers, engineers, academicians as well as industrial professionals from all over the world to present their research and development activities in chemical, biological and environmental engineering. Conference delegates will also have the opportunity to exchange new ideas and application experiences, establish business or research relations and find global partners for future collaboration. Sample Chapter(s). Chapter 1: The Future of Biopharmaceutics'' Production (92 KB). Contents: Study on Pyrolysis Characteristics of Electronic Waste (J Sun et al.); Application of Noise Mapping on Environmental Management (K-T Tsai et al.); Characteristics and Transport Properties of Two Modified Zero Valent Iron (Y-H Lin et al.); Synthesis of Visible Light Active N-Doped Titania Photocatalyst (C Kusumawardani et al.); CFD-PBM Modeling of Vertical Bubbly Flows (M R Rahimi & H Karimi); Hydrotalcite-Like Synthesis Using Magnesium from Brine Water (E Heraldy et al.); Cement/Activated-Carbon Solidification/Stabilization Treatment of Nitrobenzene (Z Su et al.); Investigation of Fish Species Biodiversity in Haraz River (I Piri et al.); Risk Assessment of Fluoride in Indian Context (V Chaudhary & M Kumar); Light Transmission In Fluidized Bed (E Shahbazali et al.); Drying of Mushroom Using a Solar Tunnel Dryer (M A Basunia et al.); and other papers. Readership: Researchers, engineers, academicians and industrial professionals in related fields of chemical, biological and environmental engineering.
