Taking a holistic approach, this compilation gathers ecological, historical, and archaeological research written on the distinctive region of the US Southeast called the Gulf coast blackland prairie. Ranging from the last glacial period to the present day, the case studies provide a broad picture of how the area has changed through time and been modified by humans, first with nomadic bands of Indians trailing the grazing animals and then by Euro-American settlers who farmed the rich agricultural area. Contemporary impacts include industrialization, aquaculture, population growth, land reclamation, and wildlife management.