Repurposing 13 Cis Retinoic Acid
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Author | : Ranbir Chander Sobti |
Publisher | : Springer Nature |
Total Pages | : 664 |
Release | : 2023-02-07 |
Genre | : Medical |
ISBN | : 9811953996 |
This book presents drug repurposing strategies to combat infectious diseases and cancer. It discusses key experimental and in silico approaches for modern drug repositioning, including signature matching, molecular docking, genome-wide associated studies, and network-based approaches aided by artificial intelligence. Further, the book presents various computational and experimental strategies for better understanding disease mechanisms and identify repurposed drug candidates for personalized pharmacotherapy. It also explores the databases for drug repositioning, summarizes the approaches taken for drug repositioning, and highlights and compares their characteristics and challenges. Towards the end, the book discusses challenges and limitations encountered in computational drug repositioning.
Author | : Naveen Chella |
Publisher | : Springer Nature |
Total Pages | : 253 |
Release | : |
Genre | : |
ISBN | : 9819750164 |
Author | : Amanda Tivnan |
Publisher | : Springer |
Total Pages | : 267 |
Release | : 2016-11-26 |
Genre | : Medical |
ISBN | : 3319465058 |
This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.
Author | : Kenneth K.W. To |
Publisher | : Academic Press |
Total Pages | : 460 |
Release | : 2020-07-29 |
Genre | : Science |
ISBN | : 0128199032 |
Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. - Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research - Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences - Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types
Author | : Carla Vitorino |
Publisher | : Elsevier |
Total Pages | : 788 |
Release | : 2023-05-17 |
Genre | : Science |
ISBN | : 0323999425 |
New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics provides a compendium of recent diagnostic and therapeutic advances in GBM, encompassing a pipeline of compounds and (bio) nanotechnology strategies that have stood out with potential increased antitumoral activity and capability to cross the blood-brain barrier. Issues and challenges related to their translation into the clinical practice and their contribution to the increase in survival rates and well-being of patients are addressed. This is a valuable resource for graduate students, oncologists, cancer researchers and members of the biomedical field who need to learn more on recent developments on the management of glioblastoma. The book is split in three parts: Diagnosis, focusing on biomarkers and techniques such PET/MRI, infrared thermography, and deep neural networks; Therapeutics, discussing new chemical entities, as natural products and repurposed drugs, and new formulation approaches, as nanotechnology-based and microRNA approaches; and Theranostics, explaining the role of omics, system-based approaches, and glioblastoma microenvironment. - Provides guidance towards recent advances of new chemical entities and delivery strategies targeted to glioblastoma - Includes overviews to help readers apply information in their research - Encompasses summarizing diagrams and real-world examples to facilitate comprehension and enhance the applicability of the content
Author | : |
Publisher | : |
Total Pages | : 764 |
Release | : 1980 |
Genre | : Toxicology |
ISBN | : |
Author | : Michael B. Sporn |
Publisher | : Academic Press |
Total Pages | : 441 |
Release | : 2012-12-02 |
Genre | : Science |
ISBN | : 0323141617 |
The Retinoids, Volume 1 covers the chemistry and biology of retinoids, with an emphasis on the role of retinoids in nutrition and in vision. After briefly discussing the discovery and nomenclature of retinoids, this six-chapter volume describes the chemical and physical properties of natural and synthetic retinoids, as well as the retinoidal benzoic acid derivatives. The book goes on describing various reactions with radioisotopes for the synthesis of retinoids and related compounds. Considerable chapters explain the chemical, physical, and biological methodologies for separating and measuring retinoids. A discussion on the relationships between structure and activity of retinoids is included. The last chapter addresses the role of vitamin A in animal and human nutrition. This volume also discusses the metabolism of vitamin A in normal and disease states, as well as its interaction with hormones, micronutrients, drugs, and alcohol. This volume is an ideal source for nutritionists, clinicians, and researchers who are interested in the progressing field of retinoid research.
Author | : National Library of Medicine (U.S.) |
Publisher | : |
Total Pages | : 552 |
Release | : 1994 |
Genre | : Medicine |
ISBN | : |
Author | : Sergey Kasparov |
Publisher | : MDPI |
Total Pages | : 422 |
Release | : 2019-06-17 |
Genre | : Medical |
ISBN | : 3038979902 |
Neuroglia is now published as part of Brain Sciences with a new section Editor-in-Chief Prof. Sergey Kasparov.
Author | : Carmen Salavastru |
Publisher | : Springer Nature |
Total Pages | : 494 |
Release | : 2021-03-10 |
Genre | : Medical |
ISBN | : 3030547795 |
This book describes the relationship of the skin with cardiovascular disease. It details the variety of genetic, autoimmune, metabolic and endocrine factors that link the two disciplines. Recognition of one sign or symptom in dermatology can lead to the investigation and discovery of an important related cardiac condition, the recognition of which is important to prevent cardiovascular complications. Similarly, a cardiac condition may be related to an underlying skin condition that requires treatment. Genetic examples of such instances included within the book include: pseudoxanthoma elasticum, epidermolysis bullosa with desmosome defects and plectin defects; Marfan syndrome; Autoimmune conditions include vasculitis, sarcoidosis, lupus; metabolic conditions include insulin resistance, eruptive xanthomas with hypertriglyceridemias and elevated cholesterol; endocrine disorders include thyroid acropachy with atrial fibrillation; insulin resistance with coronary artery disease and psoriasis or hidradenitis suppurativa. Skin and the Heart reviews the effects of genetic, autoimmune and endocrine diseases with connections between skin and heart. It is therefore a key reference for all practitioners and researchers working in both disciplines.