Rna Technologies And Their Applications
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| Author | : Volker A. Erdmann |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 460 |
| Release | : 2010-09-02 |
| Genre | : Medical |
| ISBN | : 3642121683 |
RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 354 |
| Release | : 2012-09-13 |
| Genre | : Science |
| ISBN | : 0309224187 |
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
| Author | : R. K. Gaur |
| Publisher | : CRC Press |
| Total Pages | : 388 |
| Release | : 2016-04-19 |
| Genre | : Science |
| ISBN | : 1439873259 |
RNAi technology is used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. Introducing new technology in the study of RNA
| Author | : Krishnarao Appasani |
| Publisher | : Cambridge University Press |
| Total Pages | : 564 |
| Release | : 2005-01-17 |
| Genre | : Science |
| ISBN | : 9781139442657 |
RNA Interference (RNAi) technology has rapidly become one of the key methods used in functional genomics. RNAi is used to block the expression of genes and create phenotypes that can potentially yield clues about the function of these genes. In the postgenomic era, the elucidation of the physiological function of genes has become the rate-limiting step in the quest to develop 'gene-based drugs' and RNAi could potentially play a pivotal role in the validation of such novel drugs. In this overview, the basic concepts and applications of RNAi biology are discussed. Leading experts from both academia and industry have contributed to this invaluable reference. The volume is forwarded by Andrew Fire, one of the winners of the 2006 Nobel Prize for the discovery of RNA Interference.
| Author | : Jane K. Setlow |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 234 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1461570840 |
Eleven contributions address topics that include: DNA methylases; the application of antisense RNA technology to plants; molecular genetics of self incompatibility; pulsed-field gel electrophoresis. Annotation copyright Book News, Inc. Portland, Or.
| Author | : Anirudh Kumar |
| Publisher | : Springer Nature |
| Total Pages | : 354 |
| Release | : 2021-08-05 |
| Genre | : Technology & Engineering |
| ISBN | : 9811629560 |
This edited book brings out a comprehensive collection of information on the modern omics-based research. The main focus of this book is to educate researchers about utility of omics-based technologies in rapid crop improvement. In last two decades, omics technologies have been utilized significantly in the area of plant sciences and has shown promising results. Omics technology has potential to address the challenge of food security in the near future. The comprehensive use of omics technology occurred in last two decades and helped greatly in the understanding of complex biological problems, improve crop productivity and ensure sustainable use of ecosystem services. This book is of interest to researchers and students of life sciences, biotechnology, plant biotechnology, agriculture, forestry, and environmental sciences. It is also a useful knowledge resource for national and international agricultural scientists.
| Author | : Paul Pumpens |
| Publisher | : CRC Press |
| Total Pages | : 616 |
| Release | : 2020-02-03 |
| Genre | : Science |
| ISBN | : 042967290X |
This is a comprehensive guide to single-stranded RNA phages (family Leviviridae), first discovered in 1961. These phages played a unique role in early studies of molecular biology, the genetic code, translation, replication, suppression of mutations. Special attention is devoted to modern applications of the RNA phages and their products in nanotechnology, vaccinology, gene discovery, evolutionary and environmental studies. Included is an overview of the generation of novel vaccines, gene therapy vectors, drug delivery, and diagnostic tools exploring the role of RNA phage-derived products in the revolutionary progress of the protein tethering and bioimaging protocols. Key Features Presents the first full guide to single-stranded RNA phages Reviews the history of molecular biology summarizing the role RNA phages in the development of the life sciences Demonstrates how RNA phage-derived products have resulted in nanotechnological applications Presents an up-to-date account of the role played by RNA phages in evolutionary and environmental studies
| Author | : Geng Chen |
| Publisher | : Frontiers Media SA |
| Total Pages | : 284 |
| Release | : 2022-10-17 |
| Genre | : Science |
| ISBN | : 2832502504 |
| Author | : Jayprokas Chakrabarti |
| Publisher | : Academic Press |
| Total Pages | : 578 |
| Release | : 2017-10-13 |
| Genre | : Medical |
| ISBN | : 0128134372 |
Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies. - Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics - Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis - Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies - Features contributions by leading experts in the field
| Author | : David P. Clark |
| Publisher | : Newnes |
| Total Pages | : 851 |
| Release | : 2015-05-16 |
| Genre | : Science |
| ISBN | : 0123850169 |
Biotechnology, Second Edition approaches modern biotechnology from a molecular basis, which has grown out of increasing biochemical understanding of genetics and physiology. Using straightforward, less-technical jargon, Clark and Pazdernik introduce each chapter with basic concepts that develop into more specific and detailed applications. This up-to-date text covers a wide realm of topics including forensics, bioethics, and nanobiotechnology using colorful illustrations and concise applications. In addition, the book integrates recent, relevant primary research articles for each chapter, which are presented on an accompanying website. The articles demonstrate key concepts or applications of the concepts presented in the chapter, which allows the reader to see how the foundational knowledge in this textbook bridges into primary research. This book helps readers understand what molecular biotechnology actually is as a scientific discipline, how research in this area is conducted, and how this technology may impact the future. - Up-to-date text focuses on modern biotechnology with a molecular foundation - Includes clear, color illustrations of key topics and concept - Features clearly written without overly technical jargon or complicated examples - Provides a comprehensive supplements package with an easy-to-use study guide, full primary research articles that demonstrate how research is conducted, and instructor-only resources
