Recent Advances In Organocatalysis
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| Author | : Iyad Karamé |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 194 |
| Release | : 2016-09-28 |
| Genre | : Science |
| ISBN | : 9535126725 |
Organocatalysis has recently attracted enormous attention as green and sustainable catalysis. It was realized as a fundamental field providing wide families of catalysts for important organic transformations. It will certainly develop in the future. Given the diversity of accessible transformations, metal-catalyzed reactions have become major tools in organic synthesis that will undoubtedly continue to have an important impact in the future. Alternatively, over the last years, a metal-free approach such as organocatalysis has reached a level of faithfulness, allowing researchers to discover new catalytic systems based on engagement of new or early-prepared organic molecules as organocatalysts. Organocatalysis meets green chemistry principles, especially the reduction of toxicity and chemical accidents, the biodegradability, and the use of benign and friendlier reaction media and conditions.
| Author | : Manfred Reetz |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 348 |
| Release | : 2008-05-27 |
| Genre | : Science |
| ISBN | : 3540734953 |
This book provides an excellent overview on state-of-the-art of modern organocatalysis. It presents the contributions from leading experts, with backgrounds in academia and industry, to an Ernst Schering Research Foundation Symposium held in April 2007. It will be of interest to those who want a general overview of the topic, but also to those who want to learn more about the state-of-the-art, current trends and perspectives in this highly dynamic field of research.
| Author | : Maurizio Benaglia |
| Publisher | : Walter de Gruyter GmbH & Co KG |
| Total Pages | : 451 |
| Release | : 2021-07-19 |
| Genre | : Science |
| ISBN | : 3110590050 |
Organocatalysis is considered today one of the three pillars in asymmetric catalysis, along with biocatalysis and organometallic catalysis. The possibility to combine organocatalysis with radical chemistry, photocatalysis and enabling technologies opened new avenues in organic synthesis.
| Author | : Bruce A. Arndtsen |
| Publisher | : Springer Nature |
| Total Pages | : 211 |
| Release | : 2020-04-24 |
| Genre | : Science |
| ISBN | : 3030438511 |
The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.The chapter "Enamine/Transition Metal Combined Catalysis: Catalytic Transformations Involving Organometallic Electrophilic Intermediates" is available open access under a CC BY 4.0 License via link.springer.com.
| Author | : Maxime R Vitale |
| Publisher | : Elsevier |
| Total Pages | : 186 |
| Release | : 2017-07-21 |
| Genre | : Technology & Engineering |
| ISBN | : 0081011555 |
Considering the challenge of sustainability facing our society in the coming decades, catalysis is without any doubt a research area of major importance. In this regard, asymmetric organocatalysis, now considered a pillar of green chemistry, deserves particular attention. The first chapter of this volume examines the topic of asymmetric organocatalysis in light of radical chemistry. Recent important progress in this field has been attained by promoting the formation and harnessing the high reactivity of open-shell intermediates. Merging organocatalysis with radical chemistry has been the key to solving some longstanding bottlenecks, and has also significantly contributed to reinforcing the key role of organocatalysis in asymmetric catalysis. This chapter presents the most significant developments in this area, with a particular focus on asymmetric SOMO- and photoredox-organocatalyzed transformations. Chapter 2 focuses on quaternary ammonium salts (R4N+X-), especially chiral derivatives, and their behavior as unique catalysts in organocatalysis. Forming chiral ion-pairs capable of promoting asymmetric reactions, they also operate as unique "transporters involved in phase transfer catalytic processes between liquid–liquid or liquid–solid systems. Furthermore, they offer unique opportunities when forming cooperative ion-paired entities R4N+X-, allowing a synergistic implication of the counter-ion X- either as Brønsted bases or Lewis bases. Specific design of such chiral catalysts in modern chemistry and better insight into their mode of activation facilitates efficient and unprecedented chemical transformations. This chapter provides an overview of the use of chiral quaternary ammonium salts in organocatalysis, emphasizing both general mechanistic aspects and the scope of this approach. - Presents the most significant developments with a particular focus on asymmetric SOMO- and photoredox-organocatalyzed transformations - Givies a larger overview of chiral ammonium salts in organocatalysis rather than a specific review dedicated to specialists in this area - Affords a historical evolution of this field of research
| Author | : Maurizio Fagnoni |
| Publisher | : World Scientific |
| Total Pages | : 600 |
| Release | : 2019-02-19 |
| Genre | : Science |
| ISBN | : 1786346060 |
The use of organocatalysts able to photocatalyze an organic reaction is a rapidly growing field. These photocatalyzed transformations are more environmentally sustainable with respect to the use of expensive/toxic metal-based (photo)catalysts.Based on the authors' extensive experience in photogenerated intermediates, this book presents an overview on photocatalyzed organic processes having a synthetic significance, where an organic molecule functions as the photocatalyst.After a brief introduction defining the nature and the characteristics of a photoorganocatalyst (POC), the chapters are organized according to the class of POC used, as detailed below.Each chapter begins with a summary of the photophysical characteristics of the POCs and is followed by selected examples of synthetic applications. The last two chapters are devoted to the adoption of photoorganocatalysis in polymerization and to flow photoorganocatalysis. These in-depth explanations and practical applications make this title an essential reading for any chemistry student interested in organic (sustainable) synthesis.
| Author | : Michelangelo Gruttadauria |
| Publisher | : John Wiley & Sons |
| Total Pages | : 721 |
| Release | : 2011-07-05 |
| Genre | : Science |
| ISBN | : 1118087984 |
This book covers advances in the methods of catalytic asymmetric synthesis and their applications. Coverage moves from new materials and technologies to homogeneous metal-free catalysts and homogeneous metal catalysts. The applications of several methodologies for the synthesis of biologically active molecules are discussed. Part I addresses recent advances in new materials and technologies such as supported catalysts, supports, self-supported catalysts, chiral ionic liquids, supercritical fluids, flow reactors and microwaves related to asymmetric catalysis. Part II covers advances and milestones in organocatalytic, enzymatic and metal-based mediated asymmetric synthesis, including applications for the synthesis of biologically active molecules. Written by leading international experts, this book consists of 16 chapters with 2000 References and illustrations of 560 schemes and figures.
| Author | : Peter I. Dalko |
| Publisher | : Wiley-VCH |
| Total Pages | : 0 |
| Release | : 2013-12-04 |
| Genre | : Science |
| ISBN | : 9783527332366 |
Structured in three parts this manual recollects efficient organocatalytic transformations around clear principles that meet actual standard in asymmetric synthesis. Chapters were written by acknowledged leaders of the organocatalysis field, and are presented in a concise way. Volume 1: Privileged Catalysts gives insight to readers to the continuously increasing variety of catalysts, and the relatively complex interactions that make organocatalytic reactions selective. An appendix recollects catalyst structures with the adequate cross-references. Volume 2: Activations covers the fundamental activation types (non-covalent and covalent activations) and helps understanding the importance of physical parameters, and in particular, the role of water, that influences reactivity and selectivity. Volume 3: Reactions and Applications highlights transformations by reaction types. The final part of this volume is dedicated to application in multistep synthesis and industrial applications. Considering the ever increasing interest in the organocatalysis field, the book aims addressing to a large audience: to academic, and, industrial researchers, students and teachers who are interested in synthetic organic chemistry at advanced level. This book provides non-specialists with an introduction to the topic as well as serving as a valuable source for newcomers and researchers searching for an up-to-date and comprehensive overview of this promising area of synthetic organic chemistry.
| Author | : Maurizio Benaglia |
| Publisher | : John Wiley & Sons |
| Total Pages | : 492 |
| Release | : 2020-04-06 |
| Genre | : Technology & Engineering |
| ISBN | : 3527345094 |
A comprehensive resource on techniques and applications for immobilizing catalysts Catalyst Immobilization: Methods and Applications covers catalyst immobilization topics including technologies, materials, characterization, chemical activity, and recyclability. The book also presents innovative applications for supported catalysts, such as flow chemistry and machine-assisted organic synthesis. Written by an international panel of expert contributors, this book outlines the general principles of catalyst immobilization and explores different types of supports employed in catalyst heterogenization. The book?s chapters examine the immobilization of chiral organocatalysts, reactions in flow reactors, 3D printed devices for catalytic systems, and more. Catalyst Immobilization offers a modern vision and a broad and critical view of this exciting field. This important book: -Offers a guide to supported and therefore recyclable catalysts, which is one of the most important tools for developing a highly sustainable chemistry -Presents various immobilization techniques and applications -Explores new trends, such as 3D printed devices for catalytic systems -Contains information from a leading international team of authors Written for catalytic chemists, organic chemists, process engineers, biochemists, surface chemists, materials scientists, analytical chemists, Catalyst Immobilization: Methods and Applications presents the latest developments and includes a review of the innovative trends such as flow chemistry, reactions in microreactors, and beyond.
| Author | : Jun Yang |
| Publisher | : OAE Publishing Inc. |
| Total Pages | : 54 |
| Release | : 2023-02-08 |
| Genre | : Science |
| ISBN | : |
Chiral spirolactones, including spiropropyllactones, spirobutyrolactones, and spirovalerolactones, are important heterocyclic frameworks that attracted the attention of organic and medicinal chemists because these motifs constitute the core structure of several natural products and bioactive molecules. The absolute configuration and the substituents on the fully substituted spirocyclic stereocenter of the lactone can potentially enhance specificity for ligand-protein binding and enhance bioavailability, potency, and metabolic stability. So, intensive attention from chemists has been paid to the synthetic methods leading to such prominent structural motifs. The synthetic methods can be divided into two main classes. The first approach takes advantage of the presence of the existing lactone structure and focuses on its functionalization. The second approach is the lactone framework constructed from various precursors in a direct spirolactonization reaction. In this review, for convenience in reading, the recent advances in the synthesis of spirolactones are summarized and discussed according to the two major organocatalytic asymmetric synthetic routes: (i) using the lactone-related frameworks as building blocks; and (ii) direct spirolactonization reaction using various reagents. This review also describes both the mechanisms and related transformations, and gives some insights into challenging issues in this research field, which will enlighten the future development of this field.
