Reproductively Active Chemicals
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| Author | : Richard J. Lewis, Sr. |
| Publisher | : John Wiley & Sons |
| Total Pages | : 864 |
| Release | : 1991-09-03 |
| Genre | : Medical |
| ISBN | : 9780471289739 |
Reproductively Active Chemicals A Reference Guide Richard J. Lewis, Sr. Adverse effects on the human reproductive system due to chemical exposure are a growing concern of occupational safety and health professionals. While the effects of certain chemicals can be difficult to detect, and often go unnoticed or are mistakenly attributed to other causes, they can drastically increase risks of infertility, sterility, birth defects, and post-birth complications. Written by one of the foremost authorities in the field today, Reproductively Active Chemicals is the first book to identify, compile, and fully document the effects of more than 3,300 chemical substances known or suspected to cause adverse effects on human reproductive health. This major reference work features: Cross-indexes by synonym and identification number Vital information drawn from authoritative sources on hazardous chemicals, including chemical properties, toxicity, and synonyms Toxic effects indicating reported dominant reproductive effects The list of reproductively active materials covered here includes drugs, food additives, preservatives, ores, pesticides, dyes, and many other classes of materials. Some of the information also refers to materials of undefined composition. For each entry, the author provides the "DPIM" number, entry name, CAS number, molecular formula, molecular weight, a description of the material, and physical properties. He specifies effects on the male and female reproductive systems, mating success, fetal effects including abortion and transplacental carcinogenesis, and post-birth effects. Each reproductive or teratogenic effect reported includes the dose and species exposed, a brief characterization of the exposure conditions, and a reference to the source of the data. Human effects are presented separately from animal data to highlight the data's importance. With its broad range of crucial, up-to-date information, Reproductively Active Chemicals is an essential sourcebook for professionals in industrial health and safety and related areas. It offers vital information for protecting current and future generations from the dangers of chemical exposure, and will be especially helpful to industrial hygienists and toxicologists, safety and risk managers, loss prevention personnel, and industrial insurers.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 453 |
| Release | : 2000-02-03 |
| Genre | : Science |
| ISBN | : 0309064198 |
Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.
| Author | : National Academies of Sciences, Engineering, and Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 423 |
| Release | : 2017-08-14 |
| Genre | : Science |
| ISBN | : 0309458625 |
To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 476 |
| Release | : 1986-02-01 |
| Genre | : Nature |
| ISBN | : 0309036879 |
The most recent volume in the Drinking Water and Health series contains the results of a two-part study on the toxicity of drinking water contaminants. The first part examines current practices in risk assessment, identifies new noncancerous toxic responses to chemicals found in drinking water, and discusses the use of pharmacokinetic data to estimate the delivered dose and response. The second part of the book provides risk assessments for 14 specific compounds, 9 presented here for the first time.
| Author | : Ramesh C Gupta |
| Publisher | : Academic Press |
| Total Pages | : 1243 |
| Release | : 2011-04-04 |
| Genre | : Medical |
| ISBN | : 0123820332 |
Reproductive toxicology is a complex subject dealing with three components—parent, placenta, and fetus—and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife. - Provides a complete, integrated source of information on the key risk stages during reproduction and development - Includes coverage of emerging science such as stem cell application, toxicoproteomics, metabolomics, phthalates, infertility, teratogenicity, endocrine disruption, surveillance and regulatory considerations, and risk assessment - Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis
| Author | : Richard J. Lewis (Sr.) |
| Publisher | : Van Nostrand Reinhold Company |
| Total Pages | : 841 |
| Release | : 1991 |
| Genre | : Agents tératogènes - Guides, manuels, etc |
| ISBN | : 9780442318789 |
Identifies, compiles and fully documents the effects of some 3,300 chemical substances known or suspected to cause adverse effects on human reproductive health. For each entry, provides the "DPIM" number, entry name, CAS number, molecular formula, molecular weight, a description of the material, and physical properties. Each reproductive or teratogenic effect reported includes the dose and species exposed, a brief characterization of the exposure conditions, and a reference to the source of the data. Human effects are presented separately from animal data. Annotation copyrighted by Book News, Inc., Portland, OR
| Author | : Shanna H. Swan |
| Publisher | : Scribner |
| Total Pages | : 304 |
| Release | : 2021-02-23 |
| Genre | : Health & Fitness |
| ISBN | : 1982113669 |
In the tradition of Silent Spring and The Sixth Extinction, an urgent, meticulously researched, and groundbreaking book about the ways in which chemicals in the modern environment are changing—and endangering—human sexuality and fertility on the grandest scale, from renowned epidemiologist Shanna Swan. In 2017, author Shanna Swan and her team of researchers completed a major study. They found that over the past four decades, sperm levels among men in Western countries have dropped by more than 50 percent. They came to this conclusion after examining 185 studies involving close to 45,000 healthy men. The result sent shockwaves around the globe—but the story didn’t end there. It turns out our sexual development is changing in broader ways, for both men and women and even other species, and that the modern world is on pace to become an infertile one. How and why could this happen? What is hijacking our fertility and our health? Count Down unpacks these questions, revealing what Swan and other researchers have learned about how both lifestyle and chemical exposures are affecting our fertility, sexual development—potentially including the increase in gender fluidity—and general health as a species. Engagingly explaining the science and repercussions of these worldwide threats and providing simple and practical guidelines for effectively avoiding chemical goods (from water bottles to shaving cream) both as individuals and societies, Count Down is at once an urgent wake-up call, an illuminating read, and a vital tool for the protection of our future.
| Author | : United States. Public Health Service. Office of the Surgeon General |
| Publisher | : |
| Total Pages | : 728 |
| Release | : 2010 |
| Genre | : Government publications |
| ISBN | : |
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
| Author | : |
| Publisher | : |
| Total Pages | : 736 |
| Release | : 2006 |
| Genre | : Passive smoking |
| ISBN | : |
This Surgeon General's report returns to the topic of the health effects of involuntary exposure to tobacco smoke. The last comprehensive review of this evidence by the Department of Health and Human Services (DHHS) was in the 1986 Surgeon General's report, The Health Consequences of Involuntary Smoking, published 20 years ago this year. This new report updates the evidence of the harmful effects of involuntary exposure to tobacco smoke. This large body of research findings is captured in an accompanying dynamic database that profiles key epidemiologic findings, and allows the evidence on health effects of exposure to tobacco smoke to be synthesized and updated (following the format of the 2004 report, The Health Consequences of Smoking). The database enables users to explore the data and studies supporting the conclusions in the report. The database is available on the Web site of the Centers for Disease Control and Prevention (CDC) at http://www.cdc.gov/tobacco.
| Author | : Institute of Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 107 |
| Release | : 1995-07-17 |
| Genre | : Medical |
| ISBN | : 0309176115 |
Over the past several decades, public concern over exposure to ionizing radiation has increased. This concern has manifested itself in different ways depending on the perception of risk to different individuals and different groups and the circumstances of their exposure. One such group are those U.S. servicemen (the "Atomic Veterans" who participated in the atmospheric testing of nuclear weapons at the Nevada Test Site or in the Pacific Proving Grounds, who served with occupation forces in or near Hiroshima and Nagasaki, or who were prisoners of war in or near those cities at the time of, or shortly after, the atomic bombings. This book addresses the feasibility of conducting an epidemiologic study to determine if there is an increased risk of adverse reproductive outcomes in the spouses, children, and grandchildren of the Atomic Veterans.
