Long neglected in the history of Renaissance and early modern Europe, in recent years scholars have revised received understanding of the political and economic significance of the city of Naples and its rich artistic, musical and political culture. Its importance in the history of science, however, has remained relatively unknown. The Science of Naples provides the first dedicated study of Neapolitan scientific culture in the English language. Drawing on contributions from leading experts in the field, this volume presents a series of studies that demonstrate Neapolitans’ manifold contributions to European scientific culture in the early modern period and considers the importance of the city, its institutions and surrounding territories for the production of new knowledge. Individual chapters demonstrate the extent to which Neapolitan scholars and academies contributed to debates within the Republic of Letters that continued until deep into the nineteenth century. They also show how studies of Neapolitan natural disasters yielded unique insights that contributed to the development of fields such as medicine and earth sciences. Taken together, these studies resituate the city of Naples as an integral part of an increasingly globalised scientific culture, and present a rich and engaging portrait of the individuals who lived, worked and made scientific knowledge there.