Renal Fibrosis Mechanisms And Therapies
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| Author | : Bi-Cheng Liu |
| Publisher | : Springer |
| Total Pages | : 709 |
| Release | : 2019-08-09 |
| Genre | : Science |
| ISBN | : 9811388717 |
This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.
| Author | : Hui Y. Lan |
| Publisher | : Frontiers Media SA |
| Total Pages | : 84 |
| Release | : 2018-07-26 |
| Genre | : |
| ISBN | : 2889454991 |
Scarring of the glomerular and tubulointerstitial compartments is a hallmark of progressive kidney disease. Renal fibrosis involves a complex interplay between kidney cells, leukocytes and fibroblasts in which transforming growth factor-β (TGF-β) plays a key role. This eBook provides a comprehensive update on TGF-β signalling pathways and introduces a range of cellular and molecular mechanisms involved in renal fibrosis both upstream and downstream of TGF-β. The wide variety of potential new targets described herein bodes well for the future development of effective therapies to tackle the major clinical problem of progressive renal fibrosis.
| Author | : Mohammed S. Razzaque |
| Publisher | : Karger Medical and Scientific Publishers |
| Total Pages | : 222 |
| Release | : 2003-01-01 |
| Genre | : Medical |
| ISBN | : 3805575688 |
This publication provides a synopsis of the rapid progress made in the field of renal cell biology during the last decade, progress which has resulted in a better conceptual understanding of the cellular and molecular mechanisms of fibrotic renal disease. These developments have provided new therapeutic choices and led to the discovery of gene-based therapeutic options. The topics covered in this book have been carefully selected from the immense number of aspects of the disease to provide essential information on the molecular basis of renal fibrosis. Individual chapters discuss topics such as proteinuria and tubulointerstitial injury, the roles and regulation of TGF-beta, chemokines, oxidant stress, matrix remodeling, significance of renal expression of NF-kappa, and the potential impact of cell death in renal fibrosis.Written so as to present the complex information as simply as possible, this publication will be a very useful tool for general health professionals involved in the fields of immunology and cell biology, as well as for clinicians and researchers within the fields of nephrology, pathology and matrix biology.
| Author | : Xin J. Zhou |
| Publisher | : Cambridge University Press |
| Total Pages | : 691 |
| Release | : 2017-03-02 |
| Genre | : Medical |
| ISBN | : 1316613984 |
An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.
| Author | : Patrick C. Baer |
| Publisher | : MDPI |
| Total Pages | : 496 |
| Release | : 2020-04-03 |
| Genre | : Medical |
| ISBN | : 3039285386 |
Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets.
| Author | : Elisabeth Godefrida Dieuwke Stribos |
| Publisher | : |
| Total Pages | : 191 |
| Release | : 2017 |
| Genre | : |
| ISBN | : 9789403402413 |
| Author | : Hikaru Koide |
| Publisher | : |
| Total Pages | : 244 |
| Release | : 1994 |
| Genre | : Medical |
| ISBN | : |
| Author | : |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2018 |
| Genre | : |
| ISBN | : |
| Author | : G.B. Silva Junior |
| Publisher | : Karger Medical and Scientific Publishers |
| Total Pages | : 369 |
| Release | : 2021-11-02 |
| Genre | : Medical |
| ISBN | : 331806937X |
Nephrology is one of the fastest growing specialties in medicine. Nevertheless, kidney disease is one of the most serious unmet health needs in many countries. To provide healthcare access with the desirable equity worldwide, the nephrology community needs to discuss this public health issue and take part in decisions for elaboration of public health policies with more justice and equity. This book brings together key current public health problems that affect kidney function and illuminates them in contributions by an international group of nephrologists and general practitioners. The chapters review current knowledge and provide guidelines to manage these conditions and decrease the disease burden. At the end, developments in the digital era and their application to kidney disease treatment are synthesized, and a broader outlook on the future of nephrology is given. Ultimately, the publication aims to gather nephrology and public health expertise from researchers from all over the world, providing a broad vision of issues that must be discussed and overcome to guarantee a better treatment for patients with kidney diseases in the world today.
| Author | : Haruki Yamada |
| Publisher | : CRC Press |
| Total Pages | : 250 |
| Release | : 2005-04-29 |
| Genre | : Health & Fitness |
| ISBN | : 9781420023510 |
Kampo is a traditional Japanese herbal medicine that takes a holistic approach to healing. Since Kampo is currently being used for the treatment of a wide range of diseases with many reports of clinical effectiveness, it is playing an increasingly important role in Japan's modern-day health care. Juzen-taiho-to (Shi-Quan-Da-Bu-Tang): Scientific Evaluation and Clinical Applications presents a concise overview of the important Kampo formula of Juzen-taiho-to. The book describes the therapeutic indications and traditional uses of Juzen-taiho-to, followed by its taxonomy, cultivation, quality assurance, and chemical constituents and pharmacological actions of raw plant material as the component herbs. Experts in the field discuss up-to-date findings and topics associated with the pharmacology and clinical application of Juzen-taiho-to, including its important immunomodulating, anti-tumor, and anti-metastatic properties, toxicology and side effects, and other related formulations. Today, Kampo medicine is steadily gaining acceptance by Japan's national health insurance system, the medical community, and contemporary society. This book provides a comprehensive review of Juzen-taiho-to and demonstrates how Kampo and other herbal medicines are becoming the popular, practical, and preferred treatments of tomorrow.
