This compendium, written by active researchers in the field, encompasses topics ranging from anatomical and physiological subjects, through analyses of stimulus characteristics, prediction of sickness, and consideration of human factors, to pharmacological and behavioral therapeutic measures for terrestrial as well as microgravity travelers. Material often found scattered in diverse journals, paper-bound proceedings of symposia, difficult-to-find laboratory reports, or included with other topics in collections having a diffuse focus, are presented here in one volume dedicated to a single theme. The critical up-to-date- reviews are a first source for researchers and research program managers as well as an essential information source for engineers and practitioners.