Selected Papers Of Frederick Sanger
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Author | : Frederick Sanger |
Publisher | : World Scientific |
Total Pages | : 680 |
Release | : 1996 |
Genre | : Science |
ISBN | : 9789810224301 |
This important volume is mainly concerned with the development of methods for ?sequencing? ? that is, determination of the order of the amino acids in proteins and of nucleotides in RNA and DNA. In 1943 the position of only one amino acid in a protein (insulin) was known, and Sanger's first paper resulted in finding a second amino acid. In his final paper in 1982 he describes the determination of a DNA sequence of 48,502 nucleotides. The papers describe the steady improvements in techniques, and exciting biological results revealed by the sequences.
Author | : Joe S. Jeffers |
Publisher | : Springer |
Total Pages | : 94 |
Release | : 2017-03-14 |
Genre | : Science |
ISBN | : 3319547097 |
In this Brief, Joe Jeffers uncovers the life and works of two-time Nobel Laureate Frederick Sanger. Following Sanger’s early life to retirement, Jeffers describes how this celebrated British biochemist became the first person to determine the amino acid sequence of a protein for which he was awarded the Nobel Prize in 1958. Highlighting Sanger’s remarkable career, Jeffers describes Sanger’s later change in research direction to investigate deoxyribonucleic acids (DNA), work for which Sanger also received the Nobel Prize jointly with Paul Berg and Walter Gilbert in 1980. Joe Jeffers conducted twelve interviews with Sanger over the period of 1999-2009 and he has also spoken to more than 40 of Sanger’s colleagues and family members. This brief provides a rigorous yet concise view of Sanger on a personal and scientific level and is suitable for biochemists, historians or the interested layperson.
Author | : H Gobind Khorana |
Publisher | : World Scientific |
Total Pages | : 633 |
Release | : 2000-05-24 |
Genre | : Science |
ISBN | : 9814496650 |
The first two chapters of this invaluable book trace the developments of the chemistry and macromolecular structures, respectively, of proteins and nuclei acids. Similarly, the introductions to the succeeding chapters review, step by step, the historical landmarks in the topics covered. These include discoveries of biological phosphate esters, nucleotides and nucleotide coenzymes (important in intermediary metabolism), the nature of the genetic material and biological synthesis of proteins, formulation of the problem of the genetic code, and perspectives on bioenergetics.The selected papers illustrate the developments of the chemical synthesis of nucleotides and nucleotide coenzymes of ribo- and deoxy-ribo-polynucleotides (RNA, DNA), of the total synthesis of genes in the laboratory, and principles for gene amplification (PCR). Another major section covers studies of enzymes that degrade nucleic acids, the structure of transfer RNA and its role in protein synthesis, and the author's work on the elucidation of the genetic code. Finally, there are descriptions of the studies on biological membranes and the membrane protein bacteriorhodopsin, a biological proton pump. These studies elucidated the mechanism of proton translocation, which is central to bioenergetics.
Author | : James D. Watson |
Publisher | : Macmillan |
Total Pages | : 500 |
Release | : 2007 |
Genre | : Medical |
ISBN | : 9780716728665 |
Recombinant DNA, Third Edition, is an essential text for undergraduate, graduate, and professional courses in Genomics, Cell and Molecular Biology, Recombinant DNA, Genetic Engineering, Human Genetics, Biotechnology, and Bioinformatics. The Third Edition of this landmark text offers an authoritative, accessible, and engaging introduction to modern, genome-centered biology from its foremost practitioners. The new edition explores core concepts in molecular biology in a contemporary inquiry-based context, building its coverage around the most relevant and exciting examples of current research and landmark experiments that redefined our understanding of DNA. As a result, students learn how working scientists make real high-impact discoveries. The first chapters provide an introduction to the fundamental concepts of genetics and genomics, an inside look at the Human Genome Project, bioinformatic and experimental techniques for large-scale genomic studies, and a survey of epigenetics and RNA interference. The final chapters cover the quest to identify disease-causing genes, the genetic basis of cancer, and DNA fingerprinting and forensics. In these chapters the authors provide examples of practical applications in human medicine, and discuss the future of human genetics and genomics projects.
Author | : George G. Brownlee |
Publisher | : Cambridge University Press |
Total Pages | : 229 |
Release | : 2014-11-06 |
Genre | : Biography & Autobiography |
ISBN | : 1107083346 |
The first biography of Fred Sanger, shedding light on his remarkable life and career and exploring his continuing legacy.
Author | : George G. Brownlee |
Publisher | : Cambridge University Press |
Total Pages | : 315 |
Release | : 2020-04-02 |
Genre | : Science |
ISBN | : 1316124053 |
Considered 'the father of genomics', Fred Sanger (1918–2013) paved the way for the modern revolution in our understanding of biology. His pioneering methods for sequencing proteins, RNA and, eventually, DNA earned him two Nobel Prizes. He remains one of only four scientists (and the only British scientist) ever to have achieved that distinction. In this, the first full biography of Fred Sanger to be published, Brownlee traces Sanger's life from his birth in rural Gloucestershire to his retirement in 1983 from the Medical Research Council's Laboratory of Molecular Biology in Cambridge. Along the way, he highlights the remarkable extent of Sanger's scientific achievements and provides a real portrait of the modest man behind them. Including an extensive transcript of a rare interview of Sanger by the author, this biography also considers the wider legacy of Sanger's work, including his impact on the Human Genome Project and beyond.
Author | : Elaine Dewar |
Publisher | : Vintage Canada |
Total Pages | : 662 |
Release | : 2010-07-07 |
Genre | : Science |
ISBN | : 0307368912 |
The Second Tree documents a biological revolution that will change the way you think about the material world, your own life and even the inevitability of your own death Genetic scientists are busily pushing back the boundaries of the humanly possible, climbing the branches of a tree of life that has been grafted by man, not God. Elaine Dewar chronicles the lives, the discoveries, and the feuds among modern biologists, exploring how they have crafted the tools to alter human evolution. She travels the globe on the trail of Charles Darwin and his intellectual descendants, telling the story of James D. Watson and his partner Francis Crick, who first described DNA; of Frederick Sanger, who invented how to sequence genes and won two Nobel prizes; of the computer scientists who put the human genome on the World Wide Web. She visits companies that are trying to turn cloned sheep into pharmacies on the hoof, to resurrect prize cows from the grave, to transplant human genes into mice — ultimately attempting to give us immortality in pieces while trying to keep investors happy. As these tales spill out, we find out how biologists learn by doing: tearing mice and worms and flies and human eggs apart, twinning disparate animal cells and genes together — creating clones and chimeras as outlandish as any sphinx. In public, research biologists often express their good intentions about curing the big diseases. In private, many of them are compelled by furious struggles to be rich, famous and first. Dewar lays bare the motives, conflicts and fears of the men and women whose job it is to trespass the boundaries of what laypeople consider ethical and sacred.
Author | : Margaret Sanger |
Publisher | : University of Illinois Press |
Total Pages | : 635 |
Release | : 2016-10-01 |
Genre | : Biography & Autobiography |
ISBN | : 0252098803 |
When Margaret Sanger returned to Europe in 1920, World War I had altered the social landscape as dramatically as it had the map of Europe. Population concerns, sexuality, venereal disease, and contraceptive use had entered public discussion, and Sanger's birth control message found receptive audiences around the world. This volume focuses on Sanger from her groundbreaking overseas advocacy during the interwar years through her postwar role in creating the International Planned Parenthood Federation. The documents reconstruct Sanger's dramatic birth control advocacy tours through early 1920s Germany, Japan, and China in the midst of significant government and religious opposition to her ideas. They also trace her tireless efforts to build a global movement through international conferences and tours. Letters, journal entries, writings, and other records reveal Sanger's contentious dealings with other activists, her correspondence with the likes of Albert Einstein and Eleanor Roosevelt, and Sanger's own dramatic evolution from gritty grassroots activist to postwar power broker and diplomat. A powerful documentary history of a transformative twentieth-century figure, The Selected Papers of Margaret Sanger, Volume 4 is a primer for the debates on individual choice, sex education, and planned parenthood that remain all-too-pertinent in our own time.
Author | : Sandrine Dudoit |
Publisher | : Springer Science & Business Media |
Total Pages | : 685 |
Release | : 2012-04-11 |
Genre | : Mathematics |
ISBN | : 1461413478 |
The purpose of this volume is to provide an overview of Terry Speed’s contributions to statistics and beyond. Each of the fifteen chapters concerns a particular area of research and consists of a commentary by a subject-matter expert and selection of representative papers. The chapters, organized more or less chronologically in terms of Terry’s career, encompass a wide variety of mathematical and statistical domains, along with their application to biology and medicine. Accordingly, earlier chapters tend to be more theoretical, covering some algebra and probability theory, while later chapters concern more recent work in genetics and genomics. The chapters also span continents and generations, as they present research done over four decades, while crisscrossing the globe. The commentaries provide insight into Terry’s contributions to a particular area of research, by summarizing his work and describing its historical and scientific context, motivation, and impact. In addition to shedding light on Terry’s scientific achievements, the commentaries reveal endearing aspects of his personality, such as his intellectual curiosity, energy, humor, and generosity.
Author | : David Eagleman |
Publisher | : Catapult |
Total Pages | : 404 |
Release | : 2017-10-10 |
Genre | : Psychology |
ISBN | : 1936787679 |
This enlightening examination of creativity looks “at art and science together to examine how innovations . . . build on what already exists and rely on three brain operations: bending, breaking and blending” (The Wall Street Journal) The Runaway Species is a deep dive into the creative mind, a celebration of the human spirit, and a vision of how we can improve our future by understanding and embracing our ability to innovate. David Eagleman and Anthony Brandt seek to answer the question: what lies at the heart of humanity’s ability—and drive—to create? Our ability to remake our world is unique among all living things. But where does our creativity come from, how does it work, and how can we harness it to improve our lives, schools, businesses, and institutions? Eagleman and Brandt examine hundreds of examples of human creativity through dramatic storytelling and stunning images in this beautiful, full–color volume. By drawing out what creative acts have in common and viewing them through the lens of cutting–edge neuroscience, they uncover the essential elements of this critical human ability, and encourage a more creative future for all of us. “The Runaway Species approach[es] creativity scientifically but sensitively, feeling its roots without pulling them out.” —The Economist