Rheology Of Pharmaceutical Suspensions
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Pharmaceutical Suspensions
Author | : Alok K. Kulshreshtha |
Publisher | : Springer Science & Business Media |
Total Pages | : 337 |
Release | : 2009-11-05 |
Genre | : Medical |
ISBN | : 1441910875 |
The suspension dosage form has long been used for poorly soluble active ingre- ents for various therapeutic indications. Development of stable suspensions over the shelf life of the drug product continues to be a challenge on many fronts. A good understanding of the fundamentals of disperse systems is essential in the development of a suitable pharmaceutical suspension. The development of a s- pension dosage form follows a very complicated path. The selection of the proper excipients (surfactants, viscosity imparting agents etc.) is important. The particle size distribution in the finished drug product dosage form is a critical parameter that significantly impacts the bioavailability and pharmacokinetics of the product. Appropriate analytical methodologies and instruments (chromatographs, visco- ters, particle size analyzers, etc.) must be utilized to properly characterize the s- pension formulation. The development process continues with a successful scale-up of the manufacturing process. Regulatory agencies around the world require cli- cal trials to establish the safety and efficacy of the drug product. All of this devel- ment work should culminate into a regulatory filing in accordance with the regulatory guidelines. Pharmaceutical Suspensions, From Formulation Development to Manufacturing, in its organization, follows the development approach used widely in the pharmaceutical industry. The primary focus of this book is on the classical disperse system – poorly soluble active pharmaceutical ingredients s- pended in a suitable vehicle.
Suspension Concentrates
Author | : Tharwat F. Tadros |
Publisher | : Walter de Gruyter GmbH & Co KG |
Total Pages | : 362 |
Release | : 2017-02-20 |
Genre | : Science |
ISBN | : 3110486873 |
Suspension Concentrates is a survey into the theory of the formulation and stabilization of suspensions, elaborating on the breaking of aggregates and agglomerates and the role of dispersing agents on flocculation and electrostatic and steric stabilization. Practical analysis by rheology is discussed. Suspension Concentrates is ideal for research scientists and Ph.D. students investigating chemistry, chemical engineering and colloidal science.
Theory and Applications of Colloidal Suspension Rheology
Author | : Norman J. Wagner |
Publisher | : Cambridge University Press |
Total Pages | : 437 |
Release | : 2021-04-15 |
Genre | : Science |
ISBN | : 1108423035 |
Essential text on the practical application and theory of colloidal suspension rheology, written by an international coalition of experts.
Analytical Techniques in the Pharmaceutical Sciences
Author | : Anette Müllertz |
Publisher | : Springer |
Total Pages | : 829 |
Release | : 2016-08-30 |
Genre | : Medical |
ISBN | : 1493940295 |
The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood--from the characteristics of the individual formulation components, to how they act and interact within the formulation, and finally, to how this formulation responds in different biological environments. To achieve this, there is a wide range of analytical techniques that can be adopted to understand and elucidate the mechanics of drug delivery and drug formulation. Such methods include e.g. spectroscopic analysis, diffractometric analysis, thermal investigations, surface analytical techniques, particle size analysis, rheological techniques, methods to characterize drug stability and release, and biological analysis in appropriate cell and animal models. Whilst each of these methods can encompass a full research area in their own right, formulation scientists must be able to effectively apply these methods to the delivery system they are considering. The information in this book is designed to support researchers in their ability to fully characterize and analyze a range of delivery systems, using an appropriate selection of analytical techniques. Due to its consideration of regulatory approval, this book will also be suitable for industrial researchers both at early stage up to pre-clinical research.
Rheology of Polymer Blends and Nanocomposites
Author | : Sabu Thomas |
Publisher | : Elsevier |
Total Pages | : 324 |
Release | : 2019-09-08 |
Genre | : Technology & Engineering |
ISBN | : 0128169567 |
Rheology of Polymer Blends and Nanocomposites: Theory, Modelling and Applications focuses on rheology in polymer nanocomposites. It provides readers with a solid grounding in the fundamentals of rheology, with an emphasis on recent advancements. Chapters explore potential future applications for nanocomposites and polymer blends, giving readers a thorough understanding of the specific features derived from rheology as a tool for the study of polymer blends and nanocomposites. This book is ideal for industrial and academic researchers in the field of polymer blends and nanocomposites, but is also a great resource for anyone who wants to learn about the applications of rheology. Sets out the principles of rheology as it is applied to polymer blends and nanocomposites Demonstrates how rheological techniques are best applied to different classes of nanocomposites Assesses the opportunities and major challenges of rheological approaches to polymer blends and nanocomposites
Rheology of Non-spherical Particle Suspensions
Author | : Francisco Chinesta |
Publisher | : Elsevier |
Total Pages | : 398 |
Release | : 2015-10-06 |
Genre | : Science |
ISBN | : 0081008120 |
This book provides a review of the current understanding of the behavior of non-spherical particle suspensions providing experimental results, rheological models and numerical modeling. In recent years, new models have been developed for suspension rheology and as a result applications for nanocomposites have increased. The authors tackle issues within experimental, model and numerical simulations of the behavior of particle suspensions. Applications of non-spherical particle suspension rheology are widespread and can be found in organic matrix composites, nanocomposites, biocomposites, fiber-filled fresh concrete flow, blood and biologic fluids. Understand how to model and predict the final microstructure and properties of particle suspensions Explores nano, micro, meso and macro scales Rheology, thermomechanical and electromagnetic physics are discussed
Non-Newtonian Flow and Applied Rheology
Author | : R. P. Chhabra |
Publisher | : Butterworth-Heinemann |
Total Pages | : 535 |
Release | : 2011-04-08 |
Genre | : Technology & Engineering |
ISBN | : 0080951600 |
This book bridges the gap between the theoretical work of the rheologist, and the practical needs of those who have to design and operate the systems in which these materials are handled or processed. It is an established and important reference for senior level mechanical engineers, chemical and process engineers, as well as any engineer or scientist who needs to study or work with these fluids, including pharmaceutical engineers, mineral processing engineers, medical researchers, water and civil engineers. This new edition covers a considerably broader range of topics than its predecessor, including computational fluid dynamics modelling techniques, liquid/solid flows and applications to areas such as food processing, among others. Written by two of the world's leading experts, this is the only dedicated non-Newtonian flow reference in print. Since first publication significant advances have been made in almost all areas covered in this book, which are incorporated in the new edition, including developments in CFD and computational techniques, velocity profiles in pipes, liquid/solid flows and applications to food processing, and new heat/mass transfer methods and models. Covers both basic rheology and the fluid mechanics of NN fluids - a truly self-contained reference for anyone studying or working with the processing and handling of fluids