This book constitutes the proceedings of the 22nd International Conference on Speech and Computer, SPECOM 2020, held in St. Petersburg, Russia, in October 2020. The 65 papers presented were carefully reviewed and selected from 160 submissions. The papers present current research in the area of computer speech processing including speech science, speech technology, natural language processing, human-computer interaction, language identification, multimedia processing, human-machine interaction, deep learning for audio processing, computational paralinguistics, affective computing, speech and language resources, speech translation systems, text mining and sentiment analysis, voice assistants, etc. Due to the Corona pandemic SPECOM 2020 was held as a virtual event.