Register Of Research
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Author | : John I. Gallin |
Publisher | : Elsevier |
Total Pages | : 447 |
Release | : 2011-04-28 |
Genre | : Science |
ISBN | : 0080489567 |
The second edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers.*Incorporates new chapters on Managing Conflicts of Interest in Human Subjects Research, Clinical Research from the Patient's Perspective, The Clinical Researcher and the Media, Data Management in Clinical Research, Evaluation of a Protocol Budget, Clinical Research from the Industry Perspective, and Genetics in Clinical Research *Addresses the vast opportunities for translation of basic science observations to the bedside through clinical research*Delves into data management and addresses how to collect data and use it for discovery*Contains valuable, up-to-date information on how to obtain funding from the federal government
Author | : Agency for Healthcare Research and Quality/AHRQ |
Publisher | : Government Printing Office |
Total Pages | : 385 |
Release | : 2014-04-01 |
Genre | : Medical |
ISBN | : 1587634333 |
This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.
Author | : Douglas Biber |
Publisher | : Cambridge University Press |
Total Pages | : 355 |
Release | : 2009-10-29 |
Genre | : Language Arts & Disciplines |
ISBN | : 0521860601 |
This book describes the most important kinds of texts in English and introduces the methodological techniques used to analyse them. Three analytical approaches are introduced and compared, describing a wide range of texts from the perspectives of register, genre and style. The primary focus of the book is on the analysis of registers. Part 1 introduces an analytical framework for studying registers, genre conventions, and styles. Part 2 provides detailed descriptions of particular text varieties in English, including spoken interpersonal varieties (conversation, university office hours, service encounters), written varieties (newspapers, academic prose, fiction), and emerging electronic varieties (e-mail, internet forums, text messages). Finally, Part 3 introduces advanced analytical approaches using corpora, and discusses theoretical concerns, such as the place of register studies in linguistics, and practical applications of register analysis. Each chapter ends with three types of activities: reflection and review activities, analysis activities, and larger project ideas.
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 334 |
Release | : 2009-03-24 |
Genre | : Computers |
ISBN | : 0309124999 |
In the realm of health care, privacy protections are needed to preserve patients' dignity and prevent possible harms. Ten years ago, to address these concerns as well as set guidelines for ethical health research, Congress called for a set of federal standards now known as the HIPAA Privacy Rule. In its 2009 report, Beyond the HIPAA Privacy Rule: Enhancing Privacy, Improving Health Through Research, the Institute of Medicine's Committee on Health Research and the Privacy of Health Information concludes that the HIPAA Privacy Rule does not protect privacy as well as it should, and that it impedes important health research.
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 236 |
Release | : 2015-04-20 |
Genre | : Medical |
ISBN | : 0309316324 |
Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research-from funders, to researchers, to journals, to physicians, and ultimately, to patients.
Author | : Institute of Medicine |
Publisher | : National Academies Press |
Total Pages | : 267 |
Release | : 2011-07-20 |
Genre | : Medical |
ISBN | : 0309164257 |
Healthcare decision makers in search of reliable information that compares health interventions increasingly turn to systematic reviews for the best summary of the evidence. Systematic reviews identify, select, assess, and synthesize the findings of similar but separate studies, and can help clarify what is known and not known about the potential benefits and harms of drugs, devices, and other healthcare services. Systematic reviews can be helpful for clinicians who want to integrate research findings into their daily practices, for patients to make well-informed choices about their own care, for professional medical societies and other organizations that develop clinical practice guidelines. Too often systematic reviews are of uncertain or poor quality. There are no universally accepted standards for developing systematic reviews leading to variability in how conflicts of interest and biases are handled, how evidence is appraised, and the overall scientific rigor of the process. In Finding What Works in Health Care the Institute of Medicine (IOM) recommends 21 standards for developing high-quality systematic reviews of comparative effectiveness research. The standards address the entire systematic review process from the initial steps of formulating the topic and building the review team to producing a detailed final report that synthesizes what the evidence shows and where knowledge gaps remain. Finding What Works in Health Care also proposes a framework for improving the quality of the science underpinning systematic reviews. This book will serve as a vital resource for both sponsors and producers of systematic reviews of comparative effectiveness research.
Author | : Ezekiel J. Emanuel |
Publisher | : |
Total Pages | : 532 |
Release | : 2003 |
Genre | : Medical |
ISBN | : |
Professionals in need of such training and bioethicists will be interested.
Author | : John Moschella CFA CPA |
Publisher | : |
Total Pages | : 239 |
Release | : 2019-09-08 |
Genre | : |
ISBN | : 9781689598323 |
From the Author: This is not another boring, impossible to read, thousand-page textbook. On the contrary, this is an exciting journey into the world of Wall Street-style financial modeling. The motivation behind this book comes from my days as a new research analyst, trying to juggle the demands of 80-plus hour work weeks, FINRA exams, and client meetings, while attempting to learn the basics of modeling. At the time I sought outside educational resources only to find useless classes focused on spreadsheet tricks, or high-level theory-based books with little practical value. What I really needed was someone to sit down, and show me exactly how to build a model, using a real company as an example, from start to finish. Now, years after leaving the sell-side rat race, I have written the book that I sought when I was new to the street. The result is a clear, concise, easy to read guide on how to build a three-statement model. The book starts with an introduction to the industry and important background information for new analysts. Then, beginning with a blank spreadsheet, the text demonstrates exactly how to build a model using an actual company example. Throughout the chapters there are numerous images of the model which highlight key elements, as if I were pointing to a computer screen and explaining it directly to the reader. There are also more than 30 spreadsheets available for download to follow along with the text. After the model is built, I discuss effective ways to use it for forecasting and share valuation, and demonstrate how to maintain the model over time. I have also included insight from my experience in research, pitfalls to watch for, and frequently asked questions from my research team, to help add color to the subject matter. This book is a self-published, grassroots effort. You will not find a shiny professional cover or expert photographs inside. This book is less what you would expect from a traditional textbook, and closer to an informal conversation between me and the reader. Sometimes all you need is to talk to someone who has been there, and that is what you will get between these two covers. Ultimately the goal is to have my readers come away from their experience feeling empowered and excited to build an earnings model of their own. Regardless of whether or not you intend to start a career in equity research, if you would like to learn how to model earnings for a company, then this book is a good place to get started.
Author | : United States. National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research |
Publisher | : |
Total Pages | : 614 |
Release | : 1978 |
Genre | : Ethics, Medical |
ISBN | : |
Author | : Douglas Biber |
Publisher | : Oxford University Press |
Total Pages | : 398 |
Release | : 1994-01-13 |
Genre | : Language Arts & Disciplines |
ISBN | : 0195359321 |
This collection brings together several perspectives on language varieties defined according to their contexts of use--what are variously called registers, sublanguages, or genres. The volume highlights the importance of these central linguistic phenomena; it includes empirical analyses and linguistic descriptions, as well as explanations for existing patterns of variation and proposals for theoretical frameworks. The book treats languages in obsolescence and in their youth; it examines registers from languages from around the globe; and it offers several of the most complete studies of registers and register variation published to date, adopting both synchronic and diachronic perspectives.