Recombinant DNA Technologies in Neuroendocrinology

Recombinant DNA Technologies in Neuroendocrinology
Author: Hiroo Imura
Publisher: Springer Science & Business Media
Total Pages: 222
Release: 2012-12-06
Genre: Medical
ISBN: 3642775039

This volume covers new aspects and future directions in molecular neuroendocrinology, an important and rapidly growing area in neuroendocrinology. Among the various neurotransmitters or neuromodulators that play an important role in the control of endocrine functions, neuropeptides and related proteins have drawn special attention because of their diversity and complexity in action. More recently, molecular biology has become an essential tool of research in this area. Various genes encoding neuropeptides and other related pro- teins have been cloned, and the regulation of expression of these genes has been studied extensively. Transgenic animals have been used in studying the function of the gene in que- stion. In-situ hybridization is being applied to localize the site of production and analyze the regulation of pro- duction of peptides or proteins.

Recombinant DNA Technology

Recombinant DNA Technology
Author: Siddra Ijaz
Publisher: Cambridge Scholars Publishing
Total Pages: 156
Release: 2019-08-13
Genre: Science
ISBN: 1527538443

Genetic engineering is a rapidly growing field in the area of biological sciences. The driving forces behind this are the challenges encountered by health sectors, agriculture, the environment, and industry. As such, accurate and comprehensive knowledge about the philosophy, principles and application of genetic engineering is indispensable for students and researchers to harness maximum opportunities from this field of science. This volume gathers together comprehensive information regarding genetic engineering from recent studies, and presents it in a coherent manner. As such, it will be of interest to undergraduate and postgraduate students and researchers working in the biological sciences.

Recombinant DNA Technologies in Neuroendocrinology

Recombinant DNA Technologies in Neuroendocrinology
Author: Hiroo Imura
Publisher: Springer
Total Pages: 222
Release: 1992-12-08
Genre: Medical
ISBN: 9783540554554

1.1 Mechanism of Action of Glucocorticoid Hormones The current model of glucocorticoid hormone action is summarized in Fig. 1. After synthesis, glucocorticoids are secreted into the blood stream and trans­ ported to target cells where they bind with high affinity (K-1O-9M) and d specificity to the intracellular glucocorticoid receptor (GR) protein. The sub­ cellular localization of hormone-free GR is still a controversial issue. However, most data support the idea that unliganded GR is in the cytoplasmic compartment or loosely associated with the nucleus (Picard and Yamamoto 1987; Gustafsson et al. 1987 and references therein; LaFond et al. 1988; Gasc et al. 1989). Upon ligand binding, GR is activated into a form capable of interacting with DNA. The mechanism of GR activation probably involves a conformational change and dis­ sociation from nonreceptor components, e.g., the 90-kDA heat shock protein (hsp90: Pratt et al. 1988; Bresnick et al. 1989; Denis and Gustafsson 1989). The subcellular location of activated GR has been firmly established to be inside the nucleus. In vivo, the hormone-receptor complex interacts with specific DNA Activation r:::.. ~ qc [!3-GC ... &.GC~ j ~ ? , BIOLOGICAL EFFECTS " t , Active Protein , , ~Vl\lent.

Endocrine Genes

Endocrine Genes
Author: Yun-Fai Lau
Publisher: Oxford University Press, USA
Total Pages: 252
Release: 1988
Genre: Endocrine glands
ISBN:

The application of recombinant DNA techniques to endocrinology is an exciting area of biomedical research. These and other new methods have made it possible to clone many endocrine genes--such as those for insulin and growth hormone--to determine their nucleatide sequences, and to study their expression both in vitro and in vivo. Derived from a series of molecular endocrinology research seminars, this book covers the basics of gene cloning, structural analysis and the regulation of gene expression in selected endocrine systems. The first part focuses on analytical methods and experimental approaches, including DNA-mediated gene transfer, identification of tissue-specific transcription factors and regulatory sequences, in situ hybridization of mRNA, and gene mapping on human chromosomes. The second part presents molecular studies of various endocrine systems, each combining different approaches.

Molecular Biotechnology

Molecular Biotechnology
Author: Bernard R. Glick
Publisher:
Total Pages: 724
Release: 1998
Genre: Medical
ISBN:

The second edition explains the principles of recombinant DNA technology as well as other important techniques such as DNA sequencing, the polymerase chain reaction, and the production of monclonal antibodies.

Endocrinology - E-Book

Endocrinology - E-Book
Author: J. Larry Jameson
Publisher: Elsevier Health Sciences
Total Pages: 3076
Release: 2010-05-18
Genre: Medical
ISBN: 1455711268

ENDOCRINOLOGY, edited by J. Larry Jameson, MD, PhD and Leslie J. De Groot, MD, has been considered the definitive source in its field for decades. Now this landmark reference has been exhaustively updated to bring you the latest clinical guidance on all aspects of diagnosis and treatment for the full range of endocrine and metabolism disorders, including new information on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors. Entirely new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis keep you well informed on today’s hot topics. You’ll benefit from unique, global perspectives on adult and pediatric endocrinology prepared by an international team of renowned authorities. This reference is optimally designed to help you succeed in your demanding practice and ensure the best possible outcomes for every patient. Overcome virtually any clinical challenge with detailed, expert coverage of every area of endocrinology, authored by hundreds of leading luminaries in the field. Provide state-of-the-art care with comprehensive updates on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors ... brand-new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis ... expanded coverage of sports performance, including testosterone, androgen research, and bone growth and deterioration ... and the newest discoveries in genetics and how they affect patient care. Make the best clinical decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion. Rapidly consult with trusted authorities thanks to new expert-opinion treatment strategies and recommendations. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information more quickly, while still getting the complete coverage you expect.

Basic Introduction to Astrobiotechnology

Basic Introduction to Astrobiotechnology
Author: Dr. Arun Kumar Singh
Publisher: AL - LINA PUBLICATION
Total Pages: 308
Release:
Genre: Juvenile Fiction
ISBN: 9394702725

The book entitled “Basic Introduction to Astrobiotechnology” is according the requirement and need for the information and knowledge from different area of Astronomy and Biotechnology. Theoretical and observational physics provides a basis for analyzing and understanding bodies that are too far from us. It is difficult to visit physically or even measure directly. But this information’s of the universe may lead us to a better understanding of the origins of our universe, refining theories like the big bang or understanding dark energy. Astrobiotechnology is an emerging field at the intersection of biology, chemistry, physics, and space exploration. It seeks to understand the fundamental principles of life and apply this knowledge to investigate the possibilities of life elsewhere in the universe. By harnessing the power of biotechnology, we can explore and manipulate the building blocks of life, paving the way for breakthroughs in space exploration, colonization, and the search for extraterrestrial life. This book aims to provide a comprehensive overview of astrobiotechnology, covering a wide range of topics that will intrigue both scientists and enthusiasts alike. We will delve into the origins of life on Earth and the conditions necessary for life to thrive in extreme environments. We will explore the tools and techniques used in astrobiological research, such as genetic engineering, synthetic biology, and biomaterials. Additionally, we will study the potential for terraforming other planets and moons, and the ethical implications that arise from these endeavors. It is important to note that Astrobiotechnology is not just a theoretical concept; it has real-world applications and implications for our future as a species. By studying the adaptations of life in extreme environments, we gain valuable insights into the potential for sustainable life on Earth and the possibilities of adapting life to survive in the hostile environments of space. Furthermore, the exp

Current Concepts in Pediatric Endocrinology

Current Concepts in Pediatric Endocrinology
Author: Dennis M. Styne
Publisher: Elsevier Publishing Company
Total Pages: 232
Release: 1987
Genre: Medical
ISBN:

This volume, written by internationally acknowledged experts in their fields, covers new developments in pediatric endocrinology. The first two chapters highlight the relationship between advances in biochemical genetics and the diagnosis and therapy of pediatric endocrine disorders. The remaining chapters focus on recent research in such areas as: neuroendocrinology and pediatric endocrinology, circadian rhythms, somatomedins, diabetes mellitus, and the psychological effects of hypopituitarism.