Senescence And Rejuvenation
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| Author | : Aubrey de Grey |
| Publisher | : Macmillan + ORM |
| Total Pages | : 452 |
| Release | : 2007-09-04 |
| Genre | : Science |
| ISBN | : 1429931833 |
MUST WE AGE? A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging. Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach. In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.
| Author | : Jörg Reichrath |
| Publisher | : Springer Nature |
| Total Pages | : 428 |
| Release | : 2020-09-11 |
| Genre | : Medical |
| ISBN | : 3030462277 |
The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.
| Author | : Tadashi Dohi |
| Publisher | : World Scientific |
| Total Pages | : 424 |
| Release | : 2020-04-22 |
| Genre | : Computers |
| ISBN | : 9811214581 |
The Handbook of Software Aging and Rejuvenation provides a comprehensive overview of the subject, making it indispensable to graduate students as well as professionals in the field. It begins by introducing fundamental concepts, definitions, and the history of software aging and rejuvenation research, followed by methods, tools, and strategies that can be used to detect, analyze, and overcome software aging.
| Author | : Yuelin Zhang |
| Publisher | : Frontiers Media SA |
| Total Pages | : 154 |
| Release | : 2022-01-18 |
| Genre | : Science |
| ISBN | : 2889740633 |
| Author | : Naofumi Shiomi |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 128 |
| Release | : 2016-08-31 |
| Genre | : Medical |
| ISBN | : 9535125680 |
Numerous studies had been performed to elucidate the mechanisms of aging and to achieve rejuvenation, with some success reported in recent years. However, at present, the findings from those studies are not sufficient to resolve the issue of aging. This book presents an overview of recent topics on cellular aging and rejuvenation. In the early chapters, the molecular mechanisms of aging via the activities of clock and ion channel proteins, in addition to overall aspects, are discussed. In the latter part, the aging of the skin, immune system, and brain is discussed. This book will prove useful for those studying or developing new drugs to counter the aging process and will encourage the development of novel ideas for rejuvenation.
| Author | : Michael S. Goligorsky |
| Publisher | : Academic Press |
| Total Pages | : 473 |
| Release | : 2010-11-26 |
| Genre | : Science |
| ISBN | : 0123809290 |
Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts. - Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers - Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney
| Author | : Ashraf Badawi |
| Publisher | : Springer Nature |
| Total Pages | : 180 |
| Release | : 2020-11-11 |
| Genre | : Medical |
| ISBN | : 3030468666 |
This title represents a comprehensive manual of periorbital rejuvenation and includes an in-depth review of the anatomy of the orbit and periorbital region. Physiological changes associated with the aging of the periorbital region and potential rejuvenation options are also covered, while readers are given a series of step-by-step illustrative guides to procedural techniques. The book provides a valuable selection of clinical pearls on how to avoid potential pitfalls using a number of cases in which a range of potential invasive and non-invasive treatment options, including neuromodulators and cosmeceuticals, are used. Periorbital Rejuvenation: A Practical Manual provides a comprehensive and concise overview of periorbital anatomy and the potential effects of aging. Cutting-edge laser treatment options including laser assisted and neuromodulator techniques are ideal for the trainee to develop their knowledge and as a reference guide for the experienced practitioner.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 320 |
| Release | : 2020-08-07 |
| Genre | : Medical |
| ISBN | : 0128140860 |
Growing evidence suggests that epigenetic mechanisms play a central role in stem cell biology and are vital for determining gene expression during cellular differentiation and governing mammalian development. In Stem Cell Epigenetics, leading international researchers examine how chromatin regulation and bona fide epigenetic mechanisms underlie stem cell renewal and differentiation. Authors also explore how the diversity of cell types, including the extent revealed by single cell omic approaches, is achieved, and how such processes may be reversed or managed via epigenetic reprogramming.Topics discussed include chromatin in pluripotency, stem cells and DNA methylation, histone modifications in stem cells and differentiation, higher-order chromatin conformation in pluripotent cells, stem cells and cancer, epigenetics and disease modeling, brain organoids from pluripotent cells, transcriptional regulation in stem cells and differentiation, non-coding RNAs in pluripotency and early differentiation, and diseases caused by epigenetic alterations in stem cells. Additionally, the book discusses the potential implementation of stem cell epigenetics in drug discovery, regenerative medicine, and disease treatment. Stem Cell Epigenetics will provide researchers and physicians with a state-of-the-art map to orient across the frontiers of this fast-evolving field. - Analyzes the role of epigenetics in embryonic stem cell regulation - Indicates the epigenetic mechanisms involved in stem cell differentiation and highlights modifications and misregulations that may result in disease pathogenesis - Examines the potential applications of stem cell epigenetics in therapeutic disease interventions and regenerative medicine, providing a foundation for researchers and physicians to bring this exciting and fast-evolving field into a clinical setting - Features chapter contributions by leading international experts
| Author | : Bernard Swynghedauw |
| Publisher | : |
| Total Pages | : 121 |
| Release | : 2019 |
| Genre | : Family medicine |
| ISBN | : 9783030151126 |
This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for "treating" it. Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related "chronic non-transmissible diseases"), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to "treat" or "prevent" the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria. Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians.
| Author | : Helena Lenasi |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 432 |
| Release | : 2018-10-24 |
| Genre | : Medical |
| ISBN | : 1789842530 |
The endothelium enables communication between blood and tissues and is actively involved in cardiovascular homeostasis. Endothelial dysfunction has been recognized as an early step in the development of cardiovascular diseases: respectively, endothelium represents a potential therapeutic niche with multiple targets. The purpose of the book is to point out some recent findings of endothelial physiology and pathophysiology emphasizing various aspects of endothelial dysfunction connected to the body's internal and external environment. While basic features of the endothelium are presented in an introductory chapter, the authors of the following 17 chapters have provided extensive insight into some selected topics of endothelial (dys)function. The book would hopefully be useful for anyone interested in recapitulating endothelial (patho)physiology and expanding knowledge of molecular mechanisms involved in endothelial dysfunction, relevant also for further clinical investigations.
