Role Of Proteomics In High Altitude Pathophysiology
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| Author | : Yasmin Ahmad |
| Publisher | : |
| Total Pages | : 94 |
| Release | : 2016-06-15 |
| Genre | : |
| ISBN | : 9781922227553 |
High altitude physiology is one of the ignored domain of the scientific research despite of the massive scale of the problem, suggested by nearly 24% of the global population that either visits or dwells at high altitude and remain at the risk of hypoxia associated alterations in physiology. This lecture note entitled "Role of Proteomics in High altitude Pathophysiology" is designed especially for those who are interested in learning proteomics and their application in the field of high altitude physiology. It meets the needs of the proteomics studies prescribed for the high altitude physiology as it covers pathophysiology and molecular biology of high altitude sickness, proteomics as powerful tools and major proteomic advancements on pathophysiology of acute mountain sickness. This lecture notes has 5 units and can be completed in two sessions. Initially, we introduced the term hypobaric hypoxia as a socio-economic problem followed by the description of its pathophysiology. The later chapters describe the role of proteomics and key findings of our lab. Finally a last concluding chapter includes the future guidelines for improving the health benefits of the ongoing research and developing novel strategies for future research. Though this lecture note has been designed for the students of biology field, it would be useful also for clinical professionals in the early stage of their career. It would be helpful to anyone who desires to enhance their knowledge in the field of high altitude physiology.
| Author | : Narendra Kumar Sharma |
| Publisher | : Springer Nature |
| Total Pages | : 222 |
| Release | : 2022-06-30 |
| Genre | : Medical |
| ISBN | : 9811910081 |
This book reviews the recent advances in the development of proteomics-based biomarkers for the non-invasive diagnosis of altitude sickness and explores the potential of antioxidant therapy for this sickness. The first chapters introduce the associated pathophysiology and provide mechanistic insights into the enhanced generation of reactive oxygen and nitrogen species (RONS), which leads to an increase in oxidative damage to lipids, proteins, and DNA. The book then highlights the current problems relating to the diagnosis and treatment of altitude sickness and summarizes novel approaches for identifying potential biomarkers and therapeutics. Lastly, it explores the therapeutic efficacy of antioxidant agents.
| Author | : W. Brendel |
| Publisher | : Springer |
| Total Pages | : 342 |
| Release | : 1982-05-24 |
| Genre | : Medical |
| ISBN | : |
High altitude physiology and medicine has again become important. The excep tional achievements of mountaineers who have climbed nearly all peaks over 8,000 m without breathing equipment raise the question of maximal adaptation ca pacity of man to low oxygen pressures. More importantly, the increase in tourism in the Andes and the Himalayas brings over 10,000 people to sites at altitudes above 4,000 and 5,000 m each year. At such heights several kinds of high alti tude diseases are likely to occur, and these complications require detailed medical investigations. Medical authorities need to inform both mountaineers and tourists as to how great a physical burden can be taken in the mountain environment without risk to health. Physicians need to know what kind of prophylaxis is to be employed at high altitudes to prevent the development of diseases and what therapeutic measures should be used once high altitude diseases have occurred. Moreover, the physical condition of the indigenous population living at higher altitudes such as the Andes and the Himalayas, who are exposed continuously to the stress of high altitude, requires our attention. We have become familiar with symptoms characteristic of chronic high-altitude disease: under special conditions this popu lation has a tendency to develop pulmonary hypertension, which is associated with pulmonary edema, pulmonary congestion, and right heart failure.
| Author | : Kshipra Misra |
| Publisher | : Academic Press |
| Total Pages | : 350 |
| Release | : 2018-07-19 |
| Genre | : Science |
| ISBN | : 0128140003 |
Management of High Altitude Pathophysiology presents a comprehensive overview on the various therapeutic practices and ongoing research relating to the development of more potent and novel formulations for managing high altitude pathophysiology. It provides a detailed application of both herbal and non-herbal therapeutic agents, including their nanoformulations. This important reference provides benefits to the medical and herbal scientific communities, doctors treating patients with high altitude complications, individuals travelling to high altitudes for recreation or work, and scientists working on future drug development. - Provides the recent advances and potential therapeutic agents for ameliorating the high-altitude complications - Includes herbal remedies for the prophylaxis and treatment of the high-altitude maladies - Elucidates the significance of Yogic practices and ergonomics in managing stress at high altitude
| Author | : Wolfgang Walz |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 271 |
| Release | : 2005-03-22 |
| Genre | : Medical |
| ISBN | : 1588293157 |
The advent of molecular techniques has shifted the focus of physiology from its traditional role as an integrative science concerned with the study of regulatory mechanisms leading to adaptation and homeostasis, to a field preoccupied with the problems and challenges inherent in those techniques. In Integrative Physiology in the Proteomics and Post-Genomics Age, internationally recognized researchers highlight the major questions and accomplishments of modern physiological research and demonstrate that modern molecular methods can well be incorporated and strengthen the original integrative perspectives of physiology set out by Claude Bernard's concept of the "milieu interieur." Among the critical issues discussed are the place of functional genomics in regulatory physiology, the role of model systems in integrative physiology, the function of neural circuits in behavior and consciousness, and the influence of external challenges to the whole body and the environment on genes. The question of integrative physiology in curriculum design for the health sciences is also discussed. Perceptive and timely, Integrative Physiology in the Proteomics and Post-Genomics Age bridges the gap between molecular biology and whole body function, establishing the future of physiology as an integrative science based on new molecular insights.
| Author | : Sandro Malacrida |
| Publisher | : Frontiers Media SA |
| Total Pages | : 111 |
| Release | : 2022-05-25 |
| Genre | : Science |
| ISBN | : 2889762122 |
| Author | : Hans-Dieter Volk |
| Publisher | : Frontiers Media SA |
| Total Pages | : 178 |
| Release | : 2022-11-30 |
| Genre | : Medical |
| ISBN | : 2832507808 |
| Author | : Herbert N. Hultgren |
| Publisher | : |
| Total Pages | : 580 |
| Release | : 1997 |
| Genre | : Medical |
| ISBN | : |
| Author | : |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 170 |
| Release | : 2019-03-13 |
| Genre | : Medical |
| ISBN | : 1789857058 |
Knowledge of veterinary anatomy and physiology is essential for veterinary professionals and researchers. The chapters reflect the diverse and dynamic research being undertaken in a variety of different species throughout the world. Whether the animals have roles in food security, agriculture, or as companion, wild, or working animals, the lessons we learn impact on many areas of the profession. This book highlights research ranging from the cardiovascular and musculoskeletal systems, prostate and hoof, through to histopathology, imaging, and molecular techniques. It investigates both healthy and pathological conditions at differing stages of life. The importance of each cell and tissue through to the whole organism is explored alongside the methodologies used to understand these vital structures and functions.
| Author | : Andrew M Luks |
| Publisher | : CRC Press |
| Total Pages | : 555 |
| Release | : 2021-02-15 |
| Genre | : Medical |
| ISBN | : 0429814771 |
This pre-eminent work has developed over six editions in response to man's attempts to climb higher and higher unaided, and to spend more time at altitude for both work and recreation. Building on this established reputation, the new and highly experienced authors provide a fully revised and updated text that will help doctors continue to improve the health and safety of all people who visit, live or work in the cold, thin air of high mountains. The sixth edition remains invaluable for any doctor accompanying an expedition or advising patients on a visit to altitude, those specialising in illness and accidents in high places, and for physicians and physiologists who study our dependence on oxygen and the adaptation of the body to altitude.
