Policymakers and technology development institutions have mostly focused on high-potential farming areas, which have better resource endowments and greater access to markets and infrastructure than less-favored areas. However, in developing nations more than one billion people live in less-favored areas, where, despite disadvantages, appropriate policies and programs can generate high returns and contribute significantly to poverty reduction. IFPRI and its partners' research in the highlands of Ethiopia shows how poverty and land degradation can be reduced in a less-favored area. Using a bioeconomic model to analyze the effects that land degradation, population growth, stagnant technology, market imperfections, and increased risk of drought have on household production, welfare, and food security, the report gauges how alternative policy choices affect poverty and land degradation. According to the study, land quality and household welfare are both in peril in the Ethiopian highlands.The population in the region could suffer devastating effects if proper policies are not put in place. The bioeconomic modeling approach used in this study can be usefully adapted and applied in many other settings and at larger spatial and socioeconomic scales.