Inasmuch as “sex” and “sexuality” are not words often spoken from pulpits and in academic theological circles, a vast number of utterances have been made in the name of so-called “Christian values” and “biblical views” on sex and sexuality. These are often given from moral-ethical perspectives, and seemingly very prescriptive: who should have sex with whom, when sex should take place, which purposes sex should serve—and especially, when sex is wrong. Moreover, often there is little or no recognition of the complexities surrounding human sexuality, resulting in what appears to be a blueprint for sexuality, applicable to all persons. This volume contains fourteen theological and ethical reflections by South African scholars on human sexuality, with the aim of exploring what a sexual reformation within Christian dialogue might entail. Presented in three sections—namely, systematic theological reflections, biblical reflections, and ethical reflections—the essays represent a range of topics from a variety of perspectives: Luther and marriage; sexual abuse in the Catholic Church; body theology and the sexual revolution; reproductive technologies, sexuality and reproduction; reproductive loss; hermeneutical choices and gender reformation in (South) Africa; queer engagements with “bra” Joseph; explorations on Paul and sex; rape culture and violent deities; the church’s moral authority and sexual ethics; practical-theological considerations regarding infertility; empirical research on masculinities in Zambia; and the lived experience of transgender people in African Independent Churches.