Salvinorin

Salvinorin
Author: D. M. Turner
Publisher: Panther Press (TN)
Total Pages: 57
Release: 1996
Genre: Salvia divinorum
ISBN: 9780964263628

Drug Addiction

Drug Addiction
Author: Rao S. Rapaka
Publisher: Springer Science & Business Media
Total Pages: 791
Release: 2008-06-19
Genre: Medical
ISBN: 0387766782

This book provides a comprehensive overview of physiological, biochemical, and genetic pathways underlying drug addiction, and resultant efforts to develop novel treatment strategies dealing with drug addiction and other CNS disorders where the neurophysiological processes overlap, such as treatment of pain. The volume focuses on the translation of fundamental addiction research to a variety of treatments and brings together scientists with wide ranging expertise.

Opioids and Their Receptors

Opioids and Their Receptors
Author: Mariana Spetea
Publisher: MDPI
Total Pages: 358
Release: 2020-12-18
Genre: Medical
ISBN: 3036500464

The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistry and pharmacology of new ligands targeting the opioid receptors as effective and safe therapeutics for human diseases. Furthermore, it draws a special attention to advancing concepts and strategies in opioid drug discovery to mitigate opioid liabilities. The diversity among the discussed topics is a testimony to the complexity of the opioid system, which results from the expression, regulation, and functional role of ligands and receptors. The array of multidisciplinary research areas illustrates the rapidly developing basic research and translational activities in opioid drug discovery. This book will serve as a useful reference while also stimulating continued research in the chemistry and pharmacology of opioids and their receptors, with the prospect of developing improved therapies for human diseases, but also improving health and quality of life in general.

Handbook of Medical Hallucinogens

Handbook of Medical Hallucinogens
Author: Charles S. Grob
Publisher: Guilford Publications
Total Pages: 602
Release: 2023-01-13
Genre: Medical
ISBN: 1462551890

This handbook reviews promising applications of psychedelics in treatment of such challenging psychiatric problems as posttraumatic stress disorder, major depression, substance use disorders, and end-of-life anxiety. Experts from multiple disciplines synthesize current knowledge on psilocybin, MDMA, ketamine, and other medical hallucinogens. The volume comprehensively examines these substances' neurobiological mechanisms, clinical effects, therapeutic potential, risks, and anthropological and historical contexts. Coverage ranges from basic science to practical clinical considerations, including patient screening and selection, dosages and routes of administration, how psychedelic-assisted sessions are structured and conducted, and management of adverse reactions.

Drugs of the Dreaming

Drugs of the Dreaming
Author: Gianluca Toro
Publisher: Simon and Schuster
Total Pages: 107
Release: 2007-05-21
Genre: Body, Mind & Spirit
ISBN: 1594777454

The first comprehensive guide to oneirogens--naturally occurring substances that induce and enhance dreaming • Includes extensive monographs on dream-enhancing substances derived from plant, animal, and human sources • Presents the results of scientific experiments on the effects of using oneirogens • Shows how studies in this area of ethnobotany can yield a scientific understanding of the mysterious mechanism of dreams Oneirogens are plant and animal substances that have long been used to facilitate powerful and productive dreaming. From the beginning of civilization, dreams have guided the inner and outer life of human beings both in relation to each other and to the divine. For centuries shamans have employed oneirogens in finding meaning and healing in their dreams. Drugs of the Dreaming details the properties and actions of these dream allies, establishing ethnobotanical profiles for 35 oneirogens, including those extracted from organic sources--such as Calea zacatechichi (dream herb or “leaf of the god”), Salvia divinorum, and a variety of plants from North and South America and the Pacific used in shamanic practices--as well as synthetically derived oneirogens. They explain the historical use of each oneirogen, its method of action, and what light it sheds on the scientific mechanism of dreaming. They conclude that oneirogens enhance the comprehensibility and facility of the dream/dreamer relationship and hold a powerful key for discerning the psychological needs and destinies of dreamers in the modern world.

Exploration of Salvinorin A Chemical Space

Exploration of Salvinorin A Chemical Space
Author: Sarah Jane Hill
Publisher:
Total Pages: 0
Release: 2023
Genre: Salvinorin A.
ISBN:

The salvinorins serve as templates for next generation analgesics, antipruritics and dissociative hallucinogens via selective and potent agonism of the kappa-opioid receptor (KOR). In contrast to most opioids, the salvinorins lack basic amines and bind with high affinity and selectivity via complex polyoxygenated scaffolds that have frustrated deep-seated modification by synthesis. Here we describe a short asymmetric synthesis that relies on a sterically-confined organocatalyst to dissociate acidity from reactivity and effect Robinson annulation of an unactivated nucleophile / unstable electrophile pair. Combined with a cobalt-catalyzed polarized diene-alkyne cycloaddition, the route allows divergent access to a focused library of salvinorins. We appraise the synthesis by its generation of multiple analogs that exceed the potency, selectivity, stability and functional bias of salvinorin A itself.

Shamanic Quest for the Spirit of Salvia

Shamanic Quest for the Spirit of Salvia
Author: Ross Heaven
Publisher: Simon and Schuster
Total Pages: 214
Release: 2013-05-20
Genre: Body, Mind & Spirit
ISBN: 1620551489

The first practical guide to the transformative uses of salvia • Explains how salvia connects you with your higher purpose and aids you in envisioning your unique path in life • Describes appropriate methods of use, a shamanic diet to increase effectiveness, and the meaning of the symbols experienced during salvia’s ecstatic embrace • Explores recent clinical research into salvia’s long-term positive psychological effects and its potential as a treatment for Alzheimer’s, depression, and addiction Salvia divinorum has been used since ancient times by the Mazatec shamans of Mexico for divination, vision quests, and healing. Known by many names--nearly all associated with the Virgin Mary, who has come to symbolize the spirit of salvia--this plant ally is now regarded as the most powerful natural hallucinogen. Providing the first practical guide to the shamanic, spiritual, and therapeutic uses of salvia, Ross Heaven shares his in-depth quest to connect with the spirit of this plant teacher. He explores recent clinical research into its many long-term psychological effects, such as increased insight and self-confidence, improved mood and concentration, and feelings of calmness and connection with nature, as well as salvia’s potential for combating diseases like Alzheimer’s, depression, and even cocaine addiction. Reviewing the traditional Mazatec ceremonies surrounding salvia’s harvest and use, Heaven describes appropriate methods of consumption, typical dosages, and the shamanic diet he used to increase salvia’s effectiveness. Examining firsthand accounts of salvia journeys from around the world, he decodes the meaning of the symbolic images experienced during salvia’s ecstatic embrace and details the interplay between salvia and the lucid dreaming state. Comparing salvia to ayahuasca and the San Pedro cactus, Heaven explains that salvia’s greatest strength as a shamanic plant ally lies in its ability to connect you with your higher purpose and aid you in envisioning your unique path in life.

The ASAM Principles of Addiction Medicine

The ASAM Principles of Addiction Medicine
Author: Shannon C. Miller
Publisher: Lippincott Williams & Wilkins
Total Pages: 5147
Release: 2024-02-15
Genre: Medical
ISBN: 1975201574

Principles of Addiction Medicine, 7th ed is a fully reimagined resource, integrating the latest advancements and research in addiction treatment. Prepared for physicians in internal medicine, psychiatry, and nearly every medical specialty, the 7th edition is the most comprehensive publication in addiction medicine. It offers detailed information to help physicians navigate addiction treatment for all patients, not just those seeking treatment for SUDs. Published by the American Society of Addiction Medicine and edited by Shannon C. Miller, MD, Richard N. Rosenthal, MD, Sharon Levy, MD, Andrew J. Saxon, MD, Jeanette M. Tetrault, MD, and Sarah E. Wakeman, MD, this edition is a testament to the collective experience and wisdom of 350 medical, research, and public health experts in the field. The exhaustive content, now in vibrant full color, bridges science and medicine and offers new insights and advancements for evidence-based treatment of SUDs. This foundational textbook for medical students, residents, and addiction medicine/addiction psychiatry fellows, medical libraires and institution, also serves as a comprehensive reference for everyday clinical practice and policymaking. Physicians, mental health practitioners, NP, PAs, or public officials who need reference material to recognize and treat substance use disorders will find this an invaluable addition to their professional libraries.