Revisiting the Metastatic Cascade: Putting Myeloid Cells Into Context
Author | : George S. Karagiannis |
Publisher | : Frontiers Media SA |
Total Pages | : 245 |
Release | : 2021-02-09 |
Genre | : Science |
ISBN | : 2889664678 |
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Author | : George S. Karagiannis |
Publisher | : Frontiers Media SA |
Total Pages | : 245 |
Release | : 2021-02-09 |
Genre | : Science |
ISBN | : 2889664678 |
Author | : Maija Hollmén |
Publisher | : Frontiers Media SA |
Total Pages | : 150 |
Release | : 2020-01-24 |
Genre | : |
ISBN | : 2889633934 |
Author | : Haritha Mathsyaraja |
Publisher | : |
Total Pages | : |
Release | : 2014 |
Genre | : |
ISBN | : |
Metastasis is the primary cause of mortality in breast cancer patients but the exact mechanisms governing malignant progression remain unclear. Recent studies have highlighted the role of the tumor microenvironment in promoting metastatic tumor growth. In particular, tumor associated macrophages (TAMs) are known to actively collaborate with tumor cells in mediating several steps of the metastatic cascade. Deciphering how tumor cells rewire regulatory networks in tumor associated macrophages (TAMs) will be critical for the development of effective therapies to combat metastatic disease. CSF1 or M-CSF is a key cytokine implicated in driving the proliferation, survival and differentiation of macrophages. It is well established that CSF1 plays a major role in the recruitment of TAMs to the primary tumor site. However, specific regulatory networks activated by CSF1 in the metastatic milieu are yet to be delineated.
Author | : Leonard Weiss |
Publisher | : Macmillan Reference USA |
Total Pages | : 362 |
Release | : 1978 |
Genre | : Medical |
ISBN | : |
Author | : Siddhartha Mukherjee |
Publisher | : Simon and Schuster |
Total Pages | : 624 |
Release | : 2011-08-09 |
Genre | : Health & Fitness |
ISBN | : 1439170916 |
Winner of the Pulitzer Prize and a documentary from Ken Burns on PBS, this New York Times bestseller is “an extraordinary achievement” (The New Yorker)—a magnificent, profoundly humane “biography” of cancer—from its first documented appearances thousands of years ago through the epic battles in the twentieth century to cure, control, and conquer it to a radical new understanding of its essence. Physician, researcher, and award-winning science writer, Siddhartha Mukherjee examines cancer with a cellular biologist’s precision, a historian’s perspective, and a biographer’s passion. The result is an astonishingly lucid and eloquent chronicle of a disease humans have lived with—and perished from—for more than five thousand years. The story of cancer is a story of human ingenuity, resilience, and perseverance, but also of hubris, paternalism, and misperception. Mukherjee recounts centuries of discoveries, setbacks, victories, and deaths, told through the eyes of his predecessors and peers, training their wits against an infinitely resourceful adversary that, just three decades ago, was thought to be easily vanquished in an all-out “war against cancer.” The book reads like a literary thriller with cancer as the protagonist. Riveting, urgent, and surprising, The Emperor of All Maladies provides a fascinating glimpse into the future of cancer treatments. It is an illuminating book that provides hope and clarity to those seeking to demystify cancer.
Author | : Claudia Mierke |
Publisher | : Iph001 |
Total Pages | : 500 |
Release | : 2018-10-24 |
Genre | : Science |
ISBN | : 9780750317511 |
This revised second edition is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion.
Author | : Robert A Weinberg |
Publisher | : Basic Books |
Total Pages | : 180 |
Release | : 2008-08-04 |
Genre | : Science |
ISBN | : 0786724013 |
Cancer research has reached a major turning point. The quality and quantity of information gathered about this disease in the past twenty years has revolutionized our understanding of its origins and behavior. No one is better qualified to comment on these dramatic leaps forward than molecular biologist Robert A. Weinberg, director of one of the leading cancer research centers in the world. In One Renegade Cell , Weinberg presents an accessible and state-of-the-art account of how the disease begins and how, one day, it will be cured. Weinberg tells how the roots of cancer were uncovered in 1909 and when the first cancer-causing virus was discovered. He then moves forward to the discovery of the role of chemical carcinogens and radiation in triggering cancer, and relates the remarkable story of the discoveries of oncogenes and tumor suppressor genes, the master controllers of normal and malignant cell proliferation. This book, which presumes little prior knowledge of biology, describes the revolution in biomedical research that has finally uncovered the forces driving malignant growth. Drawing on insights that simply were not available until recently, the discoveries presented in One Renegade Cell have already begun to profoundly alter the way that we diagnose and treat human cancers.
Author | : Bharat B. Aggarwal |
Publisher | : Springer |
Total Pages | : 489 |
Release | : 2014-05-12 |
Genre | : Medical |
ISBN | : 3034808372 |
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
Author | : Martine Extermann |
Publisher | : Springer |
Total Pages | : 1150 |
Release | : 2020-01-30 |
Genre | : Medical |
ISBN | : 9783319574141 |
This book is intended as a comprehensive resource for clinicians and researchers seeking in-depth information on geriatric oncology. The coverage encompasses epidemiology, the biology and (patho)physiology of aging and cancer, geriatric assessment and management, hematologic malignancies, solid tumors, issues in patient care, and research methods. Since cancer is a disease of aging and people are living longer, most cancer patients are now aged 70 and older. Yet the more we age, the more diverse we become in terms of our health, biologic fitness, and cancer behavior. Typically, however, general oncology clinical trials address only a selected healthier and younger population of patients. Geriatric oncology is the area of oncology that addresses these issues but while a wealth of knowledge has been accumulated, information is often difficult to retrieve or insufficiently detailed. The SpringerReference program, in which this book is published, offers an ideal format for overcoming these limitations since it combines thorough coverage with access to living editions constantly updated chapter by chapter via a dynamic peer-review process, ensuring that information remains current and pertinent.
Author | : Petranel T. Ferrao |
Publisher | : Frontiers Media SA |
Total Pages | : 186 |
Release | : 2019-11-01 |
Genre | : |
ISBN | : 288963115X |
Cancer cells can change and adapt, especially within the host environment; a phenomenon known as cancer plasticity. Several factors, including the immune system can influence, and be influenced by, cancer plasticity which in turn can impact upon patient responses to treatment. As such, we currently face several challenges for implementing combination therapies as effective cancer treatment strategies. We have compiled a topic with a number of articles that emphasize the various aspects of cancer plasticity, describing in particular the important role of the tumor microenvironment. As we embark on a new era of precision medicine with multi-modal therapies for improving patient outcomes, this topic highlights some relevant points for consideration that are pertinent to the incorporation and effective use of new treatments as part of cancer treatment regimens, including immune-modulating drugs.