Resolving The Cholesterol Controversy: The Scientists Who Proved The Lipid Hypothesis Of Causation Of Atherosclerosis And Coronary Heart Disease

Resolving The Cholesterol Controversy: The Scientists Who Proved The Lipid Hypothesis Of Causation Of Atherosclerosis And Coronary Heart Disease
Author: Gilbert R Thompson
Publisher: World Scientific
Total Pages: 247
Release: 2023-06-20
Genre: Medical
ISBN: 1800613997

Resolving the Cholesterol Controversy recounts the science and scientific personalities behind the chain of discoveries upon which the lipid hypothesis of atherosclerosis was built.The narrative covers a period of just under 100 years, starting with Anitschkow's experiments with cholesterol-fed rabbits in 1913, and recounts the endeavours and achievements of the leading actors in this protracted scientific drama. The cast is drawn from an extraordinary variety of scientific disciplines: pathology, biophysics, epidemiology, nutrition, cardiology, lipidology, genetics, microbiology, pharmacology, and clinical trial design. Most of the scientists believed that cholesterol played a causal role in atherosclerosis and cardiovascular disease, but there were some who dissented strongly from this conclusion.The breadth of scientific disciplines involved in proving the lipid hypothesis is matched by the geographical spread of the participants. Anitschkow worked in Russia, Endo discovered the first statin in Japan, their commercial development by Merck took place in the USA and evidence of benefit from lowering cholesterol came from trials conducted in Scandinavia and the UK. The subsequent meta-analysis of these statin trials in 2005 proved the validity of the lipid hypothesis beyond any doubt. The history of how this all came about and its impact upon health policy and medical practice is recalled here in Resolving the Cholesterol Controversy.

Resolving the Cholesterol Controversy

Resolving the Cholesterol Controversy
Author: Gilbert R Thompson
Publisher: Wspc (Europe)
Total Pages: 0
Release: 2024-01-04
Genre: Medical
ISBN: 9781800615878

Resolving the Cholesterol Controversy recounts the science and scientific personalities behind the chain of discoveries upon which the lipid hypothesis of atherosclerosis was built. The narrative covers a period of just under 100 years, starting with Anitschkow's experiments with cholesterol-fed rabbits in 1913, and recounts the endeavours and achievements of the leading actors in this protracted scientific drama. The cast is drawn from an extraordinary variety of scientific disciplines: pathology, biophysics, epidemiology, nutrition, cardiology, lipidology, genetics, microbiology, pharmacology, and clinical trial design. Most of the scientists believed that cholesterol played a causal role in atherosclerosis and cardiovascular disease, but there were some who dissented strongly from this conclusion. The breadth of scientific disciplines involved in proving the lipid hypothesis is matched by the geographical spread of the participants. Anitschkow worked in Russia, Endo discovered the first statin in Japan, their commercial development by Merck took place in the USA and evidence of benefit from lowering cholesterol came from trials conducted in Scandinavia and the UK. The subsequent meta-analysis of these statin trials in 2005 proved the validity of the lipid hypothesis beyond any doubt. The history of how this all came about and its impact upon health policy and medical practice is recalled here in Resolving the Cholesterol Controversy.

Lipoproteins in Diabetes Mellitus

Lipoproteins in Diabetes Mellitus
Author: Alicia J. Jenkins
Publisher: Springer Nature
Total Pages: 925
Release: 2023-06-16
Genre: Medical
ISBN: 3031266811

Diabetes mellitus has become epidemic on a global scale, and millions of new cases are diagnosed every year. With an estimated 80% of people with diabetes living in disadvantaged regions, and the key roles of lipoproteins in the pathogenesis of the chronic complications of diabetes, this volume will be relevant to many readers globally. It is our intention that the contents will advance knowledge of the readers who will use it to contribute to the reduction of the burden associated with altered lipoproteins in people with diabetes. The second edition of this book provides an updated and comprehensive review of the field. The book, which includes many tables and figures, is presented in three main sections: (i) Lipoprotein metabolism, qualitative changes and measurements; (ii) Lipoproteins and the complications of diabetes; and (iii) the treatment of lipoproteins in diabetes. Each chapter from the first edition has been updated, and new topics added. New topics include the links between glycemia and lipoproteins, the role of lipoproteins in ischemic stroke, the diagnosis and management of statin intolerance (which is thought to be more common in people with diabetes) and the use of PCSK9 inhibitors and fish oils in the management of lipoproteins in people with diabetes. This book is written by an international group of experts in the clinical, laboratory and research aspects of lipoproteins in diabetes. Lipoproteins in Diabetes Mellitus, 2nd Edition is a comprehensive reference on the clinical and scientific aspects of lipoproteins in diabetes. It is a must-have resource for primary care and specialist clinicians, clinical and basic science researchers and to trainees and students.

Heart Failure

Heart Failure
Author: Thomas J. Moore
Publisher: Simon & Schuster
Total Pages: 324
Release: 1990
Genre: Health & Fitness
ISBN: 9780671724443

Covers controversies over angioplasty, cholesterol, diet, sudden cardiac death, heart bypass surgery, drugs in treatment of heart disease, etc.

Nutritional and Integrative Strategies in Cardiovascular Medicine

Nutritional and Integrative Strategies in Cardiovascular Medicine
Author: Stephen T. Sinatra
Publisher: CRC Press
Total Pages: 426
Release: 2021-05-28
Genre: Medical
ISBN: 1000555801

Building upon its predecessor, this new edition provides an in-depth review of the role of nutrition on cardiovascular health and disease. It provides scientific and clinical insight from leaders in the field of cardiovascular medicine who explore an integrative approach to treating and curing cardiovascular diseases through conventional and non allopathic methodologies. This evidence-based book describes how to integrate nutrition, supplements, lifestyle changes, and medications for improved outcomes in several diseases and conditions including hypertension, diabetes mellitus, metabolic syndrome, and obesity.

Meta Analysis in Medicine and Health Policy

Meta Analysis in Medicine and Health Policy
Author: Stangl/Berry
Publisher: CRC Press
Total Pages: 360
Release: 2000
Genre: Electronic books
ISBN: 0824742052

Analyses the data in health sciences and policy by introducing meta-analysis strategies while reviewing commonly used techniques. This text provides various chapters that build on principles, develop methodologies to solve statistical problems, and present concrete applications used by experienced medical practitioners and health policymakers.

Good Calories, Bad Calories

Good Calories, Bad Calories
Author: Gary Taubes
Publisher: Anchor
Total Pages: 641
Release: 2008-09-23
Genre: Health & Fitness
ISBN: 1400033462

This groundbreaking book by award-winning science writer and bestselling author of Why We Get Fat and The Case for Keto shows us that almost everything we believe about the nature of a healthy diet is wrong. For decades we have been taught that fat is bad for us, carbohydrates better, and that the key to a healthy weight is eating less and exercising more. Yet despite this advice, we have seen unprecedented epidemics of obesity and diabetes. Taubes argues that the problem lies in refined carbohydrates, like white flour, easily digested starches, and sugars, and that the key to good health is the kind of calories we take in, not the number. Called “a very important book,” by Andrew Weil and ”destined to change the way we think about food,” by Michael Pollan, this groundbreaking book by award-winning science writer Gary Taubes shows us that almost everything we believe about the nature of a healthy diet is wrong.