Repair And Adaptation Of Aged Skeletal Muscle To Nonpathological Muscle Damage
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| Author | : Jacob R. Sorensen |
| Publisher | : |
| Total Pages | : 85 |
| Release | : 2018 |
| Genre | : |
| ISBN | : |
The age-related loss of skeletal muscle mass and function is accompanied by a decline in regenerative capacity. The processes that facilitate healthy muscle repair are complex, involving several phases of degradation and rebuilding of muscle tissue and the surrounding microenvironment. Specifically, myogenic progenitor cells known as satellite cells are the most influential in repairing damaged muscle tissue. Following injury, satellite cells become activated and migrate, proliferate and fuse with mature skeletal muscle fibers to restore homeostasis to the tissue. However, satellite cells do not act in isolation, a robust inflammatory response is necessary to facilitate successful and rapid healing. Macrophages are one of the first and most abundant immune cells to infiltrate damaged skeletal muscle tissue. Primarily, macrophages adapt to a proinflammatory state to clear the area of cellular debris, promote degradation of the extracellular matrix and stimulate satellite cell activation and proliferation. Afterwards, a timely transition to an anti-inflammatory state directs rebuilding of the extracellular matrix and terminal differentiation of satellite cells. Indeed, the inhibition of macrophage activity leads to impaired healing and loss of skeletal muscle function. Little is known regarding the behavior of macrophages in aged skeletal muscle following injury in humans. Thus, the objective of this dissertation is to investigate the age-related response of macrophages in human skeletal muscle, and their role in the muscle repair.
| Author | : Peter M. Tiidus |
| Publisher | : Human Kinetics |
| Total Pages | : 360 |
| Release | : 2008 |
| Genre | : Muscles |
| ISBN | : 9780736058674 |
Attempts to cover a wide range of both basic research and applied clinical topics related to skeletal muscle damage and repair mechanisms and their application. This book examines muscle damage and repair mechanisms and issues in specific populations including older adults and special populations.
| Author | : National Academies of Sciences, Engineering, and Medicine |
| Publisher | : National Academies Press |
| Total Pages | : 483 |
| Release | : 2017-09-28 |
| Genre | : Medical |
| ISBN | : 0309459575 |
Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
| Author | : Dominique Dardevet |
| Publisher | : Academic Press |
| Total Pages | : 369 |
| Release | : 2016-06-08 |
| Genre | : Technology & Engineering |
| ISBN | : 0128023759 |
The Molecular Nutrition of Amino Acids and Proteins provides an in-depth look at the involvement and role of amino acids and proteins in molecular nutrition. Editor Dominique Dardevet has assembled a collection of chapters written by leading researchers and top professors that provide the reader with a comprehensive understanding of amino acids and proteins. The book provides an introduction to the fundamentals of amino acids and proteins as well as the composition of food. It then delves into the molecular biology of the cell and genetic machinery and its function. The Molecular Nutrition of Amino Acids and Proteins also features reference guides for terms and bullet-point summaries, making it readily accessible to novices while still providing the most up-to-date and detailed information that experienced researchers need. Provides a gentle introduction to the subject by first addressing nutritional information and then building in molecular aspects, clearly establishing fundamental information for the reader Facilitates reader comprehension by including succinct summary points in each chapter Contains a glossary of definitions that allows readers to easily reference terms Provides both a deep and broad understanding of the subject by containing overviews as well as detail-focused chapters
| Author | : Leslie Neal-Boylan |
| Publisher | : John Wiley & Sons |
| Total Pages | : 432 |
| Release | : 2011-11-28 |
| Genre | : Medical |
| ISBN | : 1118277856 |
Clinical Case Studies for the Family Nurse Practitioner is a key resource for advanced practice nurses and graduate students seeking to test their skills in assessing, diagnosing, and managing cases in family and primary care. Composed of more than 70 cases ranging from common to unique, the book compiles years of experience from experts in the field. It is organized chronologically, presenting cases from neonatal to geriatric care in a standard approach built on the SOAP format. This includes differential diagnosis and a series of critical thinking questions ideal for self-assessment or classroom use.
| Author | : Stirling Carpenter |
| Publisher | : New York : Churchill Livingstone |
| Total Pages | : 812 |
| Release | : 1984 |
| Genre | : Medical |
| ISBN | : |
This book has been described as the bible of muscle disease, from both a scientific and a clinical point of view. It is a comprehensive work that explains and illustrates in detail all pathological reactions of skeletal muscles that occur in human disease. The microscopic changes are illustrated by histochemistry, immunocytochemistry, resin histology, and electron microscopy. The pathological findings are correlated with the clinical picture whenever possible. The interpretation of the findings is scientifically based. To facilitate this process, the fundamentals of normal histology and biology of the muscle cell are also covered.The book has been thoroughly revised and expanded for this Second Edition to provide up-to-date coverage of the relevant molecular biology and molecular genetics, as well as extensive references. It has been well organized and richly illustrated by the authors, who have been at the forefront of muscle pathology and neuromuscular research for 35 years. This practical reference work is intended for neuropathologists, neurologists, and general pathologists who look at muscle biopsies. It will also serve as an introduction to muscle disease for neurology and pathology residents.
| Author | : Antonio Capurso |
| Publisher | : Springer |
| Total Pages | : 445 |
| Release | : 2018-07-23 |
| Genre | : Medical |
| ISBN | : 3319780840 |
This book illustrates the role of Mediterranean diet in connection with well-being and particularly its impact on health and elderly care, as well as on the mechanisms of aging. Aging is a natural process of human life. The knowledge that a healthy dietary regimen like the Mediterranean diet can effectively prevent or delay many diseases typically affecting aging people may help to better manage the aging process. From this point of view, knowledge of the numerous benefits of the Mediterranean-style diet may effectively promote better management of the burden of elderly care. As early as the 1950s, Ancel Keys pointed out the effectiveness of the Mediterranean diet in helping to control, and possibly avoid, myocardial infarction and/or cholesterol metabolism. Quite soon after the first studies were published, it became clear that the Mediterranean diet was beneficial not only in connection with cardiovascular disease but also many other diseases, from diabetes to hypertension, from cancer and thrombosis to neurodegenerative diseases, including dementia. Examining those benefits in detail, this book offers a valuable educational tool for young professionals and caregivers, as well as for students and trainees in Geriatrics and Nutrition.
| Author | : Carolyn Kisner |
| Publisher | : F.A. Davis |
| Total Pages | : 3368 |
| Release | : 2022-10-17 |
| Genre | : Medical |
| ISBN | : 1719649472 |
The premier text for therapeutic exercise Here is all the guidance you need to customize interventions for individuals with movement dysfunction. You’ll find the perfect balance of theory and clinical technique—in-depth discussions of the principles of therapeutic exercise and manual therapy and the most up-to-date exercise and management guidelines.
| Author | : John A. Vaughn |
| Publisher | : Springer Nature |
| Total Pages | : 336 |
| Release | : 2020-12-04 |
| Genre | : Medical |
| ISBN | : 303056309X |
This unique and comprehensive title offers state-of-the-art guidance on all of the clinical principles and practices needed in providing optimal health and well-being services for college students. Designed for college health professionals and administrators, this highly practical title is comprised of 24 chapters organized in three sections: Common Clinical Problems in College Health, Organizational and Administrative Considerations for College Health, and Population and Public Health Management on a College Campus. Section I topics include travel health services, tuberculosis, eating disorders in college health, and attention deficit hyperactivity disorder among college students, along with several other chapters. Subsequent chapters in Section II then delve into topics such as supporting the health and well-being of a diverse student population, student veterans, health science students, student safety in the clinical setting, and campus management of infectious disease outbreaks, among other topics. The book concludes with organizational considerations such as unique issues in the practice of medicine in the institutional context, situating healthcare within the broader context of wellness on campus, organizational structures of student health, funding student health services, and delivery of innovative healthcare services in college health. Developed by a renowned, multidisciplinary authorship of leaders in college health theory and practice, and coinciding with the founding of the American College Health Association 100 years ago, Principles and Practice of College Health will be of great interest to college health and well-being professionals as well as college administrators.
| Author | : Lawrence I. Gilbert |
| Publisher | : Academic Press |
| Total Pages | : 575 |
| Release | : 2011-08-16 |
| Genre | : Science |
| ISBN | : 0123847486 |
The publication of the extensive seven-volume work Comprehensive Molecular Insect Science provided a complete reference encompassing important developments and achievements in modern insect science. One of the most swiftly moving areas in entomological and comparative research is molecular biology, and this volume, Insect Molecular Biology and Biochemistry, is designed for those who desire a comprehensive yet concise work on important aspects of this topic. This volume contains ten fully revised or rewritten chapters from the original series as well as five completely new chapters on topics such as insect immunology, insect genomics, RNAi, and molecular biology of circadian rhythms and circadian behavior. The topics included are key to an understanding of insect development, with emphasis on the cuticle, digestive properties, and the transport of lipids; extensive and integrated chapters on cytochrome P450s; and the role of transposable elements in the developmental processes as well as programmed cell death. This volume will be of great value to senior investigators, graduate students, post-doctoral fellows and advanced undergraduate research students. It can also be used as a reference for graduate courses and seminars on the topic. Chapters will also be valuable to the applied biologist or entomologist, providing the requisite understanding necessary for probing the more applied research areas related to insect control. - Topics specially selected by the editor-in-chief of the original major reference work - Fully revised and new contributions bring together the latest research in the rapidly moving fields of insect molecular biology and insect biochemistry, including coverage of development, physiology, immunity and proteomics - Full-color provides readers with clear, useful illustrations to highlight important research findings
